Helicobacter pylori infection stimulates intestinalization of endocrine cells in glandular stomach of Mongolian gerbils

Cancer Science

Volumn 97, Issue 10, 2006, Pages 1015-1022

  Takenaka, Yoshiharu ^a,b   Tsukamoto, Tetsuya ^a   Mizoshita, Tsutomu ^a   Cao, Xueyuan ^a   Ban, Hisayo ^a   Ogasawara, Naotaka ^a   Kaminishi, Michio ^b   Tatematsu, Masae ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; CHROMOGRANIN A; COMPLEMENTARY DNA; GASTRIC INHIBITORY POLYPEPTIDE; GASTRIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA SEQUENCE; ENDOCRINE CELL; GENE EXPRESSION; GERBIL; HELICOBACTER INFECTION; HELICOBACTER PYLORI; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; INTESTINE CELL; INTESTINE METAPLASIA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHENOTYPIC VARIATION; PRECANCER; PRIORITY JOURNAL; PYLORUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; STOMACH CANCER; STOMACH GLAND;

ANIMALS; CHROMOGRANIN A; CHROMOGRANINS; ENDOCRINE GLANDS; GASTRIC INHIBITORY POLYPEPTIDE; GASTRIC MUCOSA; GASTRINS; GERBILLINAE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; IMMUNOHISTOCHEMISTRY; INTESTINES; METAPLASIA; PRECANCEROUS CONDITIONS; RNA, MESSENGER; STOMACH; STOMACH NEOPLASMS;

EID: 33748335412     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2006.00273.x     Document Type: Article

References (44)

1. Hirayama F, Takagi S, Yokoyama Y, Iwao E, Ikeda Y. Establishment of gastric Helicobacter pylori infection in Mongolian gerbils. J Gastroenterol 1996; 31 (Suppl. 9): 24-8.
2. Nozaki K, Shimizu N, Ikehara Y et al. Effect of early eradication on Helicobacter pylori -related gastric carcinogenesis in Mongolian gerbils. Cancer Sci 2003; 94: 235-9.
3. Wong BC, Lam SK, Wong WM et.al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: A randomized controlled trial. JAMA 2004; 291: 187-94.
4. Bordi C, Ravazzola M. Endocrine cells in the intestinal metaplasia of gastric mucosa. Am J Pathol 1979; 96: 391-8.
5. Mingazzini P, Carlei F, Malchiodi-Albedi F et.al. Endocrine cells in intestinal metaplasia of the stomach. J Pathol 1984; 144: 171-8.
6. Tsutsumi Y, Nagura H, Watanabe K, Yanaihara N. A novel subtyping of intestinal metaplasia of the stomach, with special reference to the histochemical characterizations of endocrine cells. Virchows Arch A Pathol Anat Histopathol 1983; 401: 73-88.
7. Kagawa J, Honda S, Kodama M, Sato R, Murakami K, Fujioka T. Enterocromaffin-like cell tumor induced by Helicobacter pylori infection in Mongolian gerbils. Helicobacter 2002; 7: 390-7.
8. Hirayama F, Takagi S, Yokoyama Y, Yamamoto K, Iwao E, Haga K. Long-term effects of Helicobacter pylori eradication in Mongolian gerbils. J Gastroenterol 2002; 37: 779-84.
9. Hirayama F, Takagi S, Iwao E, Yokoyama Y, Haga K, Hanada S. Development of poorly differentiated adenocarcinoma and carcinoid due to long-term Helicobacter pylori colonization in Mongolian gerbils. J Gastroenterol 1999; 34: 450-4.
10. Oberg K. Gastric neuroendocrine cells and secretory products. Yale J Biol Med 1998; 71: 149-54.
11. Owen DA. Normal histology of the stomach. Am J Surg Pathol 1986; 10: 48-61.
12. Sjolund K, Sanden G, Hakanson R, Sundler F. Endocrine cells in human intestine: An immunocytochemical study. Gastroenterology 1983; 85: 1120-30.
13. Hocker M, Wiedenmann B. Molecular mechanisms of enteroendocrine differentiation. Ann NY Acad Sci 1998; 859: 160-74.
14. Otsuka T, Tsukamoto T, Mizoshita T et al. Coexistence of gastric-and intestinal-type endocrine cells in gastric and intestinal mixed intestinal metaplasia of the human stomach. Pathol Int 2005; 55: 170-9.
15. Tatematsu M, Tsukamoto T, Inada K. Stem cells and gastric cancer: Role of gastric and intestinal mixed intestinal metaplasia. Cancer Sci 2003; 94: 135-41.
16. Shimizu N, Inada K, Nakanishi H et al. Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens. Carcinogenesis 1999; 20: 669-76.
17. Shimizu N, Ikehara Y, Inada K et al. Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils. Cancer Res 2000; 60: 1512-14.
18. Cao X, Tsukamoto T, Nozaki K et al. Earlier Helicobacter pylori infection increases the risk for the N-methyl-N -nitrosourea-induced stomach carcinogenesis in Mongolian gerbils. Jpn J Cancer Res 2002; 93: 1293-8.
19. Cao X, Tsukamoto T, Nozaki K et al. Eradication of Helicobacter pylori induces apoptosis and inhibits proliferation of heterotopic proliferative glands in infected Mongolian gerbils. Cancer Sci 2004; 95: 872-7.
20. Tsukamoto T, Inada K, Tanaka H et al. Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: Inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia. J Cancer Res Clin Oncol 2004; 130: 135-45.
21. Mizoshita T, Tsukamoto T, Takenaka Y et al. Gastric and intestinal phenotypes and histogenesis of advanced glandular stomach cancers in carcinogen-treated, Helicobacter pylori-infected Mongolian gerbils. Cancer Sci 2006; 97: 38-44.
22. Tatematsu M, Tsukamoto T, Mizoshita T. Role of Helicobacter pylori in gastric carcinogenesis: The origin of gastric cancers and heterotopic proliferative glands in Mongolian gerbils. Helicobacter 2005; 10: 97-106.
23. Nozaki K, Shimizu N, Tsukamoto T et al. Reversibility of heterotopic proliferative glands in glandular stomach of Helicobacter pylori-infected Mongolian gerbils on eradication. Jpn J Cancer Res 2002; 93: 374-81.
24. Mizoshita T, Joh T, Oshima T et al. Differential expression of decay-accelerating factor isoforms in the digestive tract of guinea pig. Life Sci 2002; 70: 867-76.
25. Tsukamoto T, Fukami H, Yamanaka S et al. Hexosaminidase-altered aberrant crypts, carrying decreased hexosaminidase alpha and beta subunit mRNAs, in colon of 1,2-dimethylhydrazine-treated rats. Jpn J Cancer Res 2001; 92: 109-18.
26. Sugiyama A, Ikeno T, Maruta F et al. Long-term Helicobacter pylori colonization produces G cell hyperplasia and carcinoid tumor in Mongolian gerbils. J Cell Mol Med 2000; 4: 308-9.
27. Sumii M, Sumii K, Tari A et al. Expression of antral gastrin and somatostatin mRNA in Helicobacter pylori-infected subjects. Am J Gastroenterol 1994; 89: 1515-19.
28. Sokic-Milutinovic A, Todorovic V, Milosavljevic T, Micev M, Drndarevic N, Mitrovic O. Gastrin and antral G cells in course of Helicobacter pylori eradication: Six months follow up study. World J Gastroenterol 2005; 11: 4140-7.
29. Graham DY, Lew GM, Lechago J. Antral G-cell and D-cell numbers in Helicobacter pylori infection: Effect of H. pylori eradication. Gastroenterology 1993; 104: 1655-60.
30. Kamada T, Haruma K, Kawaguchi H, Yoshihara M, Sumii K, Kajiyama G. The association between antral G and D cells and mucosal inflammation, atrophy, and Helicobacter pylori infection in subjects with normal mucosa, chronic gastritis, and duodenal ulcer. Am J Gastroenterol 1998; 93: 748-52.
31. Dimaline R, Evans D, Forster ER, Sandvik AK, Dockray GJ. Control of gastric corpus chromogranin A messenger RNA abundance in the rat. Am J Physiol 1993; 264: G583-8.
32. Tsutsumi Y, Nagura H, Watanabe K. Immune aspects of intestinal metaplasia of the stomach: An immunohistochemical study. Virchows Arch A Pathol Anat Histopathol 1984; 403: 345-59.
33. Salenius P. On the ontogenesis of the human gastric epithelial cells. A histologic and histochemical study. Acta Anat (Basel) 1962; 50 (Suppl. 46): 1-76.
34. La Rosa S, Rigoli E, Uccella S, Chiaravalli AM, Capella C. CDX2 as a marker of intestinal EC-cells and related well-differentiated endocrine tumors. Virchows Arch 2004; 445: 248-54.
35. Jenny M, Uhl C, Roche C et al. Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J 2002; 21: 6338-47.
36. Sakai H, Eishi Y, Li XL et al. PDX1 homeobox protein expression in pseudopyloric glands and gastric carcinomas. Gut 2004; 53: 323-30.
37. Faller G, Kirchner T. Immunological and morphogenic basis of gastric mucosa atrophy and metaplasia. Virchows Arch 2005; 446: 1-9.
38. Suzuki H, Minegishi Y, Nomoto Y et al. Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils. J Pathol 2005; 206: 186-97.
39. -nitro-N-nitrosoguanidine. Carcinogenesis 1988; 9: 495-8.
40. Tatematsu M, Furihata C, Katsuyama T et al. Immunohistochemical demonstration of pyloric gland-type cells with low-pepsinogen isozyme 1 in preneoplastic and neoplastic tissues of rat stomachs treated with N-methyl-N'-nitro-N-nitrosoguanidine. J Natl Cancer Inst 1987; 78: 771-7.
41. Tatematsu M, Mutai M, Aoki T, de Camargo JL, Furihata C, Ito N. Proliferation kinetics of pepsinogen altered pyloric gland cells in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis 1989; 10: 907-11.
42. Saito A, Shimoda T, Nakanishi Y, Ochiai A, Toda G. Histologic heterogeneity and mucin phenotypic expression in early gastric cancer. Pathol Int 2001; 51: 165-71.
43. Koseki K, Takizawa T, Koike M, Ito M, Nihei Z, Sugihara K. Distinction of differentiated type early gastric carcinoma with gastric type mucin expression. Cancer 2000; 89: 724-32.
44. Egashira Y, Shimoda T, Ikegami M. Mucin histochemical analysis of minute gastric differentiated adenocarcinoma. Pathol Int 1999; 49: 55-61.