Capsule structure changes associated with Cryptococcus neoformans crossing of the blood-brain barrier

American Journal of Pathology

Volumn 166, Issue 2, 2005, Pages 421-432

  Charlier, Caroline ^a   Chrétien, Fabrice ^b   Baudrimont, Marielle ^c   Mordelet, Elodie ^a   Lortholary, Olivier ^a,d   Dromer, Françoise ^a  

^a CNRS   (France)

^b HENRI MONDOR HOSPITAL   (France)

^c CENTRE HOSPITALIER SAINTE ANNE   (France)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD SAMPLING; BRAIN CAPILLARY; BRAIN CORTEX; CELL SIZE; CHOROID PLEXUS; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; ELECTRON MICROSCOPY; EXPERIMENTAL INFECTION; HISTOPATHOLOGY; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; MALE; MENINGOENCEPHALITIS; MENINX; MICROVASCULATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOCYST;

EID: 13244265941     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)62265-1     Document Type: Article

References (59)

1. Mitchell TG, Perfect JR: Cryptococcosis in the era of AIDS: 100 years after the discovery of Cryptococcus neoformans. Clin Microbiol Rev 1995, 8:515-548
2. Mirza SA, Phelan M, Rimland D, Graviss E, Hamill R, Brandt ME, Gardner T, Sattah M, Ponce De Leon G, Baughman W, Hajjeh RA: The changing epidemiology of cryptococcosis: an update from population-based active surveillance in two large metropolitan areas, 1992-2000. Clin Infect Dis 2003, 36:789-794
3. Lortholary O, Droz C, Sitbon K, Zeller V, Neuville S, Alvarez M, Boisbieux A, Botterel F, Dellamonica P, Dromer F, Chêne G, the French Cryptococcosis Study Group: Long-term outcome of HIV-associated cryptococcosis (CC) at the time of HAART: results of the Multicenter Cohort "Cryptostop". Presented at the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, 2003
4. Dromer F, Mathoulin-Pelissier S, Fontanet A, Ronin O, Dupont B, Lortholary O, on behalf of the French Cryptococcosis Study Group: Epidemiology of HIV-associated cryptococcosis in France (1985-2001): comparison of the pre- and post-HAART eras. Aids 2004, 18:555-562
5. Dromer F, Ronin O, Dupont B: Isolation of Cryptococcus neoformans var. gattii from an Asian patient in France: evidence for dormant infection in healthy subjects. J Med Vet Mycol 1992, 30:395-397
6. Goldman DL, Khine H, Abadi J, Lindenberg DJ, Pirofski L-A, Niang R, Casadevall A: Serologic evidence for Cryptococcus neoformans infection in early childhood. Pediatrics 2001, 107:E66
7. Garcia-Hermoso D, Janbon G, Dromer F: Epidemiological evidence for dormant Cryptococcus neoformans infection. J Clin Microbiol 1999, 37:3204-3209
8. Diamond RD, Bennett JE: Prognostic factors in cryptococcal meningitis: a study in 111 cases. Ann Intern Med 1974, 80:176-181
9. Witt MD, Lewis RJ, Larsen RA, Milefchick EN, Leal MAE, Haubrich RH, Richie JA, Edwards JEJ, Ghannoum MA: Identification of patients with acute AIDS-associated cryptococcal meningitis who can be effectively treated with fluconazole: the role of antifungal susceptibility testing. Clin Infect Dis 1996, 22:322-328
10. Chrétien F, Lortholary O, Kansau I, Neuville S, Gray F, Dromer F: Pathogenesis of cerebral Cryptococcus neoformans infection after fungemia. J Infect Dis 2002, 186:522-530
11. Lortholary O, Improvisi L, Nicolas M, Provost F, Dupont B, Dromer F: Fungemia during murine cryptococcosis sheds some light on pathophysiology. Med Mycol 1999, 37:169-174
12. Olszewski MA, Noverr MC, Chen GH, Toews GB, Cox GM, Perfect JR, Huffnagle GB: Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion. Am J Pathol 2004, 164:1761-1771
13. Chang YC, Kwon-Chung KJ: Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence. Mol Cell Biol 1994, 14:4912-4919
14. Chang YC, Penoyer LA, Kwon-Chung KJ: The second capsule gene of Cryptococcus neoformans, CAP64, is essential for virulence. Infect Immun 1996, 64:1977-1983
15. Chang YC, Kwon-Chung KJ: Isolation of the third capsule-associated gene CAP60, required for virulence in Cryptococcus neoformans. Infect Immun 1998, 66:2230-2236
16. Garcia-Rivera J, Chang YC, Kwon-Chung KJ, Casadevall A: Cryptococcus neoformans CAP59 (or Cap59p) is involved in the extracellular trafficking of capsular glucuronoxylomannan. Eukaryot Cell 2004, 3:385-392
17. Kozel TR, Levitz SM, Dromer F, Gates MA, Thorkildson P, Janbon G: Antigenic and biological characteristics of mutant strains of Cryptococcus neoformans lacking capsular O acetylation or xylosyl side chains. Infect Immun 2003, 71:2868-2875
18. Lortholary O, Improvisi L, Rayhane N, Gray F, Fitting C, Cavaillon JM, Dromer F: Cytokine profiles of AIDS patients are similar to those of mice with disseminated Cryptococcus neoformans infection. Infect Immun 1999, 67:6314-6320
19. Walenkamp AME, Scharringa J, Schramel FMNH, Coenjaerts FEJ, Hoepelman IM: Quantitative analysis of phagocytosis of Cryptococcus neoformans by adherent phagocytic cells by fluorescence multi-well plate reader. J Microbiol Methods 2000, 40:39-45
20. Stewart PA, Farrell CR, Farrell CL, Hayakawa E: Horseradish peroxidase retention and washout in blood-brain barrier lesions. J Neurosci Methods 1992, 41:75-84
21. Dromer F, Salamero J, Contrepois A, Carbon C, Yeni P: Production, characterization, and antibody specificity of a mouse monoclonal antibody reactive with Cryptococcus neoformans capsular polysaccharide. Infect Immun 1987, 55:742-748
22. Dromer F, Guého E, Ronin O, Dupont B: Serotyping of Cryptococcus neoformans by using a monoclonal antibody specific for capsular polysaccharide. J Clin Microbiol 1993, 31:359-363
23. Ikeda R, Nishimura S, Nishikawa A, Shinoda T: Production of agglutining monoclonal antibody against antigen 8 specific for Cryptococcus neoformans serotype D. Clin Diagn Lab Immunol 1996, 3:89-92
24. Tunkel AR, Scheld WM: Pathogenesis and pathophysiology of bacterial meningitis. Clin Microbiol Rev 1993, 6:118-136
25. Chang YC, Stins MF, McCaffery MJ, Miller GF, Pare DR, Dam T, Paul-Satyasee M, Kim KS, Kwon-Chung KJ: Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier. Infect Immun 2004, 72:4985-4995
26. Lee SC, Dickson DW, Casadevall A: Pathology of cryptococcal meningoencephalitis: analysis of 27 patients with pathogenetic implications. Hum Pathol 1996, 27:839-847
27. Noverr MC, Williamson PR, Fajardo RS, Huffnagle GB: CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence. Infect Immun 2004, 72:1693-1699
28. Chen SH, Stins MF, Huang SH, Chen YH, Kwon-Chung KJ, Chang Y, Kim KS, Suzuki K, Jong AY: Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells. J Med Microbiol 2003, 52:961-970
29. Luberto C, Martinez-Marino B, Taraskiewicz D, Bolanos B, Chitano P, Toffaletti DL, Cox GM, Perfect JR, Hannun YA, Balish E, Del Poeta M: Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. J Clin Invest 2003, 112:1080-1094
30. Santangelo R, Zoellner H, Sorrell T, Wilson C, Donald C, Djordjevic J, Shounan Y, Wright L: Role of extracellular phospholipases and mononuclear phagocytes in dissemination of cryptococcosis in a murine model. Infect Immun 2004, 72:2229-2239
31. Pierini LM, Doering TL: Spatial and temporal sequence of capsule construction in Cryptococcus neoformans. Mol Microbiol 2001, 41:105-115
32. Gates MA, Thorkildson P, Kozel TR: Molecular architecture of the Cryptococcus neoformans capsule. Mol Microbiol 2004, 52:13-24
33. Granger DL, Perfect JR, Durack DT: Virulence of Cryptococcus neoformans: regulation of capsule synthesis by carbon dioxide. J Clin Invest 1985, 76:508-516
34. Zaragoza O, Fries BC, Casadevall A: Induction of capsule growth in Cryptococcus neoformans by mammalian serum and CO(2). Infect Immun 2003, 71:6155-6164
35. Tucker SC, Casadevall A: Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm. Proc Natl Acad Sci USA 2002, 99:3165-3170
36. Feldmesser M, Kress Y, Casadevall A: Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infection. Microbiol 2001, 147:2355-2365
37. Pietrella D, Fries B, Lupo P, Bistoni F, Casadevall A, Vecchiarelli A: Phenotypic switching of Cryptococcus neoformans can influence the outcome of the human immune response. Cell Microbiol 2003, 5:513-522
38. Fries BC, Taborda CP, Serfass E, Casadevall A: Phenotypic switching of Cryptococcus neoformans occurs in vivo and influences the outcome of infection. J Clin Invest 2001, 108:1639-1648
39. Fries BC, Goldman DL, Cherniak R, Ju R, Casadevall A: Phenotypic switching in Cryptococcus neoformans results in change in cellular morphology and glucuronoxylomannan structure. Infect Immun 1999, 67:6076-6083
40. Garcia-Hermoso D, Dromer F, Janbon G: Cryptococcus neoformans capsule structure evolution in vitro and during murine infection. Infect Immun 2004, 72:3359-3365
41. Dromer F, Varma A, Ronin O, Mathoulin S, Dupont B: Molecular typing of Cryptococcus neoformans serotype D clinical isolates. J Clin Microbiol 1994, 32:2364-2371
42. Rivera J, Feldmesser M, Cammer M, Casadevall A: Organ-dependent variation of capsule thickness in Cryptococcus neoformans during experimental murine infection. Infect Immun 1998, 66:5027-5030
43. Dromer F, Mathoulin S, Dupont B, Letenneur L, Ronin O, the French Cryptococcosis Study Group: Individual and environmental factors associated with Cryptococcus neoformans serotype D infections in France. Clin Infect Dis 1996, 23:91-96
44. Solnick JV, Hansen LM, Salama NR, Boonjakuakul JK, Syvanen M: Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques. Proc Natl Acad Sci USA 2004, 101:2106-2111
45. Flick K, Chen Q: var genes, PfEMP1, and the human host. Mol Biochem Parasitol 2004, 134:3-9
46. Jodar L, Feavers IM, Salisbury D, Granoff DM: Development of vaccines against meningococcal disease. Lancet 2002, 359:1499-1508
47. Lortholary O, Dromer F, Mathoulin-Pélissier S, Fitting C, Improvisi L, Cavaillon JM, Dupont B, the French Cryptococcosis Study Group: Immune mediators in cerebrospinal fluid are influenced by meningeal involvement and human immunodeficiency virus serostatus during Cryptococcus neoformans infection. J Infect Dis 2001, 183:294-302
48. Mukherjee J, Casadevall A, Scharff MD: Molecular characterization of the humoral responses to Cryptococcus neoformans infection and glucuronoxylomannan- tetanus toxoid conjugate immunization. J Exp Med 1993, 177:1105-1116
49. Fleuridor R, Lyles RH, Pirofski L: Quantitative and qualitative differences in the serum antibody profiles of human immunodeficiency virus-infected persons with and without Cryptococcus neoformans meningitis. J Infect Dis 1999, 180:1526-1535
50. Steen BR, Zuyderduyn S, Toffaletti DL, Marra M, Jones SJ, Perfect JR, Kronstad J: Cryptococcus neoformans gene expression during experimental cryptococcal meningitis. Eukaryot Cell 2003, 2:1336-1349
51. Janbon G, Himmelreich U, Moyrand F, Improvisi L, Dromer F: CAS1 is a membrane protein necessary for the O-acetylation of the Cryptococcus neoformans capsular polysaccharide. Mol Microbiol 2001, 42:453-469
52. Bar-Peled M, Griffith CL, Doering TL: Functional cloning and characterization of a UDP-glucuronic acid decarboxylase: the pathogenic fungus Cryptococcus neoformans elucidates UDP-xylose synthesis. Proc Natl Acad Sci USA 2001, 98:12003-12008
53. Moyrand F, Klaproth B, Himmelreich U, Dromer F, Janbon G: Isolation and characterization of capsule structure mutant strains of Cryptococcus neoformans. Mol Microbiol 2002, 45:837-849
54. Freitas-Junior LH, Bottius E, Pirrit LA, Deitsch KW, Scheidig C, Guinet F, Nehrbass U, Wellems TE, Scherf A: Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum. Nature 2000, 407:1018-1022
55. del Portillo HA, Fernandez-Becerra C, Bowman S, Oliver K, Preuss M, Sanchez CP, Schneider NK, Villalobos JM, Rajandream MA, Harris D, Pereira da Silva LH, Barrell B, Lanzer M: A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax. Nature 2001, 410:839-842
56. Sunkin SM, Stringer JR: Translocation of surface antigen genes to a unique telomeric expression site in Pneumocystis carinii. Mol Microbiol 1996, 19:283-295
57. Janbon G: Cryptococcus neoformans capsule biosynthesis and regulation. FEMS Yeast Res 2004, 4:765-771
58. Casadevall A, Pirofski L: Microbial virulence results from the interaction between host and microorganism. Trends Microbiol 2003, 11:157-158
59. Buchanan KL, Murphy JW: What makes Cryptococcus neoformans a pathogen? Emerg Infect Dis 1998, 4:71-83