Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel

Journal of the American Chemical Society

Volumn 128, Issue 35, 2006, Pages 11591-11599

  Valiyaveetil, Francis I ^a,c   Sekedat, Matthew ^a   MacKinnon, Roderick ^a,b   Muir, Tom W ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MODIFICATION; ESTERS; HYDRATION; POSITIVE IONS; PROTEINS;

CONDUCTING IONS; ION BINDING SITES; POTASSIUM CHANNEL; SELECTIVITY FILTER;

SUBSTITUTION REACTIONS;

POTASSIUM CHANNEL;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; ION CONDUCTANCE; MOLECULAR MIMICRY; POTASSIUM CONDUCTANCE; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RECEPTOR OCCUPANCY; WILD TYPE; X RAY CRYSTALLOGRAPHY;

AMIDES; ANIMALS; BINDING SITES; CELLS, CULTURED; CESIUM; CRYSTALLOGRAPHY, X-RAY; ELECTROPHYSIOLOGY; ESTERS; ION CHANNEL GATING; LIPID BILAYERS; MICE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; POTASSIUM CHANNELS; PROTEIN CONFORMATION; RUBIDIUM;

EID: 33748360106     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0631955     Document Type: Article

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