Effect of starvation on gene expression of regulatory enzymes of glycolysis/gluconeogenesis in genetically obese (fa/fa) Zucker rats

International Journal of Obesity

Volumn 22, Issue 7, 1998, Pages 667-672

  Perez J X ^a   Manzano, A ^a   Tauler, A ^a   Battrons, R ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Gene expression; Gluconeogenesis; Glycolysis; Obese; Starvation

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; ENZYME; FRUCTOSE 2,6 BISPHOSPHATE; FRUCTOSE BISPHOSPHATASE; GLUCOKINASE; GLYCOLYTIC ENZYME; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PYRUVATE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GLUCONEOGENESIS; GLYCOLYSIS; HYPERINSULINEMIA; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; STARVATION;

ANIMALIA; RODENTIA;

EID: 0031809151     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800645     Document Type: Article

References (49)

1. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CJ, Hess JF. Leptin receptor missense mutation in the fatty Zucker rats. Nat Genet 1996; 13: 18-19.
2. Truett G, Bahary N, Friedman JM, Leibel RL. Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db). Proc Natl Acad Sci USA 1991; 88: 7806-7809.
3. Chua SC, Chung WK, Wu-Peng S, Zhang Y, Liu S, Tartaglia L, Leibel RL. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (Leptin) receptor. Science 1996; 271: 994-996.
4. Spiegelman BM, Flier JS. Adipogenesis and Obesity: Rounding out of the Big Picture. Cell 1996; 87: 377-389.
5. Bray GA. The Zucker-fatty rat. Fed Proc 1977; 36: 148-153.
6. Freedman MR, Horwitz BA, Stern JS. Effect of adrenalectomy and glucocorticoid replacement on development of obesity. Am J Physiol 1986; 250: R595-R607.
7. Hers HG, Hue L. Gluconeogenesis and related aspects of glycolysis. Ann Rev Biochem 1983; 52: 617-653.
8. Pilkis SJ, Claus TH, Kurland TH, Lange AJ, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme. Annu Rev Biochem 1995; 64: 799-835.
9. Van Schaftingen E. Fructose 2,6-bisphosphate. Adv Enzymol 1987; 59: 315-395.
10. Pilkis SJ, El-Maghrabi MR, Claus TH. Fructose-2,6-bisphos-phate in control of hepatic gluconcogenesis. From metabolites to molecular genetics. Diabetes Care 1990; 13: 582-599.
11. Hue L, Van de Werve G, Jeanrenaud B. Fructose-2,6-bisphosphate in livers of genetically obese rats. Biochem J 1983; 214: 1019-1022.
12. Van de Werve G, Jeanrenaud B. The onset of liver glycogen synthesis in fasted-refed lean and genetically obese (fa/fa) rats. Diahetologia 1987; 30: 169-174.
13. Sánchez-Gutiérrez JC, Sánchcz-Arias JA, Lechuga CG, Valle JC. Samper B, Feliu JE. Decreased responsiveness of basal gluconeogenesis to insulin action in hepatocytes isolated from genetically obese (fa/fa) Zucker rats. Endocrinology 1994; 134: 1868-1873.
14. Sánchez-Gutiérrez JC, Lechuga CG, Sánchez-Arias JA, Samper B, Feliu JE. Impairment of the modulation by glucose of hepatic gluconeogenesis in the genetically obese (fa/fa) Zucker rats. Endocrinology 1995; 136: 1877-1884 .
15. Auffray C, Rougeon F. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem 1980; 107: 303-314.
16. Sambrook J. Fristseh FF, Maniatis T. Molecular Cloning: A Lahoratory Manual (2nd edn). Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, 1989.
17. Colosia AD, Marker AJ, Lange AJ, El-Maghrabi MR, Granner DK, Tauler A, Pilkis J, Pilkis SJ. Induction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA by refeeding and insulin. J Biol Chem 1988; 263: 18669-18667.
18. El-Maghrabi MR, Pilkis J, Marker AJ, Colosia AD, D'Angelo G, Fraser BA, Pilkis SJ. cDNA sequence of rat liver fructose 1,6-bisphosphatase and evidence for down regulation of its mRNA by insulin. Proc Natl Acad Sci USA 1988; 85: 8430-8434.
19. Yoo-Warren H, Monohan JF, Short J, Short H, Bruzel A, Wynshaw-Boris A, Meisner HM, Samols D, Hanson RW. Isolation and characterization of the gene coding for cytosolic phosphoenolpyruvate carboxykinase (GTP) from the rat. Proc Natl Acad Sci USA 1983; 80: 3656-3660.
20. Andreone TL, Printz RL, Pilkis SJ, Magnuson MA, Granner DK. The amino acid sequence of rat liver glucokinase deduced from cloned cDNA. J Biol Chem 1989; 264: 363-369.
21. Lone YCh, Simon MP, Kahn A, Marie J. Complete nucleotide and deduced amino acid sequences of rat L-type pyruvate kinase. FEBS Lett 1986; 195: 97-100.
22. Gerlach WL, Bedbrook JR. Cloning and characterization of ribosomal RNA genes from wheat and barley. Nucleic Acid Res 1979; 7: 1869-1885.
23. Van Schaftingen E, Lederer B, Bartrons R, Hers HG. A kinetic study of phosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate. Eur J Biochem 1982; 129: 191-195.
24. Bartrons R, Hue L, Van Schaftingen E, Hers HG. Hormonal control of fructose 2,6-bisphosphate concentration in isolated rat hepatocytes. Biochem J 1983; 214: 829-837.
25. Feliu JE, Hue L, Hers HG. Regulation in vitro and in vivo of adenosine 3′:5′ monophosphate-dependent inactivation of rat-liver pyruvate kinase type L. Eur J Biochem 1977; 81: 609-617.
26. Davidson AL, Arion WJ. Factors underlying significant underestimations of glucokinase activity in crude liver extracts; physiological implications of higher cellular activity. Arch Biochem Biophys 1987; 253: 156-167.
27. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
28. Bumette WN. 'Western blotting': electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrilamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem 1981; 112: 195-203.
29. El-Maghrabi MR, Correia JJ, Heil PJ, Pate TM, Cobb C, Pilkis SJ. Tissue distribution, immunoreactivity and physical properties of 6-phosphofructo-2-kinase/fructose-2.6-bisphosphatase. Proc Natl Acad Sci USA 1986; 83: 5005-5009.
30. McCune SA, Durant PJ, Jenkins PA, Harris RA. Comparative studies on fatty acid synthesis, glycogen metabolism, and glueoneogenesis by hepatoeytes isolated from lean and obese Zucker rats. Metabolism 1981; 30: 1170-1178.
31. Terrettaz J, Jeanrenaud B. Contribution of glycerol and alanine to basal hepatic glucose production in the genetically obese (fa/fa) rat. Biochem J 1990; 270: 803-807.
32. Carb N, López-Soriano F, Argiles JM. Glucose handling by hepatoeytes from obese Zucker rats. Biosci Rep 1991; 11: 285-292.
33. Jeanrenaud B. Neuroendocrine and metabolic basis of type II diabetes as studied in animal models. Diabetes Metab Rev 1988; 4 603-614.
34. Bloxham DP, York DA. Metabolic flux through phosphofructokinase and fructose 1,6-diphosphatase and its relation to lipogenesis in genetically obese rats. Biochem Soc Transac 1976; 4: 989-993.
35. Martin RJ, Cahagan J. Serum hormone levels and tissue metabolism in pair-fed lean and obese Zucker rats, Horm Metab Res 1977; 9: 181-186.
36. Spydevold SO, Greenbaum AL, Baquer NZ, McLean P. Adaptative responses of enzymes of carbohydrate and lipid metabolism to dietary alteration in genetically obese Zucker rats (fa/fa). Eur J Biochem 1978; 89: 329-339.
37. van de Werve G, Jeanrenaud B. Synthase activation is not a prerequisite for glycogen synthesis in the starved liver. Am J Physiol 1984; 247: E271-E275.
38. Granner D, Pilkis SJ. The genes of hepatic glucose metabolism. J Biol Chem 1990; 265: 10173-10176.
39. Lemaigre FP, Rousseau GG. Transcriptional control of genes that regulate glycolysis and glueoneogenesis in adult liver. Biochem J 1994; 303: 1-14.
40. van de Werve G. Fasting enhances glycogen synthase activation in hepatoeytes from insulin-resistant genetically obese (fa/fa) rats. Biochem J 1990; 269: 789-794.
41. Terrettaz J, Jeanrenaud B. In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats. Endocrinology 1983; 112: 1346-1351.
42. Iynedjian PB, Jotterand D, Nouspikel T, Asfari M, Pilot PR. Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system. J Biol Chem 1989; 264: 21824-21829.
43. Noguchi T, Matsuda T, Tomari Y, Yamada K, Imai E, Wan Z, Ikeda H, Tanaka T, The regulation of gene expression by insulin is differentially impaired in the liver of the genetically obese-hyperglycemic wistar fatty rat. FEBS Lett 1993; 328: 145-148.
44. Vaulont S, Kahn A. Transcriptional control of metabolic regulation genes by carbohydrates. FASEB J 1994; 8: 28-35.
45. Marker AJ, Colosia AD, Tauler A, Solomon DH, Cayre Y, Lange AJ, El-Maghrabi MR, Pilkis SJ. Glucocorticoid regulation of hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression. J Biol Chem 1989; 264: 7000-7004.
46. Rosa JL, Ventura F, Tauler A, Bartrons R, Regulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression by glucagon. J Biol Chem 1993; 268: 22540-22545.
47. Crepin KM, Darville Ml, Hue L, Rousseau GG, Starvation or diabetes decreases the content but not the mRNA of 6-phospho-fructo-2-kinase in rat livers. FEBS Lett 1988; 227: 136-140.
48. Miralpeix M, Carballo E, Bartrons R, Crepin K, Hue L, Rousseau GG. Oral administration of vanadate to diabetic rats restores liver 6-phosphofructo-2-kinase content and mRNA. Diabetologia 1992; 35: 243-248.
49. Lemaigre FP, Lause P, Rousseau GG. Insulin inhibits gluco-corticoid-induced stimulation of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene transcription. FEBS Lett 1994; 340: 221-225.