Effect of nepadutant at tachykinin NK2 receptors in human intestine and urinary bladder

European Journal of Pharmacology

Volumn 398, Issue 3, 2000, Pages 389-397

  Patacchini, Riccardo ^a   Giuliani, Sandro ^a   Turini, Alessandro ^b   Navarra, Giuseppe ^b   Maggi, Carlo Alberto ^a  

^a Menarini Ricerche SpA   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

Intestine, human; Nepadutant; Tachykinin receptor; Tachykinin receptor antagonist; Urinary bladder, human

Indexed keywords

ATROPINE; CARBACHOL; GUANETHIDINE; N(G) NITROARGININE METHYL ESTER; NEPADUTANT; NEUROKININ 2 RECEPTOR; NOLPITANTIUM; PHYSALAEMIN[9 DEXTRO PROLINE SPIRO GAMMA LACTAM 10 LEUCINE 11 TRYPTOPHAN]; SAREDUTANT; TACHYKININ RECEPTOR; TETRODOTOXIN;

ARTICLE; BLADDER EPITHELIUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE EPITHELIUM; MALE; MUSCLE CONTRACTILITY; PRIORITY JOURNAL; RECEPTOR BLOCKING;

AGED; AGED, 80 AND OVER; BENZAMIDES; COLON; FEMALE; HUMANS; ILEUM; MALE; MIDDLE AGED; NEUROKININ A; PEPTIDES, CYCLIC; PIPERIDINES; RECEPTORS, NEUROKININ-2; URINARY BLADDER;

EID: 0034705759     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00346-0     Document Type: Article

References (39)

1. 2) receptor revisited with SR 48968, a potent non-peptide antagonist. Biochem. Biophys. Res. Commun. 184:1992;1418-1424.
2. Arunlakshana O., Schild H.O. Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother. 14:1959;48-58.
3. Catalioto R.-M., Criscuoli M., Cucchi P., Giachetti A., Giannotti D., Giuliani S., Lecci A., Lippi A., Patacchini R., Quartara L., Renzetti A.R., Tramontana M., Arcamone F., Maggi C.A. MEN 11420 (Nepadutant), a novel glycosylated bicyclic peptide tachykinin NK2 receptor antagonist. Br. J. Pharmacol. 123:1998;1-91.
4. 2 receptor antagonists, SR 140333 and SR 48968 in different rat and guinea pig intestinal segments. Life Sci. 56:1995;267-275.
5. 2-receptors modulating motor responses of human colonic muscle strips. Br. J. Pharmacol. 124:1998;1321-1327.
6. 2 receptor. Br. J. Pharmacol. 125(74P):1998.
7. 2) receptor. Life Sci. 50:1992;101-106.
8. 2) receptor antagonist. Regul. Pept. 46:1993;31-36.
9. 1 receptor antagonist. Eur. J. Pharmacol. 250:1993;403-413.
10. 2 receptor subtype. Eur. J. Pharmacol. 203:1991;365-370.
11. Giuliani S., Patacchini R., Barbanti G., Turini D., Rovero P., Quartara L., Giachetti A., Maggi C.A. Characterization of the tachykinin neurokinin-2 receptor in the human urinary bladder by means of selective receptor antagonists and peptidase inhibitors. J. Pharmacol. Exp. Ther. 267:1993;590-595.
12. 2 receptor antagonists in the human isolated urinary bladder. J. Auton. Pharmacol. 16:1996;251-259.
13. Guard S., Watson S.P. Tachykinin receptor types: classification and membrane signalling mechanisms. Neurochem. Int. 18:1991;149-165.
14. 1 receptor antagonist. Br. J. Pharmacol. 102:1991;168.
15. Holzer P. Tachykinins as targets of gastroenterological pharmacotherapy. Drug News & Perspect. 11:1998;394-401.
16. Holzer P., Holzer-Petsche U. Tachykinins in the gut: Part I. Expression, release, and motor function. Pharmacol. Ther. 73:1997;173-217.
17. 2 receptors. Eur. J. Pharmacol. 239:1993;103-109.
18. Jenkinson D.H. How we describe competitive antagonists: three questions of usage. Trends Pharmacol. Sci. 12:1991;53-56.
19. Kenakin T.P. Pharmacologic Analysis of Drug-Receptor Interaction. 3rd edn. 1997;Lippincott-Raven, Philadelphia.
20. 2 receptor antagonist MEN 11420 (nepadutant) in rats. Drug Metab. Dispos. 26:1998;1077-1081.
21. Maggi C.A. Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves. Prog. Neurobiol. 45:1995;1-98.
22. Maggi C.A. The mammalian tachykinin receptors. Gen. Pharmacol. 26:1995;911-944.
23. 2 receptors. Eur. J. Pharmacol. 145:1988;335-340.
24. Maggi C.A., Patacchini R., Santicioli P., Giuliani S., Turini D., Barabanti G., Giachetti A., Meli A. Human isolated ileum: motor responses of the circular muscle to electrical field stimulation and exogenous neuropeptides. Naunyn-Schmiedeberg's Arch. Pharmacol. 341:1990;256-261.
25. Maggi C.A., Giuliani S., Patacchini R., Santicioli P., Theodorsson E., Barbanti G., Turini D., Giachetti A. Tachykinin antagonists inhibit nerve-mediated contractions in the circular muscle of the human ileum. Gastroenterology. 102:1992;88-96.
26. 2 receptor antagonist. Eur. J. Pharmacol. 234:1993;83-90.
27. Maggi C.A., Patacchini R., Rovero P., Giachetti A. Tachykinin receptors and tachykinin receptor subtypes. J. Auton. Pharmacol. 13:1993;23-93.
28. 2 receptors. J. Pharmacol. Exp. Ther. 271:1994;1489-1500.
29. 2 receptors in the circular muscle of the guinea pig ileum and proximal colon. Br. J. Pharmacol. 112:1994;150-160.
30. 2 receptors in producing fast and slow atropine-resistant neurotransmission to the circular muscle of the guinea pig colon. Neuroscience. 63:1994;1137-1152.
31. 2 receptor blockade by SR 48968 and MEN 10627 in the guinea pig isolated gallbladder and colon. Eur. J. Pharmacol. 271:1994;111-119.
32. 2 receptor antagonists in the human isolated ileum and colon. Neuropeptides. 31:1997;71-77.
33. Regoli D., Drapeau G., Dion S., D'orleans-Juste P. Receptors for substance P and related neurokinins. Pharmacology. 38:1989;1-15.
34. 2 receptor. Biochem. Biophys. Res. Commun. 248:1998;78-82.
35. 2 receptor antagonist, in guinea pigs. Eur. J. Pharmacol. 352:1998;279-288.
36. Von Sprecher A., Gerspacher M., Anderson G.P. Neurokinin antagonists as potential therapies for inflammation and rheumatoid arthritis. IDrugs. 1:1998;73-91.
37. 125I]-neurokinin A binding site in the circular muscle of human colon. Br. J. Pharmacol. 127:1999;1105-1110.
38. 2 receptors mediate non-adrenergic non-cholinergic excitatory neuromuscular transmission in the human ileum. Neuropeptides. 31:1997;265-271.
39. 2 receptors in human urinary bladder. J. Urol. 153:1995;1688-1692.