GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: Upregulation in transgenic mice blocks spermatogenesis in pachytene

Biology of Reproduction

Volumn 65, Issue 6, 2001, Pages 1663-1671

  Kroft, T L ^a   Patterson, J ^a   Joon Won Yoon, ^a   Doglio, L ^a   Walterhouse, D O ^a   Iannaccone, P M ^a   Goldberg, E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Apoptosis; Developmental biology; Gene regulation; Signal transduction; Spermatogenesis; Testis

Indexed keywords

LACTATE DEHYDROGENASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; GERM LAYER; LEYDIG CELL; MALE; MICROTUBULE; MOUSE; NEWBORN; NONHUMAN; PACHYTENE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SERTOLI CELL; SIGNAL TRANSDUCTION; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; TRANSGENIC MOUSE;

EID: 0035179136     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod65.6.1663     Document Type: Article

References (25)

1. A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal
2. Sertoli cell signaling by Desert hedgehog regulates the male germline
3. Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules
4. Characterization of two patched receptors for the vertebrate hedgehog protein family
5. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
6. Gli proteins and hedgehog signaling: Development and cancer
7. The sonic hedgehog-patched-Gli pathway in human development and disease
8. Developmental pathways: Sonic hedgehog-patched-GLI
9. Transducing Hedgehog: The story so far
10. Catching a glimpse of hedgehog
11. Gli family members are differentially expressed during the mitotic phase of spermatogenesis
12. + ribonucleic acids are enriched in spermatocyte nuclei but not in chromatoid bodies in the rat testis
13. GLI activates transcription through a herpes simplex viral protein 16-like activation domain
14. Chromosomal progression of malignant human gliomas from biopsy to establishment as permanent lines in vitro
15. Identification of an amplified, highly expressed gene in a human glioma
16. Expression of human GLI in mice results in failure to thrive, early death, and patchy Hirschsprung-like gastrointestinal dilatation
17. Immunohistochemical localization of LDH-x during spermatogenesis in mouse testes
18. The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
19. The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels
20. Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation
21. Sonic hedgehog opposes epithelial cell cycle arrest
22. Gli genes in development and cancer
23. Gli, a zinc Anger transcription factor and oncogene, is expressed during normal mouse development
24. Sending and receiving the hedgehog signal: Control by the Drosophila Gli protein cubitus interruptus