Nepadutant pharmacokinetics and dose-effect relationships as tachykinin NK2 receptor antagonist are altered by intestinal inflammation in rodent models

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 1, 2001, Pages 247-254

  Lecci, Alessandro ^a   Carini, Francesca ^a   Tramontana, Manuela ^a   D'Aranno, Vincenzo ^b   Marinoni, Erica ^b   Crea, Attilio ^b   Bueno, Lionel ^c   Fioramonti, Jean ^c   Criscuoli, Marco ^a   Giuliani, Sandro ^a   Maggi, Carlo Alberto ^a  

^a Pharmacology Department   (Italy)

^b Pharmacokinetics Department   (Italy)

^c CEMAGREF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; BACTERIAL TOXIN; CASTOR OIL; NEPADUTANT; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ A [4-10];

ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLADDER CONTRACTION; COLON MOTILITY; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; ENTERITIS; INTESTINE ABSORPTION; INTESTINE MOTILITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETIC ACIDS; ANIMALS; ANTIDIARRHEALS; BIOLOGICAL AVAILABILITY; CASTOR OIL; CATHARTICS; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTERITIS; GASTROINTESTINAL MOTILITY; MALE; MICE; MUSCLE, SMOOTH; NEUROKININ A; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-2; URINARY BLADDER;

EID: 0034802383     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Pharmacokinetics and pharmacodynamics of vecuronium in rats with systemic inflammatory response syndrome: Treatment with NG-monomethyl-L-arginine
2. 2 receptor antagonist
3. Intestinal water and electrolyte transport. Mechanisms of physiological and adaptive responses
4. 2 receptors in rats
5. Role of tachykinins in castor oil diarrhoea in rats
6. 2 receptor antagonist nepadutant in acute rectocolitis induced by diluted acetic acid in guinea-pigs
7. 2 receptor in rat colonic hypersecretion induced by interleukin 1β: Role of nitric oxide
8. Rectal distension-induced colonic net water secretion in rats involves tachykinins, capsaicin sensory and vagus nerves
9. Colitis and colonic mucosal barrier dysfunction
10. Tachykinins and reflexly evoked atropine-resistant motility in the guinea-pig colon in vivo
11. Tachykinin receptor mediate atropine-resistant rat duodenal contractions in vivo
12. On the specificity of altered muscle function in experimental colitis in rats
13. Experimental colitis increases blood-brain barrier permeability in rabbits
14. Tachykinins as targets of gastroenterological pharmacotherapy
15. Tachykinins in the gut. Part I. Expression, release and motor function
16. Tachykinins in the gut. Part II. Roles in neural excitation, secretion and inflammation
17. 2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro
18. 2 receptor antagonist, MEN11420 on proto-oncogene expression following experimental colitis
19. 2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs
20. 1 and NK2 receptors on colonic motility in anaesthetized rats: Effect of agonists
21. Principles of tachykininergic co-transmission in the peripheral and enteric nervous system
22. Comparative effects of nonpeptide tachykinin receptor antagonists on experimental inflammation in rats and guinea-pigs
23. Acute experimental colitis decreases colonic circular smooth muscle contractility in rats
24. Visceral pain and referred hyperalgesia in rats with colonic inflammation: Role of tachykinins
25. 2 tachykinin receptors to propulsion in the rabbit distal colon
26. The effect of endotoxin administration on the pharmacokinetics of chlorzoxazone in humans
27. Distribution of neurokinin-2 receptors in the guinea-pig intestinal tract
28. 2 receptors in normal and altered rectal sensitivity in rats
29. 2 receptor selective antagonist MEN 10,627 in rat small intestine
30. A novel motility effect of tachykinins in normal and inflamed colon
31. 2 tachykinin receptors and substance P in nerve endings of guinea-pig ileum