Complex relationship between changes in oxygenation status and changes in R2*: The case of insulin and NS-398, two inhibitors of oxygen consumption

Magnetic Resonance in Medicine

Volumn 56, Issue 3, 2006, Pages 637-643

  Jordan, Bénédicte F ^a   Crokart, Nathalie ^a   Baudelet, Christine ^a   Cron, Greg O ^a   Ansiaux, Réginald ^a   Gallez, Bernard ^a,b  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b CMFA/REMA   (Belgium)

Author keywords

BOLD MRI; GRE MRI; Oxygenation; Perfusion; Tumor

Indexed keywords

BLOOD; ELECTRON SPIN RESONANCE SPECTROSCOPY; HEMODYNAMICS; INSULIN; MAGNETIC RESONANCE IMAGING; OXYGEN; OXYGENATION; PARAMAGNETIC RESONANCE;

BLOOD OXYGEN LEVEL DEPENDENTS; COMPLEX RELATIONSHIPS; DYNAMIC CONTRAST ENHANCED MRIS (DCE); ELECTRON PARAMAGNETIC RESONANCES (EPR); METABOLIC CHANGES; OXYGEN CONSUMPTION; PERFUSION; RADIO-SENSITIZATION;

TUMORS;

INSULIN; MONOCOMPONENT INSULIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; OXYGEN; VASOACTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; BLOOD OXYGEN TENSION; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DYNAMIC CONTRAST ENHANCED MAGNETIC RESONANCE IMAGING; ELECTRON SPIN RESONANCE; FIBER OPTICS; HEMODYNAMIC MONITORING; IMAGING SYSTEM; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIMETRY; OXYGEN BLOOD LEVEL; OXYGEN CONSUMPTION; OXYGENATION; PERFUSION WEIGHTED IMAGING; RADIOLOGICAL PARAMETERS; RADIOSENSITIZATION; TUMOR BLOOD FLOW; TUMOR MODEL;

EID: 33748375574     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.20963     Document Type: Article

References (24)

1. Ogawa S, Lee TM, Nayak AS, Glynn P. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 1990;14:68-78.
2. Hennig J, Speck O, Koch MA, Weiller C. Functional magnetic resonance imaging: a review of methodological aspects and clinical applications. J Magn Reson Imaging 2003;18:1-15.
3. Griffiths JR, Taylor NJ, Howe FA, Saunders MI, Robinson SP, Hoskin PJ, Powell ME, Thoumine M, Caine LA, Baddeley H. The response of human tumors to carbogen breathing, monitored by gradient-recalled echo magnetic resonance imaging. Int J Radiat Oncol Biol Physiol 1997;39:697-701.
4. Howe FA, Robinson SP, Rodrigues LM, Stubbs M, Griffiths JR. Issues in GRE & SE magnetic resonance imaging to probe tumor oxygenation. Adv Exp Med Biol 2003;530:441-448.
5. Karczmar GS, River JN, Li J, Vijayakumar S, Goldman Z, Lewis MZ. Effects of hyperoxia on T2* and resonance frequency weighted magnetic resonance images of rodent tumours. NMR Biomed 1994;7:3-11.
6. Robinson SP, Collingridge DR, Howe FA, Rodrigues LM, Chaplin DJ, Griffiths JR. Tumour response to hypercapnia and hyperoxia monitored by FLOOD magnetic resonance imaging. NMR Biomed 1999;12:98-106.
7. Baudelet C, Gallez B. Current issues in the utility of blood oxygen level dependent MRI for the assessment of modulations in tumor oxygenation. Curr Med Imaging Rev 2005;1:229-249.
8. Al Hallaq HA, River JN, Zamora M, Oikawa H, Karczmar GS. Correlation of magnetic resonance and oxygen microelectrode measurements of carbogen-induced changes in tumor oxygenation. Int J Radiat Oncol Biol Physiol 1998;41:151-159.
9. Baudelet C, Gallez B. How does blood oxygen level-dependent (BOLD) contrast correlate with oxygen partial pressure (pO2) inside tumors? Magn Reson Med 2002;48:980-986.
10. Fan X, River JN, Zamora M, Al Hallaq HA, Karczmar GS. Effect of carbogen on tumor oxygenation: combined fluorine-19 and proton MRI measurements. Int J Radiat Oncol Biol Physiol. 2002;54:1202-1209.
11. Rodrigues LM, Howe FA, Griffiths JR, Robinson SP. Tumor R2* is a prognostic indicator of acute radiotherapeutic response in rodent tumors. J Magn Reson Imaging 2004;19:482-488.
12. Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989;49:6449-6465.
13. Jordan BF, Gregoire V, Demeure RJ, Sonveaux P, Feron O, O'Hara J, Vanhulle VP, Delzenne N, Gallez B. Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption. Cancer Res 2002;62:3555-3561.
14. Secomb TW, Hsu R, Ong ET, Gross JF, Dewhirst MW. Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol 1995;34:313-316.
15. Crokart N, Radermacher K, Jordan BF, Baudelet C, Cron GO, Gregoire V, Beghein N, Bouzin C, Feron O, Gallez B. Tumor radiosensitization by antiinflammatory drugs: evidence for a new mechanism involving the oxygen effect. Cancer Res 2005;65:7911-7916.
16. Baudelet C, Ansiaux R, Jordan BF, Havaux X, Macq B, Gallez B. Physiological noise in murine solid tumours using T2*-weighted gradient-echo imaging: a marker of tumour acute hypoxia? Phys Med Biol 2004;49:3389-3411.
17. Fan X, Medved M, River JN, Zamora M, Corot C, Robert P, Bourrinet P, Lipton M, Gulp RM, Karczmar GS. New model for analysis of dynamic contrast-enhanced MRI data distinguishes metastatic from nonmetastatic transplanted rodent prostate tumors. Magn Reson Med 2004;51:487-494.
18. Baudelet C, Gallez B. Cluster analysis of BOLD fMRI time series in tumors to study the heterogeneity of hemodynamic response to treatment. Magn Reson Med 2003;49:985-990.
19. Gallez B, Baudelet C, Jordan BF. Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications. NMR Biomed 2004;17:240-262.
20. Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, Larsson HB, Lee TY, Mayr NA, Parker GJ, Port RE, Taylor J, Weisskoff RM. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 1999;10:223-232.
21. Gallez B, Jordan BF, Baudelet C, Misson PD. Pharmacological modifications of the partial pressure of oxygen in murine tumors: evaluation using in vivo EPR oximetry. Magn Reson Med 1999;42:627-630.
22. Snyder SA, Lanzen JL, Braun RD, Rosner G, Secomb TW, Biaglow J, Brizel DM, Dewhirst MW. Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone. Int J Radiat Oncol Biol Physiol 2001;51:494-506.
23. Burd R, Lavorgna SN, Daskalakis C, Wachsberger PR, Wahl ML, Biaglow JE, Stevens CW, Leeper DB. Tumor oxygenation and acidification are increased in melanoma xenografts after exposure to hyperglycemia and meta-iodo- benzylguanidine. Radiat Res 2003;159:328-335.
24. Al Hallaq HA, Fan X, Zamora M, River JN, Moulder JE, Karczmar GS. Spectrally inhomogeneous BOLD contrast changes detected in rodent tumors with high spectral and spatial resolution MRI. NMR Biomed 2002;15:28-36.