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Volumn 24, Issue 2, 2006, Pages 56-61

Faster selective chemistry by microflow and continuous microwave synthesis

Author keywords

[No Author keywords available]

Indexed keywords


EID: 33748611603     PISSN: 0392839X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (16)

References (51)
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    • T. Schwalbe et al., Chimia, 56, p. 634 (2002)
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    • Schwalbe, T.1
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    • and literature referenced therein
    • C. Kappe, Angew. Chem., Int. Ed. 43, p. 6250 (2004) and literature referenced therein
    • (2004) Angew. Chem., Int. Ed. , vol.43 , pp. 6250
    • Kappe, C.1
  • 9
    • 33748602797 scopus 로고    scopus 로고
    • note
    • Enhanced mixing times result from dedicated efforts in designing microflow devices as passive mixing elements. A simple neighboring location of fluid laminae in a channel leads to mixing only by secondary effects that are slower than the herein described mixing effect.
  • 12
    • 16344394048 scopus 로고    scopus 로고
    • In a batch process, addition times often drive the total duration of a synthetic step and would be considered reaction time. In a continuous process the average reaction time can be more easily determined. Scientific comparisons of reaction times from such dosage dependent batch processes and continuous processes hardly make sense. Economic comparisons of course do. The reaction time in a continuously operated device is dispersed around the average computable reaction time in a manner depending on the device's design. Suffice it to say, there is a huge difference between the classic continuously stirred tank reactor (CSTR) and a well -designed microflow reactor system (K. Golbig et al., Chem. Eng. Com., 192(5), p. 620 (2005))
    • (2005) Chem. Eng. Com. , vol.192 , Issue.5 , pp. 620
    • Golbig, K.1
  • 13
    • 22244462172 scopus 로고    scopus 로고
    • and there are plenty of solutions between these and beyond the latter as in B. Yen et al., Chem. Int. Ed., 44, p. 5447 (2005).
    • (2005) Chem. Int. Ed. , vol.44 , pp. 5447
    • Yen, B.1
  • 14
    • 33748623259 scopus 로고    scopus 로고
    • note
    • It was noted, that some experiments using meso-scale tubes gave considerably lower yields and higher amounts of by-products, see reference 11.
  • 18
    • 33748617472 scopus 로고    scopus 로고
    • See reference 59 and 262 in reference 6
    • See reference 59 and 262 in reference 6,
  • 22
    • 33748628124 scopus 로고    scopus 로고
    • note
    • Aqueous medium, _T = 75 K, flow rate = 8.8 l/h, reactor volume 880 ml, from reference 34
  • 23
    • 33645412119 scopus 로고    scopus 로고
    • Overall isothermal reaction conduct in microwave has been accomplished: J. Jachuk et al., Green Chem., 8, p. 29 (2006)
    • (2006) Green Chem. , vol.8 , pp. 29
    • Jachuk, J.1
  • 24
    • 17844392839 scopus 로고    scopus 로고
    • and continues in this respect to reference 9
    • The perspective of this short review parallels a perspective used in: V. Hessel et al., Cur. Org. Chem., 9(8), p. 765 (2005) and continues in this respect to reference 9
    • (2005) Cur. Org. Chem. , vol.9 , Issue.8 , pp. 765
    • Hessel, V.1
  • 25
    • 33748599733 scopus 로고    scopus 로고
    • note
    • Significant pioneering achievements in investigating the breadth of microflow applicability were made in conjunction with electro osmotic flow propagation, (a means of actively controlling chemistry by itself), by Haswell, S., Watts, P., their collaboration partners and coworkers, see reference 2, 3 and literature cited therein.
  • 29
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    • http://www.cpc-net.com/reactions/CPC01001.html
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    • US Patent US 09/617,068, 2000 and Eur. Patent EP 1 174 184, 2001
    • T. Schwalbe et al., US Patent US 09/617,068, 2000 and Eur. Patent EP 1 174 184, 2001
    • Schwalbe, T.1
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    • J. Köhler et al., Chem. Eng. J., 101(1-3), p. 201 (2004)
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  • 43
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    • C. de Bellefon et al., Chimia, 56(11), p. 621 (2002)
    • (2002) Chimia , vol.56 , Issue.11 , pp. 621
    • De Bellefon, C.1
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    • H. Pennemann et al., AIChE J., 50(8), p. 1814 (2003)
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    • Pennemann, H.1
  • 51
    • 33748604453 scopus 로고    scopus 로고
    • note
    • The authors are indebted to the unknown referee for his fundamental recommendations on the article.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.