Control of Borrelia burgdorferi-speciftc CD4+-T-cell effector function by interleukin-12- and T-cell receptor-induced p38 mitogen-activated protein kinase activity

Infection and Immunity

Volumn 74, Issue 10, 2006, Pages 5713-5717

  Hedrick, Michael N ^a   Olson Jr , Chris M ^b   Conze, Dietrich B ^c,d   Bates, Tonya C ^a,b   Rincoń, Mercedes ^c   Anguita, Juan ^a,b  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

^c UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BORRELIA BURGDORFERI; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; FEMALE; LYME DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL;

ANIMALS; ANTIGENS, CD4; BORRELIA BURGDORFERI; FEMALE; INTERFERON TYPE II; INTERFERON-GAMMA; INTERLEUKIN-12; LYME DISEASE; MAP KINASE KINASE 3; MICE; MICE, INBRED STRAINS; MUTATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; RECEPTORS, ANTIGEN, T-CELL; TH1 CELLS;

EID: 33749237881     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00623-06     Document Type: Article

References (27)

1. Anguita, J., S. W. Barthold, R. Persinski, M. N. Hedrick, C. A. Huy, R. J. Davis, R. A. Flavell, and E. Fikrig. 2002. Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. J. Immunol. 168:6352-6357.
2. Anguita, J., M. N. Hedrick, and E. Fikrig. 2003. Adaptation of Borrelia burgdorferi in the tick and the mammalian host. FEMS Microbiol. Rev. 27:493-504.
3. Anguita, J., D. H. Persing, M. Rincón, S. W. Barthold, and E. Fikrig. 1996. Effect of anti-interleukin 12 treatment on murine Lyme borreliosis. J. Clin. Investig. 97:1028-1034.
4. Anguita, J., V. Thomas, S. Samanta, R. Persinski, C. Hernanz, S. W. Barthold, and E. Fikrig. 2001. Borrelia burgdorferi-induced inflammation facilitates spirochete adaptation and variable major protein-like sequence locus recombination. J. Immunol. 167:3383-3390.
5. Badger, A. M., J. N. Bradbeer, B. Votta, J. C. Lee, J. L. Adams, and D. E. Griswold. 1996. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol. Exp. Ther. 279:1453-1461.
6. Barthold, S. W. 1991. Infectivity of Borrelia burgdorferi relative to route of inoculation and genotype in laboratory mice. J. Infect. Dis. 163:419-420.
7. Behera, A. K., E. Hildebrand, R. T. Bronson, G. Perides, S. Uematsu, S. Akira, and L. T. Hu. 2006. MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi. Infect. Immun. 74:1462-1470.
8. Berenson, L. S., J. Yang, B. P. Sleckman, T. L. Murphy, and K. M. Murphy. 2006. Selective requirement of p38{alpha} MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses. J. Immunol. 176:4616-4621.
9. Bolz, D. D., R. S. Sundsbak, Y. Ma, S. Akira, C. J. Kirschning, J. F. Zachary, J. H. Weis, and J. J. Weis. 2004. MyD88 plays a unique role in host defense but not arthritis development in Lyme disease. J. Immunol. 173:2003-2010.
10. Brown, C. R., and S. L. Reiner. 1999. Experimental Lyme arthritis in the absence of interleukin-4 or gamma interferon. Infect. Immun. 67:3329-3333.
11. Chi, H., B. Lu, M. Takekawa, R. J. Davis, and R. A. Flavell. 2004. GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J. 23:1576-1586.
12. de Souza, M. S., A. L. Smith, D. S. Beck, L. J. Kim, G. M. Hansen, Jr., and S. W. Barthold. 1993. Variant responses of mice to Borrelia burgdorferi depending on the site of intradermal inoculation. Infect. Immun. 61:4493-4497.
13. Glickstein, L., M. Edelstein, and J. Z. Dong. 2001. Gamma interferon is not required for arthritis resistance in the murine Lyme disease model. Infect. Immun. 69:3737-3743.
14. Gross, D. M., A. C. Steere, and B. T. Huber. 1998. T helper 1 response is dominant and localized to the synovial fluid in patients with Lyme arthritis. J. Immunol. 160:1022-1028.
15. Keane-Myers, A., and S. P. Nickell. 1995. Role of IL-4 and IFN-gamma in modulation of immunity to Borrelia burgdorferi in mice. J. Immunol. 155:2020-2028.
16. Liu, N., R. R. Montgomery, S. W. Barthold, and L. K. Bockenstedt. 2004. Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected mice. Infect. Immun. 72:3195-3203.
17. Lu, B., H. Yu, C. Chow, B. Li, W. Zheng, R. J. Davis, and R. A. Flavell. 2001. GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. Immunity 14:583-590.
18. Lu, H. T., D. D. Yang, M. Wysk, E. Gatti, I. Mellman, R. J. Davis, and R. A. Flavell. 1999. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18:1845-1857.
19. Matyniak, J. E., and S. L. Reiner. 1995. T helper phenotype and genetic susceptibility in experimental Lyme disease. J. Exp. Med. 181:1251-1254.
20. McCabe, G. J., and J. E. Bunnell. 2004. Precipitation and the occurrence of Lyme disease in the northeastern United States. Vector Borne Zoonotic Dis. 4:143-148.
21. Morinobu, A., M. Gadina, W. Strober, R. Visconti, A. Fornace, C. Montagna, G. M. Feldman, R. Nishikomori, and J. J. O'Shea. 2002. STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. Proc. Natl. Acad. Sci. USA 99:12281-12286.
22. Motameni, A. R., T. C. Bates, I. J. Juncadella, C. Petty, M. N. Hedrick, and J. Anguita. 2005. Distinct bacterial dissemination and disease outcome in mice subcutaneously infected with Borrelia burgdorferi in the midline of the back and the footpad. FEMS Immunol. Med. Microbiol. 45:279-284.
23. Rincón, M., H. Enslen, J. Raingeaud, M. Recht, T. Zapton, M. S. Su, L. A. Penix, R. J. Davis, and R. A. Flavell. 1998. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J. 17:2817-2829.
24. Subak, S. 2003. Effects of climate on variability in Lyme disease incidence in the northeastern United States. Am. J. Epidemiol. 157:531-538.
25. Sun, D., and A. Ding. 2006. MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA. Nat. Immunol. 7:375-381.
26. Van Solingen, R. M., and J. Evans. 2001. Lyme disease. Curr. Opin. Rheumatol. 13:293-299.
27. Zhang, S., and M. H. Kaplan. 2000. The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-gamma expression. J. Immunol. 165:1374-1380.