Vitamin K deficiency reduces testosterone production in the testis through down-regulation of the Cyp11a a cholesterol side chain cleavage enzyme in rats

Biochimica et Biophysica Acta - General Subjects

Volumn 1760, Issue 10, 2006, Pages 1482-1488

  Shirakawa, Hitoshi ^a   Ohsaki, Yusuke ^a   Minegishi, Yoshihiko ^a   Takumi, Naofumi ^a   Ohinata, Kousaku ^a   Furukawa, Yuji ^a   Mizutani, Takeo ^b   Komai, Michio ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b ALA Research Center   (Japan)

Author keywords

Cyp11a; Steroidogenesis; Testis; Testosterone; Vitamin K

Indexed keywords

CHOLESTEROL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450; CYTOCHROME P450 11A; LUTEINIZING HORMONE; MENATETRENONE; MESSENGER RNA; STEROID HORMONE; TESTOSTERONE; UNCLASSIFIED DRUG; VITAMIN K GROUP;

ANIMAL TISSUE; ARTICLE; CHOLESTEROL SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION; GENE IDENTIFICATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; STEROIDOGENESIS; TESTIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS; TISSUE LEVEL; VITAMIN K DEFICIENCY; VITAMIN SUPPLEMENTATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; CARBOXY-LYASES; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DOWN-REGULATION; FARNESYLTRANSTRANSFERASE; HYDROXYMETHYLGLUTARYL COA REDUCTASES; INTRAMOLECULAR TRANSFERASES; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; TESTIS; TESTOSTERONE; VITAMIN K; VITAMIN K DEFICIENCY;

EID: 33748914544     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2006.05.008     Document Type: Article

References (43)

1. Suttie J.W. Synthesis of vitamin K-dependent proteins. FASEB J. 7 (1993) 445-452
2. Wu S.M., Stanley T.B., Mutucumarana V.P., and Stafford D.W. Characterization of the γ-glutamyl carboxylase. Thromb. Haemostasis 78 (1997) 599-604
3. Yamamoto R., Komai M., Kojima K., Furukawa Y., and Kimura S. Menaquinone-4 accumulation in various tissues after an oral administration of phylloquinone in Wistar rats. J. Nutr. Sci. Vitaminol. (Tokyo) 43 (1997) 133-143
4. Ronden J.E., Thijssen H.H., and Vermeer C. Tissue distribution of K-vitamers under different nutritional regimens in the rat. Biochim. Biophys. Acta 1379 (1998) 16-22
5. Huber A.M., Davidson K.W., O'Brien-Morse M.E., and Sadowski J.A. Tissue phylloquinone and menaquinones in rats are affected by age and gender. J. Nutr. 129 (1999) 1039-1044
6. Akiyama Y., Hara K., Tajima T., Murota S., and Morita I. Effect of vitamin K2 (menatetrenone) on osteoclast-like cell formation in mouse bone marrow cultures. Eur. J. Pharmacol. 263 (1994) 181-185
7. Kawata T., Zernik J.H., Fujita T., Tokimasa C., and Tanne K. Mechanism in inhibitory effects of vitamin K2 on osteoclastic bone resorption: in vivo study in osteopetrotic (op/op) mice. J. Nutr. Sci. Vitaminol. (Tokyo) 45 (1999) 501-507
8. 2 inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures. Bone 27 (2000) 769-776
9. Koshihara Y., Hoshi K., Okawara R., Ishibashi H., and Yamamoto S. Vitamin K stimulates osteoblastogenesis and inhibits osteoclastogenesis in human bone marrow cell culture. J. Endocrinol. 176 (2003) 339-348
10. Taira H., Fujikawa Y., Kudo O., Itonaga I., and Torisu T. Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors. Calcif. Tissue Int. 73 (2003) 78-85
11. Hiruma Y., Nakahama K., Fujita H., and Morita I. Vitamin K2 and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner. Biochem. Biophys. Res. Commun. 314 (2004) 24-30
12. Kameda T., Miyazawa K., Mori Y., Yuasa T., Shiokawa M., Nakamaru Y., Mano H., Hakeda Y., Kameda A., and Kumegawa M. Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis. Biochem. Biophys. Res. Commun. 220 (1996) 515-519
13. Yaguchi M., Miyazawa K., Otawa M., Katagiri T., Nishimaki J., Uchida Y., Iwase O., Gotoh A., Kawanishi Y., and Toyama K. Vitamin K2 selectively induces apoptosis of blastic cells in myelodysplastic syndrome: flow cytometric detection of apoptotic cells using APO2.7 monoclonal antibody. Leukemia 12 (1998) 1392-1397
14. Miyazawa K., Yaguchi M., Funato K., Gotoh A., Kawanishi Y., Nishizawa Y., You A., and Ohyashiki K. Apoptosis/differentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cells. Leukemia 15 (2001) 1111-1117
15. 2 selectively induced apoptosis in ovarian TYK-nu and pancreatic MIA PaCa-2 cells out of eight solid tumor cell lines through a mechanism different from geranylgeraniol. J. Cancer Res. Clin. Oncol. 129 (2003) 1-11
16. Yoshida T., Miyazawa K., Kasuga I., Yokoyama T., Minemura K., Ustumi K., Aoshima M., and Ohyashiki K. Apoptosis induction of vitamin K2 in lung carcinoma cell lines: the possibility of vitamin K2 therapy for lung cancer. Int. J. Oncol. 23 (2003) 627-632
17. Urayama S., Kawakami A., Nakashima T., Tsuboi M., Yamasaki S., Hida A., Ichinose Y., Nakamura H., Ejima E., Aoyagi T., Nakamura T., Migita K., Kawabe Y., and Eguchi K. Effect of vitamin K2 on osteoblast apoptosis: vitamin K2 inhibits apoptotic cell death of human osteoblasts induced by Fas, proteasome inhibitor, etoposide, and staurosporine. J. Lab. Clin. Med. 136 (2000) 181-193
18. Li J., Lin J.C., Wang H., Peterson J.W., Furie B.C., Furie B., Booth S.L., Volpe J.J., and Rosenberg P.A. Novel role of vitamin K in preventing oxidative injury to developing oligodendrocytes and neurons. J. Neurosci. 23 (2003) 5816-5826
19. 2 regulation of bone homeostasis is mediated by the steroid and xonobiotic receptor, SXR. J. Biol. Chem. 278 (2003) 43919-43927
20. Otsuka M., Kato N., Shao R.X., Hoshida Y., Ijichi H., Koike Y., Taniguchi H., Moriyama M., Shiratori Y., Kawabe T., and Omata M. Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation. Hepatology 40 (2004) 243-251
21. Billeter M., and Martius C. About the conversion of phylloquinone (vitamin K1) in to vitamin K2(20) in animal tissue. Biochem. Z. 333 (1960) 430-439
22. Kimura S., Satoh H., and Komai M. The roles of intestinal flora and intestinal function on vitamin K metabolism. J. Nutr. Sci. Vitaminol. (Tokyo) Suppl. (1992) 425-428
23. Will B.H., Usui Y., and Suttie J.W. Comparative metabolism and requirement of vitamin K in chicks and rats. J. Nutr. 122 (1992) 2354-2360
24. Thijssen H.H., and Drittij-Reijnders M.J. Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. Br. J. Nutr. 72 (1994) 415-425
25. Thijssen H.H., Drittij-Reijnders M.J., and Fischer M.A. Phylloquinone and menaquinone-4 distribution in rats: synthesis rather than uptake determines menaquinone-4 organ concentrations. J. Nutr. 126 (1996) 537-543
26. Ronden J.E., Drittij-Reijunders M.J., Vermeer C., and Thijssen H.H. Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat. Biochim. Biophys. Acta 1379 (1998) 69-75
27. Davidson R.T., Foley A.L., Engelke J.A., and Suttie J.W. Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria. J. Nutr. 128 (1998) 220-223
28. Thijssen H.H., Drittij H.J., Vermeer C., and Schoffelen E. Menaquinone-4 in breast milk is derived from dietary phylloquinone. Br. J. Nutr. 87 (2002) 219-226
29. Maurer-Stroh S., Washietl S., and Eisenhaber F. Protein prenyltransferases. Genome Biol. 4 (2003) 212
30. Lau A.S., and Mruk D.D. Rab8B GTPase and junction dynamics in the testis. Endocrinology 144 (2003) 1549-1563
31. Parker KL., Ikeda Y., and Luo X. The roles of steroidogenic factor-1 in reproductive function. Steroids 61 (1996) 161-165
32. Luo X., Ikeda Y., Lala D., Rice D., Wong M., and Parker KL. Steroidogenic factor 1 (SF-1) is essential for endocrine development and function. J. Steroid Biochem. Mol. Biol. 69 (1999) 13-18
33. Jeyasuria P., Ikeda Y., Jamin S.P., Zhao L., De Rooij D.G., Themmen A.P., Behringer R.R., and Parker K.L. Cell-specific knockout of steroidogenic factor 1 reveals its essential roles in gonadal function. Mol. Endocrinol. 18 (2004) 1610-1619
34. Hong C.Y., Park J.H., Ahn R.S., Im S.Y., Choi H.S., Soh J., Mellon S.H., and Lee K. Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha. Mol. Cell. Biol. 24 (2004) 2593-2604
35. Reddi K., Henderson B., Meghji S., Wilson M., Poole S., Hopper C., Harris M., and Hodges S.J. Interleukin 6 production by lipopolysaccharide-stimulated human fibroblasts is potently inhibited by naphthoquinone (vitamin K) compounds. Cytokine 7 (1995) 287-290
36. Ohsaki Y., Shirakawa H., Hiwatashi K., Furukawa Y., Mizutani T., and Komai M. Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat. Biosci. Biotechnol. Biochem. 70 (2006) 926-932
37. Anderson R.G. Joe Goldstein and Mike Brown: from cholesterol homeostasis to new paradigms in membrane biology. Trends Cell Biol. 13 (2003) 534-539
38. Weber L.W., Boll M., and Stampfl A. Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins. World J. Gastroenterol. 10 (2004) 3081-3087
39. Finkelstein J.S., Klibanski A., Neer R.M., Greenspan S.L., Rosenthal D.I., and Crowley Jr. W.F. Osteoporosis in men with idiopathic hypogonadotropic hypogonadism. Ann. Intern. Med. 106 (1987) 354-361
40. Alexandre C. Androgens and bone metabolism. Jt Bone Spine 72 (2005) 202-206
41. Binkley N.C., Krueger D.C., Engelke J.A., Foley A.L., and Suttie J.W. Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults. Am. J. Clin. Nutr. 72 (2000) 1523-1528
42. Otsuka M., Kato N., Ichimura T., Abe S., Tanaka Y., Taniguchi H., Hoshida Y., Moriyama M., Wang Y., Shao R.-X., Narayan D., Muroyama R., Kanai F., Kawabe T., Isobe T., and Omata M. Vitamin K2 binds 17β-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism. Life Sci. 76 (2005) 2473-2482
43. Mindnich R., Möller G., and Adamski J. The role of 17 beta-hydroxysteroid dehydrogenases. Mol. Cell. Endocrinol. 218 (2004) 7-20