Vaccinia Virus Complement Control Protein Modulates Inflammation Following Spinal Cord Injury

Annals of the New York Academy of Sciences

Volumn 1010, Issue , 2003, Pages 534-539

  Reynolds, D N ^a   Smith, S A ^a   Zhang, Y P ^a   Lahiri, D K ^b   Morassutti, D J ^a   Shields, C B ^a   Kotwal, G J ^a,c  

^a University of Louisville School of Medicine   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Inflammation; Spinal cord injury; Vaccinia virus complement control protein

Indexed keywords

COMPLEMENT CONTROL PROTEIN; COMPLEMENT INHIBITOR; MYELOPEROXIDASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; COMPLEMENT INHIBITION; CONFERENCE PAPER; CONTROLLED STUDY; CONTUSION; DRUG DIFFUSION; DRUG EFFECT; EXPERIMENTAL MODEL; FEMALE; IMMUNOMODULATION; MYELITIS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; RAT; SPINAL CORD INJURY; STAINING; VACCINIA VIRUS;

ANIMALIA; VACCINIA VIRUS; RATTUS;

EID: 1342284259     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1299.099     Document Type: Conference Paper

References (6)

1. CARLSON, S.L., M.E. PARRISH, J.E. SPRINGER, et al. 1998. Acute inflammatory response in spinal cord following impact injury. Exp. Neurol. 151: 77-88.
2. KOTWAL, G.J. & B. Moss. 1988. Vaccinia virus encodes a secretory polypeptide structurally related to complement control proteins. Nature 335: 176-178.
3. REYNOLDS, D.N., K.L. KEELING, R. MOLESTINA, et al. 2000. Heparin binding activity of vaccinia virus complement control protein confers additional properties of uptake by mast cells and attachment to endothelial cells. Advances in Animal Virology. S. Jamee, Ed.: 337-342. Oxford and IBH. New York.
4. MAGNUSON, D.S., T.C. TRINDER, Y.P. ZHANG, et al. 1999. Comparing defects following excitotoxic and contusion injuries in the thoracic and lumbar spinal cord of the adult rat. Exp. Neurol. 156: 191-204.
5. KEELING, K.L., R.R. HICKS, J. MAHESH, et al. 2000. Local neutrophil influx following lateral fluid-percussion brain injury in rats is associated with accumulation of complement activation fragments of the third component (C3) of the complement system. J. Neuroimmunol. 105: 20-30.
6. REBHUN, J. & J. BOTVIN. 1980. Complement elevation in spinal cord injury. Ann. Allergy 44: 287-288.