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33748602216
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See refs 4d and 4j; ref 4k is also concerned with (pyrrol-2-yl)acetic acids synthesis, which however required several steps.
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Ten substrates (1a-j) were prepared as follows: to a solution of ethyl propiolate in THF was added BuLi at -78 °C, and the mixture was stirred at that temperature for 15 min. To this mixture was added enone at -78 °C followed by stirring at -78 - 0 °C for 4.5 h. After the usual workup, the alcohol product was purified by column chromatography and silylated in the usual way (TMS-Cl, imidazole, THF, 0 °C to rt, 0.5 h) to give 1, which was purified by column chromatography prior to use. The % yields of 1 depended on the structure of enones. For the experimental detail and spectroscopic data. see Supporting Information.
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26
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33748631114
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These sulfonamides are commercially available.
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27
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For discussion about stereocontrol of this kind, see ref 6.
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N1 process must wait for future studies.
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For discussion about the lower basicity of disiloxane, see ref 12 and references therein.
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