Biodegradable PLGA microspheres as a sustained release system for a new Luteinizing Hormone-Releasing Hormone (LHRH) antagonist

Chemical and Pharmaceutical Bulletin

Volumn 54, Issue 9, 2006, Pages 1259-1265

  Du, Lina ^a   Cheng, Junping ^a   Chi, Qiang ^a   Qie, Jiankun ^a   Liu, Yan ^a   Mei, Xingguo ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Luteinizing hormone releasing hormone (LHRH) antagonist; Microspheres; Poly(DL lactide co glycolide); Testosterone level

Indexed keywords

GONADORELIN ANTAGONIST; LUTEINIZING HORMONE; LXT 101; MICROSPHERE; POLYGLACTIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIODEGRADATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; DRUG RELEASE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PARTICLE SIZE; RAT; SCANNING ELECTRON MICROSCOPY; SOLVENT EXTRACTION; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; TESTIS SIZE; TESTOSTERONE BLOOD LEVEL;

ANIMALS; COUMARINS; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; GONADOTROPIN-RELEASING HORMONE; LACTIC ACID; MALE; MICROSPHERES; MOLECULAR CONFORMATION; OLIGOPEPTIDES; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; TESTIS; TESTOSTERONE; TIME FACTORS;

EID: 33748454642     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.54.1259     Document Type: Article

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