Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 9, 2000, Pages 2305-2309

  Silvestri, Romano ^a   Artico, Marino ^a   De Martino, Gabriella ^a   Novellino, Ettore ^b   Greco, Giovanni ^b   Lavecchia, Antonio ^b   Massa, Silvio ^c   Loi, Anna Giulia ^d   Doratiotto, Silvia ^d   La Colla, Paolo ^d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

^d Dipto di Biologia Sperimentale   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(1H BENZIMIDAZOL 5 YL)SULFONYL] 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 1 [(1H BENZOTRIAZOL 5 YL)SULFONYL] 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 1 [[2 OXO(3H) 1H BENZIMIDAZOL 5 YL]SULFONYL] 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; NEVIRAPINE; PYRROLE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; COMPUTER AIDED DESIGN; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; BENZIMIDAZOLES; CELL DIVISION; CELL SURVIVAL; COMPUTER-AIDED DESIGN; DRUG DESIGN; ENZYME INHIBITORS; HIV-1; INHIBITORY CONCENTRATION 50; PROLINE; RNA-DIRECTED DNA POLYMERASE; SULFONES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0033869197     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00144-9     Document Type: Article

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