Does central nitric oxide elicit pulmonary hypertension in conscious rats?

Respiratory Physiology and Neurobiology

Volumn 153, Issue 3, 2006, Pages 250-260

  Schwenke, Daryl O ^a   Pearson, James T ^b   Mori, Hidezo ^a   Shirai, Mikiyasu ^c  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b MONASH UNIVERSITY   (Australia)

^c HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

Chronic hypoxia; Nitric oxide; Pulmonary vasoconstriction; Sympathetic nervous system

Indexed keywords

ISOPRENALINE; LINSIDOMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; LUNG ARTERY PRESSURE; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; SYMPATHETIC TONE;

ADRENERGIC BETA-AGONISTS; ANALYSIS OF VARIANCE; ANIMALS; ANOXIA; BLOOD PRESSURE; ENZYME INHIBITORS; HEART RATE; HYPERTENSION; INFUSION PUMPS, IMPLANTABLE; INJECTIONS, INTRAVENTRICULAR; ISOPROTERENOL; MALE; MOLSIDOMINE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; TELEMETRY; TIME FACTORS; WAKEFULNESS;

EID: 33748803378     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2005.12.002     Document Type: Article

References (40)

1. Bansinath M., Arbabha B., Turndorf H., and Garg U.C. Chronic administration of a nitric oxide synthase inhibitor, N-nitro-l-arginine, and drug-induced increase in cerebellar cyclic GMP in vivo. Neurochem. Res. 18 10 (1993) 1063-1066
2. Barbera J.A., Peinado V.I., and Santos S. Pulmonary hypertension in COPD: old and new concepts. Monaldi Arch. Chest Dis. 55 6 (2000) 445-449
3. Bredt D.S., Hwang P.M., and Snyder S.H. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347 6295 (1990) 768-770
4. Bunag R.D. Validation in awake rats of a tail-cuff method for measuring systolic pressure. J. Appl. Physiol. 34 (1973) 279-282
5. Cabrera C.L., Bealer S.L., and Bohr D.F. Central depressor action of nitric oxide is deficient in genetic hypertension. Am. J. Hypertens. 9 3 (1996) 237-241
6. Cornwell T.L., Arnold E., Boerth N.J., and Lincoln T.M. Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am. J. Physiol. (Cell Physiol.) 267 5 Pt 1 (1994) C1405-C1413
7. Dwyer M.A., Bredt D.S., and Snyder S.H. Nitric oxide synthase: irreversible inhibition by l-NG-nitroarginine in brain in vitro and in vivo. Biochem. Biophys. Res. Commun. 176 3 (1991) 1136-1141
8. Fike C.D., Kaplowitz M.R., Thomas C.J., and Nelin L.D. Chronic hypoxia decreases nitric oxide production and endothelial nitric oxide synthase in newborn pig lungs. Am. J. Physiol. (Lung Cell Mol. Physiol.) 274 4 Pt 1 (1998) L517-L526
9. Fried R., and Reid L.M. The effect of isoproterenol on the development and recovery of hypoxic pulmonary hypertension. A structural and hemodynamic study. Am. J. Pathol. 121 1 (1985) 102-111
10. Gao L., Wang W., Li Y.L., Schultz H.D., Liu D., Cornish K.G., and Zucker I.H. Superoxide mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase. Circ. Res. 95 9 (2004) 937-944
11. Garthwaite J., and Boulton C.L. Nitric oxide signaling in the central nervous system. Annu. Rev. Physiol. 57 (1995) 683-706
12. Hampl V., and Herget J. Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension. Physiol. Rev. 80 4 (2000) 1337-1372
13. Huang K.L., Wu C.P., Kang B.H., and Lin Y.C. Chronic hypoxia attenuates nitric oxide-dependent hemodynamic responses to acute hypoxia. J. Biomed. Sci. 9 3 (2002) 206-212
14. Jimbo M., Suzuki H., Ichikawa M., Kumagai K., Nishizawa M., and Saruta T. Role of nitric oxide in regulation of baroreceptor reflex. J. Auton. Nerv. Syst. 50 2 (1994) 209-219
15. Kagiyama S., Tsuchihashi T., Abe I., Matsumura K., and Fujishima M. Central infusion of l-arginine or superoxide dismutase does not alter arterial pressure in SHR. Hypertens. Res. 23 4 (2000) 339-343
16. Le Cras T.D., and McMurtry I.F. Nitric oxide production in the hypoxic lung. Am. J. Physiol. (Lung Cell Mol. Physiol.) 280 4 (2001) L575-L582
17. Matsumura K., Abe I., Tsuchihashi T., and Fujishima M. Central nitric oxide attenuates the baroreceptor reflex in conscious rabbits. Am. J. Physiol. (Reg. Int. Comp. Physiol.) 274 4 Pt 2 (1998) R1142-R1149
18. Matsumura K., Tsuchihashi T., Kagiyama S., Abe I., and Fujishima M. Role of nitric oxide in the nucleus of the solitary tract of rats. Brain Res. 798 1-2 (1998) 232-238
19. McMurtry I.F., Petrun M.D., and Reeves J.T. Lungs from chronically hypoxic rats have decreased pressure response to acute hypoxia. Am. J. Physiol. (Heart Circ. Physiol.) 235 1 (1978) H104-H109
20. Megson I.L., and Webb D.J. Nitric oxide donor drugs: current status and future trends. Expert Opin. Investig. Drugs 11 5 (2002) 587-601
21. Morrison S.F. Differential control of sympathetic outflow. Am. J. Physiol. (Reg. Int. Comp. Physiol.) 281 (2001) R683-R698
22. Nishimura M., Takahashi H., Nanbu A., Sakamoto M., and Yoshimura M. Cardiovascular regulation by l-arginine in the brain of rats: role of the brain rennin-angiotensin system and nitric oxide. Am. J. Hypertens. 10 4 Pt 1 (1997) 389-396
23. Nurminen M.L., and Vapaatalo H. Effect of intracerebroventricular and intravenous administration of nitric oxide donors on blood pressure and heart rate in anaesthetized rats. Br. J. Pharmacol. 119 7 (1996) 1422-1426
24. Ohta A., Takagi H., Matsui T., Hamai Y., Iida S., and Esumi H. Localization of nitric oxide synthase-immunoreactive neurons in the solitary nucleus and ventrolateral medulla oblongata of the rat: their relation to catecholaminergic neurons. Neurosci. Lett. 158 1 (1993) 33-35
25. Patel K.P., Li Y.F., and Hirooka Y. Role of nitric oxide in central sympathetic outflow. Exp. Biol. Med. 226 9 (2001) 814-824
26. Priest R.M., Roberts T.P., Leach R.M., and Ward J.P. Membrane potential-dependent and -independent vasodilation in small pulmonary arteries from chronically hypoxic rats. J. Pharmacol. Exp. Ther. 285 (1998) 975-982
27. Qadri F., Carretero O.A., and Scicli A.G. Centrally produced neuronal nitric oxide in the control of baroreceptor reflex sensitivity and blood pressure in normotensive and spontaneously hypertensive rats. Jpn. J. Physiol. 81 3 (1999) 279-285
28. Sakuma I., Togashi H., Yoshioka M., Saito H., Yanagida M., Tamura M., Kobayashi T., Yasuda H., Gross S.S., and Levi R. NG-methyl-l-arginine, an inhibitor of l-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone?. Circ. Res. 70 3 (1992) 607-611
29. Sato J., Nair K., Hiddinga J., Eberhardt N.L., Fitzpatrick L.A., Katusic Z.S., and O'Brien T. eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis. Cardiovasc. Res. 47 4 (2000) 697-706
30. Schwenke D.O., Pearson J.T., Tsuchimochi H., Mori H., and Shirai M. Exogenous nitric oxide centrally enhances pulmonary reactivity in the normal and hypertensive rat. Clin. Exp. Pharmacol. Physiol. 32 (2005) 952-959
31. Shapoval L.N., Sagach V.F., and Pobegailo L.S. Nitric oxide influences ventrolateral medullary mechanisms of vasomotor control in the cat. Neurosci. Lett. 132 1 (1991) 47-50
32. Shirai M., Matsukawa K., Nishiura N., Kawaguchi A.T., and Ninomiya I. Changes in efferent pulmonary sympathetic nerve activity during systemic hypoxia in anesthetized cats. Am. J. Physiol. (Reg. Int. Comp. Physiol.) 269 6 Pt 2 (1995) R1404-R1409
33. Shirai M., Shindo T., and Ninomiya I. beta-Adrenergic mechanisms attenuated hypoxic pulmonary vasoconstriction during systemic hypoxia in cats. Am. J. Physiol. (Heart Circ. Physiol.) 266 5 Pt 2 (1994) H1777-H1785
34. Stopper H., Moller M., Bommel H.M., and Schmidt H.H. Cytotoxic versus genotoxic effects of nitric oxide (NO). Toxicol. Lett. 106 1 (1999) 59-67
35. Togashi H., Sakuma I., Yoshioka M., Kobayashi T., Yasuda H., Kitabatake A., Saito H., Gross S.S., and Levi R. A central nervous system action of nitric oxide in blood pressure regulation. J. Pharmacol. Exp. Ther. 262 1 (1992) 343-347
36. Voelkel N.F., and Tuder R.M. Hypoxia-induced pulmonary vascular remodeling: a model for what human disease?. J. Clin. Invest. 106 6 (2000) 733-738
37. Wada Y., Matsuoka H., Okuda S., and Imaizumi T. Chronic inhibition of nitric oxide in central nervous system does not cause hypertension. Hypertens. Res. 21 2 (1998) 97-101
38. Weissmann N., Nollen M., Gerigk B., Ardeschir Ghofrani H., Schermuly R.T., Gunther A., Quanz K., Fink L., Hanze J., Rose F., Seeger W., and Grimminger F. Downregulation of hypoxic vasoconstriction by chronic hypoxia in rabbits: effects of nitric oxide. Am. J. Physiol. (Heart Circ. Physiol.) 284 3 (2003) H931-H938
39. Zanzinger J., Czachurski J., and Seller H. Inhibition of basal and reflex-mediated sympathetic activity in the RVLM by nitric oxide. Am. J. Physiol. (Reg. Int. Comp. Physiol.) 268 4 Pt 2 (1995) R958-R962
40. Zanzinger J., Czachurski J., and Seller H. Nitric oxide in the ventrolateral medulla regulates sympathetic responses to systemic hypoxia in pigs. Am. J. Physiol. (Reg. Int. Comp. Physiol.) 275 1 Pt 2 (1998) R33-R39