Acidic hydrolysis as a mechanism for the cleavage of the Glu298 → Asp variant of human endothelial nitric-oxide synthase

Journal of Biological Chemistry

Volumn 276, Issue 28, 2001, Pages 26674-26679

  Fairchild, Todd A ^a   Fulton, David ^a   Fontana, Jason T ^a   Gratton, Jean Philippe ^a   McCabe, Timothy J ^a   Sessa, William C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR SYSTEM; ENZYME KINETICS; GENES; HYDROLYSIS; PH EFFECTS;

CLEAVAGE MECHANISMS;

BIOCHEMISTRY;

AMINO ACID; ASPARTIC ACID; GLUTAMIC ACID; NITRIC OXIDE SYNTHASE; RECOMBINANT ENZYME; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CARDIOVASCULAR DISEASE; CELL CULTURE; CELL LYSATE; ENDOTHELIUM CELL; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE FREQUENCY; GENETIC POLYMORPHISM; HYDROLYSIS; NONHUMAN; PH; PRIORITY JOURNAL; TEMPERATURE; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; WESTERN BLOTTING; AMINO ACID SUBSTITUTION; CHEMISTRY; GENETICS; HUMAN; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ANIMALIA; ESCHERICHIA COLI;

AMINO ACID SUBSTITUTION; ASPARTIC ACID; GLUTAMIC ACID; HUMANS; HYDROLYSIS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035854834     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.m103647200     Document Type: Article

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