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and literature referenced therein
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Kappe, C.1
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9
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33748602797
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note
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Enhanced mixing times result from dedicated efforts in designing microflow devices as passive mixing elements. A simple neighboring location of fluid laminae in a channel leads to mixing only by secondary effects that are slower than the herein described mixing effect.
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11
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33645647400
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June 12-15, Gyeongju, Korea
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J. Kim et al., Proceedings of the 4th Asia-Pacific Chemical Engineering Symposium, APCRE05, June 12-15, 2005, Gyeongju, Korea, 441
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Kim, J.1
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12
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16344394048
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In a batch process, addition times often drive the total duration of a synthetic step and would be considered reaction time. In a continuous process the average reaction time can be more easily determined. Scientific comparisons of reaction times from such dosage dependent batch processes and continuous processes hardly make sense. Economic comparisons of course do. The reaction time in a continuously operated device is dispersed around the average computable reaction time in a manner depending on the device's design. Suffice it to say, there is a huge difference between the classic continuously stirred tank reactor (CSTR) and a well -designed microflow reactor system (K. Golbig et al., Chem. Eng. Com., 192(5), p. 620 (2005))
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and there are plenty of solutions between these and beyond the latter as in B. Yen et al., Chem. Int. Ed., 44, p. 5447 (2005).
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Yen, B.1
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14
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33748623259
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note
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It was noted, that some experiments using meso-scale tubes gave considerably lower yields and higher amounts of by-products, see reference 11.
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18
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33748617472
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See reference 59 and 262 in reference 6
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See reference 59 and 262 in reference 6,
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22
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33748628124
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note
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Aqueous medium, _T = 75 K, flow rate = 8.8 l/h, reactor volume 880 ml, from reference 34
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-
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23
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33645412119
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Overall isothermal reaction conduct in microwave has been accomplished: J. Jachuk et al., Green Chem., 8, p. 29 (2006)
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17844392839
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and continues in this respect to reference 9
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The perspective of this short review parallels a perspective used in: V. Hessel et al., Cur. Org. Chem., 9(8), p. 765 (2005) and continues in this respect to reference 9
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Hessel, V.1
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25
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33748599733
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note
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Significant pioneering achievements in investigating the breadth of microflow applicability were made in conjunction with electro osmotic flow propagation, (a means of actively controlling chemistry by itself), by Haswell, S., Watts, P., their collaboration partners and coworkers, see reference 2, 3 and literature cited therein.
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29
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33748620549
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http://www.cpc-net.com/reactions/CPC01001.html
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38
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33748589863
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The authors are indebted to the unknown referee for his fundamental recommendations on the article.
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