Dextran sulfate sodium-induced colitis is associated with enhanced low molecular mass polypeptide 2 (LMP2) expression and is attenuated in LMP2 knockout mice

Digestive Diseases and Sciences

Volumn 51, Issue 7, 2006, Pages 1269-1276

  Fitzpatrick, Leo R ^a   Khare, Vineeta ^a   Small, Jeffrey S ^a   Koltun, Walter A ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Colitis; Dextran sulfate sodium; Immunoproteasome; Low molecular mass polypeptide 2; Mice

Indexed keywords

DEXTRAN SULFATE; DRINKING WATER; LOW MOLECULAR MASS POLYPEPTIDE 2; POLYPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLITIS; CONTROLLED STUDY; DESCENDING COLON; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYMPTOM; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; COLITIS; COLON; CYSTEINE ENDOPEPTIDASES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1; MICE; MICE, KNOCKOUT; TIME FACTORS;

EID: 33748433821     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-006-8047-2     Document Type: Article

References (27)

1. Mountz JD: Significance of increased circulating proteasomes in autoimmune disease. J Rheum 29:2045-2052, 2002
2. Groettrup M, Schmidtke G: Selective proteasome inhibitors: modulators of antigen presentation. Drug Dev Ther 4:63-71, 1999
3. Groettrup M, Khan S, Schwartz K: Interferon-γ inducible exchanges of 20S proteasome active site subunits: Why? Biochimie 83:367-372, 2002
4. Hayashi T, Faustman D: Essential role of human leukocyte antigen-encoded proteasome subunits in NF-κB activation and prevention of tumor necrosis factor-α induced apoptosis. J Biol Chem 275:5238-5247, 2000
5. Aki M, Shimbara N, Takashina M, Akiyama K, Kagawa S, Tamura T, Tanahashi N, Yoshimura T, Tanaka K, Ichihara A: Interferon-γ induces different subunit organizations and functional diversity of proteasomes. J Biochem 115:257-269, 1994
6. Stohwasser R, Giesebrecht J, Kraft R, Muller EC, Hausler G, Kettenman H, Hanisch UW, Kloetzel PM: Biochemical analysis of proteasomes from mouse microglia: induction of immunoproteasomes by interferon-γ and lipopolysaccaride. Glia 29:355-365, 2000
7. Fitzpatrick LR, Khare V, Koltun WA: Immunoproteasome induction in a lymphocyte cell line and in mice with dextran sulfate sodium-induced colitis. Gastroenterology 126:A-417, 2004
8. Kuckelhorn U, Ruppert T, Strehl B, Jungblut PR, Zimny-Ardt U, Lamer S, Prinz I, Drung I, Kloetzel PM, Kaufmann SH, Steinhoff U: Link between organ-specific antigen processing by 20S proteasomes and CD8+ T cell-mediated autoimmunity. J Exp Med 195:983-990, 2002
9. Egger B, Elliott MB, MacDonald TT, Inglin R, Eysselein VE, Buchler MW: Characterization of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency. Digestion 62:240-248, 2000
10. Lum T, Kerwar SS, Meyer SM, Nelson MG, Schow SR, Shiffman D, Wick MM, Joly AL: A new structural class of proteasome inhibitors that prevent NF-κB activation. Biochem Pharmacol 55:1391-1397, 1998
11. Echseveria CG: Recent advances in the identification and development of 20S proteasome inhibitors. Mini Rev Med Chem 2:247-259, 2002
12. Murthy SNS, Cooper HS, Shim H, Shah RS, Ibrahim SA, Sedergan DJ: Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporine. Dig Dis Sci 38:1722-1734, 1993
13. Williams KL, Fuller CR, Dieleman LA, DaCosta CM, Haldeman KM, Sartor RB, Lund PK: Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone. Gastroenterology 120:925-937, 2001
14. Krieglstein CF, Cerwinka WH, Laroux FS, Grisham MB, Schurmann G, Bruwer M, Granger DN: Role of appendix and spleen in experimental colitis. J Surg Res 101:166-175, 2001
15. Fitzpatrick LR, Wang J, Le T: Gliotoxin, an inhibitor of nuclear factor-kappa B, attenuates peptidoglycan-polysaccharide-induced colitis in rats. Inflammatory Bowel Diseases 8:159-167, 2002
16. Fitzpatrick LR, Wang J, Le T: In vitro and in vivo effects of gliotoxin, a fungal metabolite: efficacy against dextran sodium sulfate-induced colitis in rats. Dig Dis Sci 45:2327-2336, 2000
17. Barcelo-Batlori S, Andre M, Servis C, Levy N, Takikawa O, Michetti P, Reymond M, Felley-Bosco E: Proteomic analysis of cytokine induced proteins in human intestinal epithelial cells: Implications for inflammatory bowel diseases. Proteomics 2:551-560, 2002
18. Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R: A novel method of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98:694-702, 1990
19. Cooper HS, Murthy SNS, Shah RS, Sedergran DJ: Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69:238-249, 1993
20. Gaudio E, Taddei G, Vetuschi A, Sferrea R, Frieri G, Ricciardi G, Caprilli R: Dextran sulfate sodium (DSS) colitis in rats. Clinical, structural and ultrastructural aspects. Dig Dis Sci 44:1458-1475, 1999
21. Schottelius AJG, Baldwin AS: A role for transcription factor NF-κB in intestinal inflammation. Int J Colorect Dis14:18-28, 1999
22. Jobin C, Sartor RB: NF-κB signaling proteins as therapeutic targets for inflammatory bowel diseases. Inflammatory Bowel Diseases 6:206-213, 2000
23. Jobin C, Sartor RB: The IκB/NF-κB system. a key determinant of mucosal inflammation and protection. Am J Physiol Cell Physiol 278:C451-C462, 2000
24. Siegmund B, Lehr HA, Fantuzzi G, Dinarello CA: IL-1β-converting enzyme (caspase-1) in intestinal inflammation. Proc Natl Acad Sci USA 98:13249-13254, 2001
25. Siegmund B: Interleukin-1β-converting enzyme (caspase-1) in intestinal inflammation. Biochem Pharmacol 64:1-8, 2002
26. Loher F, Bauer C, Landauer N, Schmall K, Siegmund B, Lehr HA, Dauer M, Schoenharting M, Endres S, Aigler A: The interleukin-1β converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation. J PET 308:583-590, 2004
27. Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M: Nod2 mutation in crohn's disease potentiates NF-κB activity and IL-1β processing. Science 307:734-738, 2005