Neuroprotective agent riluzole potentiates postsynaptic GABAA receptor function

Neuropharmacology

Volumn 42, Issue 2, 2002, Pages 199-209

  He, Y ^a   Benz, A ^a   Fu, T ^a   Wang, M ^a   Covey, D F ^a   Zorumski, C F ^a   Mennerick, S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

GABAA receptors; Inhibitory postsynaptic current; Lactone; Potentiation; Riluzole

Indexed keywords

(3ALPHA,5ALPHA) 3 HYDROXYPREGNAN 20 ONE; 1 [2 (BENZHYDRYLIDENEAMINOOXY)ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; 3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; ALPHA ISOPROPYL ALPHA METHYL GAMMA BUTYROLACTONE; BICUCULLINE; FLUMAZENIL; GAMMA BUTYROLACTONE DERIVATIVE; LORAZEPAM; NEUROSTEROID; PENTOBARBITAL; RILUZOLE; SODIUM CHANNEL; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; ELECTROPHYSIOLOGY; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIAL; NEUROPROTECTION; NEWBORN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; XENOPUS;

ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA AGONISTS; GABA ANTAGONISTS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; NEUROPROTECTIVE AGENTS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RILUZOLE; SYNAPSES; XENOPUS;

EID: 0036166936     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00175-7     Document Type: Article

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