State-based discovery: A multidimensional screen for small-molecule modulators of EGF signaling

Nature Methods

Volumn 3, Issue 10, 2006, Pages 825-831

  Sevecka, Mark ^a   MacBeath, Gavin ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATASE INHIBITOR; PROTEIN KINASE B; PYROXYLIN; RK 682; UNCLASSIFIED DRUG; WORTMANNIN;

ANTIBODY SCREENING; ARTICLE; CELL IMMORTALIZATION; CLUSTER ANALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS REACTION; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MICROARRAY ANALYSIS; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VALIDATION STUDY;

ANTIBODIES; ANTIGEN-ANTIBODY REACTIONS; CELL LINE; CLUSTER ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; HUMANS; PEPTIDE LIBRARY; PROTEIN ARRAY ANALYSIS; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33749037412     PISSN: 15487091     EISSN: 15491676     Source Type: Journal    
DOI: 10.1038/nmeth931     Document Type: Article

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