Carbonic anhydrase inhibitors. N-Cyanomethylsulfonamides - A new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 21, Issue 4, 2006, Pages 477-481

  Winum, Jean Yves ^a   Cecchi, Alessandro ^b   Seridi, Achour ^a   Scozzafava, Andrea ^b   Montero, Jean Louis ^a   Supuran, Claudiu T ^b  

^a UNIV MONTPELLIER   (France)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

CA I; CA II; CA IX; Carbonic anhydrase; Inhibition; N cyanomethyl sulfonamides

Indexed keywords

AMINOACETONITRILE; BENZENE DERIVATIVE; BIS N CYANOMETHYL 1,3 BENZENEDISULFONAMIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; ISOENZYME; N CYANOMETHYL 4 BIPHENYLSULFONAMIDE; N CYANOMETHYL 4 BROMOPHENYLSULFONAMIDE; N CYANOMETHYL 4 CHLOROPHENYLSULFONAMIDE; N CYANOMETHYL 4 FLUOROPHENYLSULFONAMIDE; N CYANOMETHYL 4 IODOPHENYLSULFONAMIDE; N CYANOMETHYL 4 METHYLPHENYLSULFONAMIDE; N CYANOMETHYL 4 NAPHTHYLSULFONAMIDE; N CYANOMETHYL 4 NITROPHENYLSULFONAMIDE; N CYANOMETHYL 4 TERT BUTYLPHENYLSULFONAMIDE; N CYANOMETHYL PENTAFLUOROPHENYLSULFONAMIDE; N CYANOMETHYLSULFONAMIDE DERIVATIVE; NAPHTHALENE DERIVATIVE; ORGANOHALOGEN DERIVATIVE; SULFANILAMIDE; SULFONAMIDE; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CELL ANCHORAGE; CELL MEMBRANE; CHEMICAL REACTION; CONTROLLED STUDY; CYTOSOL; DRUG BINDING SITE; DRUG DESIGN; DRUG MECHANISM; ENZYME INHIBITION; INHIBITION KINETICS; PRIORITY JOURNAL; SUBSTITUTION REACTION;

CARBONIC ANHYDRASE INHIBITORS; CELL MEMBRANE; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; PROTEIN BINDING; PROTEIN ISOFORMS; SULFONAMIDES; ZINC;

EID: 33748498460     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360600642370     Document Type: Article

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