Interaction of riluzole with the closed inactivated state of Kv4.3 channels

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 1, 2006, Pages 323-331

  Hye, Sook Ahn ^a   Sung, Eun Kim ^a   Jang, Hyun Jong ^a   Kim, Myung Jun ^a   Rhie, Duck Joo ^a   Yoon, Shin Hee ^a   Jo, Yang Hyeok ^a   Kim, Myung Suk ^a   Sung, Ki Wug ^a   Sang, June Hahn ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

RILUZOLE; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFECT; DRUG MECHANISM; ELECTROPHYSIOLOGY; FEMALE; HYPERPOLARIZATION; IC 50; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; STEADY STATE;

ANIMALS; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; NEUROPROTECTIVE AGENTS; POTASSIUM CHANNEL BLOCKERS; RILUZOLE; SHAL POTASSIUM CHANNELS;

EID: 33749000921     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.106724     Document Type: Article

References (40)

1. + channels, Kv1.5 and Kv3.1, by riluzole. Neuroscience 133:1007-1019.
2. Bahring R, Boland LM, Varghese A, Gebauer M, and Pongs O (2001) Kinetic analysis of open- and closed-state inactivation transitions in human Kv4.2 A-type potassium channels. J Physiol (Lond) 535:65-81.
3. Bean BP, Cohen CJ, and Tsien RW (1983) Lidocaine block of cardiac sodium channels. J Gen Physiol 81:613-642.
4. Beck EJ, Bowlby M, An WF, Rhodes KJ, and Covarrubias M (2002) Remodelling inactivation gating of Kv4 channels by KChIP1, a small-molecular-weight calcium-binding protein. J Physiol (Lond) 538:691-706.
5. Beck EJ and Covarrubias M (2001) Kv4 channels exhibit modulation of closed-state inactivation in inside-out patches. Biophys J 81:867-883.
6. Benoit E and Escande D (1991) Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre. Pflueg Arch Eur J Physiol 419:603-609.
7. Bett GC, Morales MJ, Strauss HC, and Rasmusson RL (2006) KChIP2b modulates the affinity and use-dependent block of Kv4.3 by nifedipine. Biochem Biophys Res Commun 340:1167-1177.
8. Bryson HM, Fulton B, and Benfield P (1996) Riluzole. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis. Drugs 52:549-563.
9. Campbell DL, Qu Y, Rasmusson RL, and Strauss HC (1993) The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. II. Closed state reverse use-dependent block by 4-aminopyridine. J Gen Physiol 101:603-626.
10. Cao YJ, Dreixler JC, Couey JJ, and Houamed KM (2002) Modulation of recombinant and native neuronal SK channels by the neuroprotective drug riluzole. Eur J Pharmacol 449:47-54.
11. Centonze D, Calabresi P, Pisani A, Marinelli S, Marfia GA, and Bernardi G (1998) Electrophysiology of the neuroprotective agent riluzole on striatal spiny neurons. Neuropharmacology 37:1063-1070.
12. Choi BH, Choi JS, Min DS, Yoon SH, Rhie DJ, Jo YH, Kim MS, and Hahn SJ (2001) Effects of (-)-epigallocatechin-3-gallate, the main component of green tea, on the cloned rat brain Kv1.5 potassium channels. Biochem Pharmacol 62:527-535.
13. + channel behaves like an open-channel blocker. Neuron 7:743-753.
14. Doble A (1996) The pharmacology and mechanism of action of riluzole. Neurology 47:S233-S241.
15. Duprat F, Lesage F, Patel AJ, Fink M, Romey G, and Lazdunski M (2000) The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK. Mol Pharmacol 57:906-912.
16. Grunnet M, Jespersen T, Angelo K, Frokjaer-Jensen C, Klaerke DA, Olesen SP, and Jensen BS (2001) Pharmacological modulation of SK3 channels. Neuropharmacology 40:879-887.
17. He Y, Benz A, Fu T, Wang M, Covey DF, Zorumski CF, and Mennerick S (2002) Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function. Neuropharmacology 42:199-209.
18. Hoffman DA and Johnston D (1998) Downregulation of transient K+ channels in dendrites of hippocampal CA1 pyramidal neurons by activation of PKA and PKC. J Neurosci 18:3521-3528.
19. Huang CS, Song JH, Nagata K, Yeh JZ, and Narahashi T (1997) Effects of the neuroprotective agent riluzole on the high voltage-activated calcium channels of rat dorsal root ganglion neurons. J Pharmacol Exp Ther 282:1280-1290.
20. Jerng HH and Covarrubias M (1997) K+ channel inactivation mediated by the concerted action of the cytoplasmic N- and C-terminal domains. Biophys J 72:163-174.
21. Kirsch GE, Yeh JZ, and Oxford GS (1986) Modulation of aminopyridine block of potassium currents in squid axon. Biophys J 50:637-644.
22. Kuo CC and Bean BP (1994) Na+ channels must deactivate to recover from inactivation. Neuron 12:819-829.
23. Lee TE, Philipson LH, and Nelson DJ (1996) N-type inactivation in the mammalian Shaker K+ channel Kv1.4. J Membr Biol 151:225-235.
24. Le Liboux A, Lefebvre P, Le Roux Y, Truffinet P, Aubeneau M, Kirkesseli S, and Montay G (1997) Single- and multiple-dose pharmacokinetics of riluzole in white subjects. J Clin Pharmacol 37:820-827.
25. Ohya S, Tanaka M, Oku T, Asai Y, Watanabe M, Giles WR, and Imaizumi Y (1997) Molecular cloning and tissue distribution of an alternatively spliced variant of an A-type K+ channel alpha-subunit, Kv4.3 in the rat. FEBS Lett 420:47-53.
26. Romettino S, Lazdunski M, and Gottesmann C (1991) Anticonvulsant and sleep-waking influences of riluzole in a rat model of absence epilepsy. Eur J Pharmacol 199:371-373.
27. Ruppersberg JP, Frank R, Pongs O, and Stocker M (1991a) Cloned neuronal IK(A) channels reopen during recovery from inactivation. Nature (Lond) 353:657-660.
28. Ruppersberg JP, Stocker M, Pongs O, Heinemann SH, Frank R, and Koenen M (1991b) Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation. Nature (Lond) 352:711-714.
29. + (A-type) currents in rat brain. J Neurophysiol 79:1081-1091.
30. + channel proteins in rat central neurons. Neuron 9:271-284.
31. Snyders DJ, Tamkun MM, and Bennett PB (1993) A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression. J Gen Physiol 101:513-543.
32. Stephens GJ, Owen DG, and Robertson B (1996) Cysteine-modifying reagents alter the gating of the rat cloned potassium channel Kv1.4. Pflueg Arch Eur J Physiol 431:435-442.
33. Stutzmann JM, Bohme GA, Gandolfo G, Gottesmann C, Lafforgue J, Blanchard JC, Laduron PM, and Lazdunski M (1991) Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dendrotoxin I in the rat. Eur J Pharmacol 193:223-229.
34. + channels as targets for neuroprotective drugs. Trends Pharmacol Sci 16:309-316.
35. Urbani A and Belluzzi O (2000) Riluzole inhibits the persistent sodium current in mammalian CNS neurons. Eur J Neurosci 12:3567-3574.
36. Wang S, Bondarenko VE, Qu YJ, Bett GC, Morales MJ, Rasmusson RL, and Strauss HC (2005) Time- and voltage-dependent components of Kv4.3 inactivation. Biophys J 89:3026-3041.
37. Wu SN and Li HF (1999) Characterization of riluzole-induced stimulation of large-conductance calcium-activated potassium channels in rat pituitary GH3 cells. J Investig Med 47:484-495.
38. Xu L, Enyeart JA, and Enyeart JJ (2001) Neuroprotective agent riluzole dramatically slows inactivation of Kv1.4 potassium channels by a voltage-dependent oxidative mechanism. J Pharmacol Exp Ther 299:227-237.
39. + channels in hippocampus involves a mitogen-activated protein kinase pathway. J Neurosci 22:4860-4868.
40. Zona C, Siniscalchi A, Mercuri NB, and Bernardi G (1998) Riluzole interacts with voltage-activated sodium and potassium currents in cultured rat cortical neurons. Neuroscience 85:931-938.