Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amlyoid β-protein in cerebrovascular smooth muscle cells

Journal of Neuroinflammation

Volumn 3, Issue , 2006, Pages

  Previti, Mary Lou ^a   Zhang, Weibing ^a   Van Nostrand, William E ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DEXAMETHASONE; GELATIN; GELATINASE A; IBUPROFEN; INDOMETACIN; INTERLEUKIN 6; NONSTEROID ANTIINFLAMMATORY AGENT;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD VESSEL WALL; BRAIN BLOOD VESSEL; BRAIN HEMORRHAGE; CELL CULTURE; CELL DEATH; CELL DEGENERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; INFLAMMATION; QUANTITATIVE ANALYSIS; RISK REDUCTION; SMOOTH MUSCLE FIBER; VASCULAR AMYLOIDOSIS; ZYMOGRAPHY;

EID: 33748589713     PISSN: 17422094     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-3-18     Document Type: Article

References (44)

1. Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
2. Golde TE: The Aβ hypothesis: leading us to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease. Brain Pathol 2005, 15:84-87.
3. Jellinger KA: Alzheimer's disease and cerebrovascuiar pathology: an update. J Neural Trasm 2002, 109:813-836.
4. Vinters HV, Farag ES: Amyloidosis of cerebral arteries. Adv Neurol 2003, 92:105-112.
5. Rensink AA, de Waal RM, Kremer B, Verbeek MM: Pathogenesis of cerebral amyloid angiopathy. Brain Res Brain Res Rev 2003, 43:207-223.
6. Kawai M, Kalaria RN, Cras P, Siediak SL, Velasco ME, Shelton ER, Chan HW, Greenberg BD, Perry G: Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease. Brain Res 1993, 623:142-146.
7. Wisniewski HM, Frackowiak J, Zoltowska A, Kim KS: Vascular β-amyloid in Alzheimer's disease angiopathy is produced by proliferating and degenerating smooth muscle cells. Amyloid 1994, 1:8-16.
8. Bailey TL, Rivara CB, Rocher AB, Hof PR: The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease. Neurol Res 2004, 26:573-578.
9. Attems J, Jellinger KA: Only cerebral capillary amyloid angiopathy correlates with Alzheimer pathology - a pilot study. Acta Neuropathol 2004, 107:83-90.
10. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS): Pathological correlates of late-onset dementia in a multicentre, community-bated population in England and Wales. Lancet 2001, 357:169-175.
11. Thai DR, Ghebremedhin E, Orantes M, Wiestler OD: Vascular pathology in Alzheimer's disease: Correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline. J Neuropath Exp Neurol 2003, 62:1287-1301.
12. Levy E, Carman MD, Fernandez-Madrid IJ, Power MD, Lieberburg I, van Duinen SG, Bots GTAM, Luyendijk W, Frangione B: Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990, 248:1124-1126.
13. Hendriks L, van Duijn CM, Cras P, Cruts M, Van Hul W, van Harskamp F, Warren A, McInnis MG, Antonarakis SE, Martin JJ, Hofman A, Van Broeckhoven C: Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet 1992, 1:218-221.
14. Tagliavini F, Rossi G, Padovani A, Magoni M, Andora G, Sgarzi M, Bizzi A, Savioardo M, Carella F, Morbin M, Giaccone G, Bugiani O: A new βPP mutation related to hereditary cerebral haemorrhage. Alzeimer's Reports 1999, 2:S28.
15. Grabowski TJ, Cho HS, Vonsattel JPG, Rebeck GW, Greenberg SM: Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neural 2001, 49:697-705.
16. van Duinen SG, Castano EM, Prelli F, Bots GTAM, Luyendijk W, Frangione B: Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer's disease. Proc Natl Acad Sci USA 1987, 84:5991-5994.
17. Wattendorff AR, Frangione B, Luyendijk W, Bots GTAM: Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): clinicopathological studies. J Neurol Neurosurg Psychiatry 1995, 59:699-705.
18. Maat-Schieman ML, van Duinen SG, Rozemuller AJ, Haan J, Roos RA: Association of vascular amyloid beta and cells of the mononuclear phagocyte system in hereditary cerebral hemorrhage with amyloidosis (Dutch) and Alzheimer disease. J Neuropathol Exp Neurol 1997, 56:273-84.
19. Maat-Schieman MLC, Yamaguchi H, Hegeman-Kleinn I, Welling-Graafland C, Natte R, Roos RAC, van Duinen SG: Glial reactions and the clearance of amyloid β protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. Acta Neuropathol 2004, 107:389-398.
20. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NP, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion M K, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T: Inflammation and Alzheimer's disease. Neurobiol Aging 2000, 21:383-421.
21. McGeer EG, McGeer PL: Inflammatory processes in Alzheimer's disease. Prog Neuro-Psychopharm Biol Psychiat 2003, 27:741-749.
22. Eng JA, Frosch MP, Choi K, Rebeck GW, Greenberg SM: Clinical manifestations of cerebral amyloid angiopathy-related inflammation. Ann Neurol 2004, 55:250-256.
23. Harkness KA, Coles A, Pohl U, Xuereb JH, Baron JC, Lennox GG: Rapidly reversible dementia in cerebral amyloid inflammatory vasculopathy. Eur J Neurol 2004, 11:59-62.
24. Oh U, Gupta R, Krakauer JW, Khandji AG, Chin SS, Elkind MSV: Reversible leukoencephalopathy associated with cerebral amyloid angiopathy. Neurology 2004, 62.494-497.
25. Hoshi K, Yoshida K, Nakamura A, Tada T, Tamaoka A, Ikeda S: Cessation of cerebral hemorrhage recurrence associated with corticosteroid treatment in a patient with cerebral amyloid angiopathy. Amyloid 2000, 7:284-288.
26. Van Nostrand WE, Wagner SL, Suzuki M, Choi BH, Farrow JS, Geddes JW, Cotman CW, Cunningham DD: Protease nexin-II, a potent antichymotrypsin, shows identity to the amyloid β-protein precursor. Nature 1989, 341:546-549.
27. Van Nostrand WE, Rozemuller AJM, Chung R, Cotman CW, Saporito-Irwin SM: Amyloid β-protein precursor in cultured leptomeningeal smooth muscle cells. Amyloid 1994, 1:1-7.
28. Davis J, Cribbs DH, Cotman CW, Van Nostrand WE: Pathogenic amyloid β-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells. Amyloid 1999, 6:157-164.
29. Johnstone M, Gearing AJH, Miller KM: A central role for astrocytes in the inflammatory response to β-amyloid: chemokines, cytokines, and reactive oxygen species are produced. J Neuroimmunol 1999, 93:182-193.
30. Rogers J, Lue LF: Microglial chemotaxis, activation, and phagocytosis of amyloid β-peptide as linked phenomena in Alzheimer's disease. Neurochem Intl 2001, 39:333-340.
31. Smits HA, Rijsmus A, Van Loon JH, Wat JWY, Verhoef J, Boven LA, Nottet HS: Aβ-induced chemokine production in primary human macrophages and astrocytes. J Neuroimmunol 2002, 127:160-168.
32. Moore AH, O'Banion MK: Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease. Adv Drug Delivery Rev 2002, 54:1627-1656.
33. Davis J, Van Nostrand WE: Enhanced pathologic properties of Dutch-type mutant amyloid β-protein. Proc Natl Acad Sci USA 1996, 93:2996-3000.
34. Van Nostrand WE, Melchor J, Ruffini L: Pathologic cell surface amyloid β-protein fibril assembly in cultured human cerebrovascular smooth muscle cells. J Neurochem 1997, 69:216-223.
35. Melchor JP, Van Nostrand WE: Fibrillar amyloid β-protein mediates the pathologic accumulation of its secreted precursor in human cerebrovascular smooth muscle cells. J Biol Chem 2000, 275:9782-9791.
36. Miao J, Xu F, Davis J, Otte-Holler I, Verbeek MM, Van Nostrand WE: Cerebral microvascular amyloid β protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid β precursor protein. Am J Pathol 2005, 167:505-515.
37. Mun-Bryce S, Lukes A, Wallace J, Lukes-Marx M, Rosenberg GA: Stromelysin-1 and gelatinase A are upregulated before TNF-α in LPS-stimulated neuroinflammation. Brain Res 2002, 933:42-49.
38. Rosenberg GA, Mun-Bryce S, Wesley M, Koenfeld M: Collagenase-induced intracerebral hemorrhage in rat. Stroke 1990, 21:801-807.
39. Rosenberg GA, Navratil BS: Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat. Neurology 1997, 48:921-926.
40. Frisch SM, Ruoslahti E: Integrins and anoikis. Curr Opin Cell Biol 1997, 9:701-706.
41. Jung SS, Zhang W, Van Nostrand WE: Pathogenic Aβ induces the expression and activation of matrix metalloproteinase-2 in human cerebrovascular smooth muscle cells. J Neurochem 2003, 85:1208-1215.
42. In't Veld BA, Launer LJ, Breteler MMB, Hofman A, Stricker BHC: Pharmacologic agents associated with a preventive effect on Alzheimer's disease: a review of the epidemiological evidence. Epidemiologic Rev 2002, 24:248-268.
43. Etminan M, Gill S, Samii A: Effect of non-steroidal anti-inflammatory drugs on the risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. Br Med J 2003, 327:128-132.
44. Aisen PS: The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease. Lancet Neurol 2002, 1:279-284.