Central infusion of L-arginine or superoxide dismutase does not alter arterial pressure in SHR

Hypertension Research

Volumn 23, Issue 4, 2000, Pages 339-343

  Kagiyama, Shuntaro ^a   Tsuchihashi, Takuya ^a   Abe, Isao ^a   Matsumura, Kiyoshi ^a   Fujishima, Masatoshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Brain; Nitric oxide; Rostral ventrolateral medulla; Superoxide; Tempol

Indexed keywords

ARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE INHIBITOR; SUPEROXIDE DISMUTASE; TEMPOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; LATERAL BRAIN VENTRICLE; MALE; NONHUMAN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0033949053     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.23.339     Document Type: Article

References (28)

1. G-Methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo: a role for nitric oxide in the central regulation of sympathetic tone? Circ Res 1992; 70: 607-611.
2. Togashi H, Sakuma I, Yoshioka M, et al: A central nervous system action of nitric oxide in blood pressure regulation. J Pharmacol Exp Ther 1992; 262: 343-347.
3. Spyer KM: Central nervous mechanisms contributing to cardiovascular control. J Physiol 1994; 474: 1-19.
4. Shapoval LN, Sagach VF, Pobegailo LS: Nitric oxide influences ventrolateral medullary mechanisms of vasomotor control in the cat. Neurosci Lett 1991; 132: 47-50.
5. Zanzinger J, Czachurski J, Seller H: Inhibition of basal and reflex-mediated sympathetic activity in the RVLM by nitric oxide. Am J Physiol 1995; 268: R958-R962.
6. Kagiyama S, Tsuchihashi T, Abe I, Fujishima M: Cardiovascular effects of nitric oxide in the rostral ventrolateral medulla of rats. Brain Res 1997; 757: 155-158.
7. Hirooka Y, Poison JW, Dampney RAL: Pressor and sympathoexcitatory effects of nitric oxide in the rostral ventrolateral medulla. J Hypertens 1996; 14: 1317-1324.
8. Cabrera CL, Bealer SL, Bohr DF: Central depressor action of nitric oxide is deficient in genetic hypertension. Am J Hypertens 1996; 9: 237-241.
9. Kagiyama S, Tsuchihashi T, Abe I, Fujishima M: Enhanced depressor response to nitric oxide in the rostral ventrolateral medulla of spontaneously hypertensive rats. Hypertension 1998; 31: 1030-1034.
10. Chen PY, Sanders PW: L-Arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats. J Clin Invest 1991; 88: 1559-1567.
11. Kristek F: Long-term administration of L-arginine did not influence blood pressure, heart rate, cardiac hypertrophy or arterial wall thickness of spontaneously hypertensive rats. Exp Physiol 1998; 83: 595-603.
12. Matsuoka H, Nakata M, Kohno K, et al: Chronic L-arginine administration attenuates cardiac hypertrophy in spontaneously hypertensive rats. Hypertension 1996; 27: 14-18.
13. Ono H, Ono Y, Frohlich ED: L-Arginine reverses severe nephrosclerosis in aged spontaneously hypertensive rats. J Hypertens 1999; 17: 121-128.
14. Suzuki H, Swei A, Zweifach BW, Schmid-Schönbein GW: In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats: hydroethidine microfluorography. Hypertension 1995; 25: 1083-1089.
15. Schnackenberg CG, Welch WJ, Wilcox CS: Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide. Hypertension 1998; 32: 59-64.
16. Nabika T, Nara Y, Ikeda K, Endo J, Yamori Y: Genetic heterogeneity of the spontaneously hypertensive rat. Hypertension 1991; 18: 12-16.
17. Paxinos G, Watson C (ed): The Rat Brain in Stereotaxic Coordinates. 2nd ed. New York, Academic Press, 1986.
18. Liu Y, Tsuchihashi T, Kagiyama S, Matsumura K, Abe I, Fujishima M: Central and peripheral mechanisms involved in hypertension induced by chronic inhibition of nitric oxide synthase in rats. J Hypertens 1998; 16: 1165-1173.
19. Kagiyama S, Tsuchihashi T, Abe I, Fujishima M: Pressor effect of nitric oxide in caudal ventrolateral medulla of rats. Fundam Clin Pharmacol 1997; 11 (Suppl 1): 111s-113s.
20. Matsumura K, Tsuchihashi T, Kagiyama S, Abe I, Fujishima M: Role of nitric oxide in the nucleus of the solitary tract of rats. Brain Res 1998; 798: 232-238.
21. Forte P, Copland M, Smith LM, Milne E, Sutherland J, Benjamin N: Basal nitric oxide synthesis in essential hypertension. Lancet 1997; 349: 837-842.
22. Turner SW, Wen C, Li M, Whitworth JA: L-Arginine prevents corticotropin-induced increase in blood pressure in the rats. Hypertension 1996; 27: 184-189.
23. Kerr S, Brosnan J, McIntyre M, Reid JL, Dominiczak AF, Hamilton CA: Superoxide anion production is increased in a model of genetic hypertension; role of the endothelium. Hypertension 1999; 33: 1353-1358.
24. Jackson TS, Xu A, Vita JA, Keaney JF Jr: Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res 1998; 83: 916-922.
25. 2α. Hypertension 1999; 33 (part II): 424-428.
26. Akaike T, Yoshida M, Miyamoto Y, et al: Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 1993; 32: 827-832.
27. MacKenzie A, Martin W: Loss of endothelium-derived nitric oxide in rabbit aorta by oxidant stress: restoration by superoxide dismutase mimetics. Br J Pharmacol 1998; 124: 719-728.
28. Wada Y, Matsuoka H, Okuda S, Imaizumi T: Chronic inhibition of nitric oxide in central nervous system does not cause hypertension. Hypertens Res 1998; 21: 97-101.