Evaluation of ex vivo human skin permeation of genistein and daidzein

Drug Delivery

Volumn 13, Issue 6, 2006, Pages 411-415

  Minghetti, Paola ^a   Cilurzo, Francesco ^a   Casiraghi, Antonella ^a   Montanari, Luisa ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Genistein; Skin Permeation; Soy Extract

Indexed keywords

DAIDZEIN; DIETHYLENE GLYCOL MONOETHYL ETHER; GENIMAX; GENISTEIN; LABRASOL; MACROGOL; MACROGOL 400; OLEIC ACID;

ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG EFFICACY; DRUG PENETRATION; EPIDERMIS; ESTROGEN ACTIVITY; EVALUATION; EX VIVO STUDY; HUMAN; HUMAN TISSUE; PLASMA; PRIORITY JOURNAL; SKIN PERMEABILITY; STEADY STATE;

CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIFFUSION CHAMBERS, CULTURE; EPIDERMIS; ESTROGENS, NON-STEROIDAL; GENISTEIN; HUMANS; ISOFLAVONES; PHARMACEUTICAL VEHICLES; PHYSICOCHEMICAL PHENOMENA; PLANT EXTRACTS; POLYETHYLENE GLYCOLS; SKIN ABSORPTION; SOLUBILITY; SOYBEANS; VEHICLES;

EID: 33749124125     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540500466089     Document Type: Article

References (26)

1. Albertazzi, P., and Purdie, D. W. 2002. The nature and utility of the phytoestrogens: a review of the evidence. Maturitas 42:173-185.
2. Anderson, J. M., Johnstone, B. M., and Cook-Newell, M. E. 1995. Meta-analysis of soy protein intake on serum lipids. N. Engl. J. Med. 333:276-282.
3. Arjmandi, B. H., Alekel, L., Hollis, B. W., et al. 1996. Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. J. Nutr. 126:161-167.
4. Arjmandi, B. H., and Smith, B. J. 2002. Soy isoflavones' osteoprotective role in postmenopausal women: mechanism of action. J. Nutr. Biochem. 13:130-137.
5. Bloedon, L., Jeffcoat, A. R., Lopaczynski, W., et al. 2002. Safety and pharmacokinetics of purified soy isoflavones: single dose administration to postmenopausal women. Am. J. Clin. Nutr. 76:1126-1137.
6. Bovee, T. F. H., Helsdinger, R. J. R., Rietjens, I. M. C. M., et al. 2004. Rapid yeast bioassays stably expressing human estrogen receptors α and β, and green fluorescent protein: a comparison of different compounds with both receptor types. J. Steroid Biochem. Mol. Biol. 91:99-109.
7. Faughnan, M. S., Hawdon, A., Ah-Singh, E., et al. 2004. Urinary isoflavone kinetics: the effect of age, gender, food matrix and chemical composition. Br. J. Nutr. 91:567-574.
8. Fritz, W. A., Coward, L., Wang, J., and Lamamrtiniere, C. A. 1998. Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenenesis 19:2151-2158.
9. Gaillard, P., Carrupt, P. A., Testa, B., and Boudon, A. 1994. Molecular lipophilicity potential in 3D-QSAR: method and applications. J. Comput. Aided Mol. Design 8:83-96.
10. Glazier, M. G., and Bowman, M. 2001. A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch. Intern. Med. 161:1161-1172.
11. Jacobsen, B. K., Knutsen, S. F., and Fraer, G. E. 1998. Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States). Cancer Causes Control 9:553-557.
12. Kreijkamp-Kasper, S., Kok, L., Grobbee, D. E., et al. 2004. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, plasma lipids in postmenopausalwomen: a randomized controlled trial. JAMA 292:65-74.
13. Kuiper, G., Carlsson, B., Grandien, K., et al. 1997. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors and α and β. Endocrinology 138:863-870.
14. Lee, H. P., Gourley, L., Duffy, S. W., et al. 1991. Dietary effects on breast-cancer risk in Singapore. Lancet 337:1197-1200.
15. Minghetti, P., Casiraghi, A., Cilurzo, F., et al. 1999a. Comparison of different membranes with cultures of keratinocytes from man for percutaneous absorption of nitroglycerin. J. Pharm. Pharmacol. 51:729-734.
16. Minghetti, P., Casiraghi, A., Montanari, L., and Monzani, M. V. 1999b. In vitro skin permeation of Sinitrodil, a member of a new class of nitrovasodilator drugs. Eur. J. Pharm. Sci. 7:231-236.
17. Minghetti, P., Cilurzo, F., Casiraghi, A., et al. 2001. Development of patches for the controlled release of dehydroepiandrosterone. Drug Dev. Ind. Pharm. 27:113-119.
18. Pedretti, A., Villa, L., and Vistoli, G. 2002. VEGA: A versatile program to convert, handle and visualize molecular structure on windows-based PCs. J. Mol. Graph. 21:47-49.
19. Scarabin, P., Alhenc-Gelas, M., Plu-Bureau, G., et al. 1997. Effects of oral and transdermal estrogen/progesterone regimens on blood coagulation and fibrinolysis in postmenopausal women: a randomized controlled trial. Arterioscler. Thromb. Vasc. Biol. 17:e3071-e3078.
20. Setchell, K., Brown, N. M., Desai, P., et al. 2001. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavones supplements. J. Nutr. 131:1362S-1375S.
21. Setchell, K., Brown, N. M., Desai, P., et al. 2003a. Bioavailability disposition and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes. J. Nutr. 133:1027-1035.
22. Setchell, K., Faughnan, M. S., Avades, T., et al. 2003b. Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracer in premenopaual women. Am. J. Clin. Nutr. 77:411-419.
23. Squadrito, F., Altavilla, D., Crisafulli, A., et al. 2003. Effect of genistein on endothelial function in postmenopausal women: a randomized, double blind, controlled study. Am. J. Med. 144:470-476.
24. Vanttnen, K., and Moravcova, J. 2001. Transdermal absorption of phytoestrogens. Pharmazie 56:711-717.
25. Zhang, Y., Wang, G. J., Song, T., et al. 1999. Urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differ among humans with moderate fecal isoflavone degradation activity. J. Nutr. 129:957-962.
26. Zubik, L., and Meydani, M. 2003. Bioavailability of soybean isoflavones from aglycone and glucoside forms in American women. Am. J. Clin. Nutr. 77:1459-1465.