Karyotypic characteristics of human uterine leiomyoma and myometrial cell lines following telomerase induction

Cancer Genetics and Cytogenetics

Volumn 170, Issue 1, 2006, Pages 71-75

  Varella Garcia, Marileila ^a   Chen, Lin ^a   Zheng, Xiaolin ^b   Yu, Linda ^b   Dixon, Darlene ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; CARCINOGENESIS; CELL CLONE; CELL IMMORTALIZATION; CELL STRUCTURE; CHROMOSOME 1P; CHROMOSOME 5Q; CHROMOSOME TRANSLOCATION 12; CHROMOSOME TRANSLOCATION 14; CONTROLLED STUDY; ENZYME INDUCTION; FEMALE; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; KARYOTYPE; MONOSOMY X; MYOMETRIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; TELOMERE; UTERUS MYOMA;

CELL LINE; ENZYME INDUCTION; FEMALE; HUMANS; KARYOTYPING; LEIOMYOMA; MYOMETRIUM; TELOMERASE; UTERINE NEOPLASMS;

EID: 33748474206     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2006.05.003     Document Type: Article

References (30)

1. de Lange T. Protection of mammalian telomeres. Oncogene 21 (2002) 532-540
2. Nakayama J., Tahara H., Tahara E., Saito M., Ito K., Nakamura H., Nakanishi T., Tahara E., Ide T., and Ishikawa F. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet 18 (1998) 65-68
3. Ulaner G.A., Hu J.F., Vu T.H., Giudice L.C., and Hoffman A.R. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res 58 (1998) 4168-4172
4. Nakamura T.M., Morin G.B., Chapman K.B., Weinrich S.L., Andrews W.H., Lingner J., Harley C.B., and Cech T.R. Telomerase catalytic subunit homologs from fission yeast and human. Science 277 (1997) 955-959
5. Bodnar A.G., Ouellette M., Frolkis M., Holt S.E., Chiu C.P., Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S., and Wright W.E. Extension of life-span by introduction of telomerase into normal human cells. Science 279 (1998) 349-352
6. Jiang X.R., Jimenez G., Chang E., Frolkis M., Kusler B., Sage M., Beeche M., Bodnar A.G., Wahl G.M., Tlsty T.D., and Chiu C.P. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet 21 (1999) 111-114
7. Morales C.P., Holt S.E., Ouellette M., Kaur K.J., Yan Y., Wilson K.S., White M.A., Wright W.E., and Shay J.W. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet 21 (1999) 115-118
8. Farwell D.G., Shera K.A., Koop J.I., Bonnet G.A., Matthews C.P., Reuther G.W., Coltrera M.D., McDougall J.K., and Klingelhutz A.J. Genetic and epigenetic changes in human epithelial cells immortalized by telomerase. Am J Pathol 156 (2000) 1537-1547
9. Yang J., Chang E., Cherry A.M., Bangs C.D., Oei Y., Bodnar A., Bronstein A., Chiu C.P., and Herron G.S. Human endothelial cell life extension by telomerase expression. J Biol Chem 274 (1999) 26141-26148
10. Xiaoxue Y., Zhongqiang C., Zhaoqing G., Gengting D., Qingjun M., and Shenwu W. Immortalization of human osteoblasts by transferring human telomerase reverse transcriptase gene. Biochem Biophys Res Commun 315 (2004) 643-651
11. Carney S.A., Tahara H., Swartz C.D., Risinger J.I., He H., Moore A.B., Haseman J.K., Barrett J.C., and Dixon D. Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristics. Lab Invest 82 (2002) 719-728
12. Lumsden M.A., and Wallace E.M. Clinical presentation of uterine fibroids. Baillieres Clin Obstet Gynaecol 12 (1998) 177-195
13. Moss N.S., and Benditt E.P. Human atherosclerotic plaque cells and leiomyoma cells: comparison of in vitro growth characteristics. Am J Pathol 78 (1975) 175-190
14. Cramer S.F., Robertson Jr. A.L., Ziats N.P., and Pearson O.H. Growth potential of human uterine leiomyomas: some in vitro observations and their implications. Obstet Gynecol 66 (1985) 36-41
15. Kops G.J., Weaver B.A., and Cleveland D.W. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 5 (2005) 773-785
16. Romanov S.R., Kozakiewicz B.K., Holst C.R., Stampfer M.R., Haupt L.M., and Tlsty T.D. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 409 (2001) 633-637
17. Honda T., Sadamori N., Oshimura M., Horikawa I., Omura H., Komatsu K., and Watanabe M. Spontaneous immortalization of cultured skin fibroblasts obtained from a high-dose atomic bomb survivor. Mutat Res 354 (1996) 15-26
18. Wei S., and Sedivy J.M. Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts. Cancer Res 59 (1999) 1539-1543
19. Mondello C., Chiesa M., Rebuzzini P., Zongaro S., Verri A., Colombo T., Giulotto E., D'Incalci M., Franceschi C., and Nuzzo F. Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals. Biochem Biophys Res Commun 308 (2003) 914-921
20. van Bokhoven A., Caires A., DiMAria M., Schulte A.P., Lucia M.S., Nordeen S.K., Miller G.J., and Varella-Garcia M. Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines. Prostate 57 (2003) 226-244
21. ISCN 2005: an international system for human cytogenetic nomenclature (2005). In: Shaffer L.G., and Tommerup N. (Eds) (2005), S. Karger, Basel
22. Harley C.B. Telomerase is not an oncogene. Oncogene 21 (2002) 494-502
23. Vaziri H., Squire J.A., Pandita T.K., Bradley G., Kuba R.M., Zhang H., Gulyas S., Hill R.P., Nolan G.P., and Benchimol S. Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts. Mol Cell Biol 19 (1999) 2373-2379
24. O'Hare M.J., Bond J., Clarke C., Takeuchi Y., Atherton A.J., Berry C., Moody J., Silver A.R., Davies D.C., Alsop A.E., Neville A.M., and Jat P.S. Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells. Proc Natl Acad Sci U S A 98 (2001) 646-651
25. Jester J.V., Huang J., Fisher S., Spiekerman J., Chang J.H., Wright W.E., and Shay J.W. Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts. Invest Ophthalmol Vis Sci 44 (2003) 1850-1858
26. Wise S.S., Elmore L.W., Holt S.E., Little J.E., Antonucci P.G., Bryant B.H., and Wise J.P. Telomerase-mediated lifespan extension of human bronchial cells does not affect hexavalent chromium-induced cytotoxicity or genotoxicity. Mol Cell Biochem 255 (2004) 103-111
27. Cui W., Aslam S., Fletcher J., Wylie D., Clinton M., and Clark A.J. Stabilization of telomere length and karyotypic stability are directly correlated with the level of hTERT gene expression in primary fibroblasts. J Biol Chem 277 (2002) 38531-38539
28. Hook E.B. Exclusion of chromosomal mosaicism: tables of 90%, 95% and 99% confidence limits and comments on use. Am J Hum Genet 29 (1977) 94-97
29. Sandberg A.A. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyoma. Cancer Genet Cytogenet 158 (2005) 1-26
30. Toouli C.D., Huschtscha L.I., Neumann A.A., Noble J.R., Colgin L.M., Hukku B., and Reddel R.R. Comparison of human mammary epithelial cells immortalized by simian virus 40 T-antigen or by the telomerase catalytic subunit. Oncogene 21 (2002) 128-139