Adenovirus-mediated transfer of siRNA against Runx2/Cbfa1 inhibits the formation of heterotopic ossification in animal model

Biochemical and Biophysical Research Communications

Volumn 349, Issue 2, 2006, Pages 564-572

  Lin, Lin ^a   Chen, Lianxu ^a   Wang, Haijun ^a   Wei, Xuelei ^a   Fu, Xin ^a   Zhang, Jiying ^a   Ma, Kangtao ^b   Zhou, Chunyan ^b   Yu, Changlong ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Adenovirus; Gene therapy; Heterotopic ossification; Osteoblast; Runx2 Cbfa1; siRNA

Indexed keywords

ADENOVIRUS VECTOR; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 4; COLLAGEN TYPE 1; MESSENGER RNA; OSTEOCALCIN; OSTEOPONTIN; SIALOPROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RUNX2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEMINERALIZATION; BONE MATRIX; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE SILENCING; HETEROTOPIC OSSIFICATION; MALE; MAMMAL CELL; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; TECHNOLOGY; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DISEASE MODELS, ANIMAL; DNA PRIMERS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE THERAPY; GENETIC VECTORS; MICE; OSSIFICATION, HETEROTOPIC; OSTEOBLASTS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

ADENOVIRIDAE; ANIMALIA; MAMMALIA;

EID: 33748475848     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.08.089     Document Type: Article

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