FcγRIII engagement provides activating signals to NKT cells in antibody-induced joint inflammation

Journal of Clinical Investigation

Volumn 116, Issue 9, 2006, Pages 2484-2492

  Hye, Young Kim ^a   Kim, Sanghee ^b   Doo, Hyun Chung ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; CYTOKINE; FC RECEPTOR; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA; FCGR3 PROTEIN, MOUSE; INTERLEUKIN DERIVATIVE; PRIMER DNA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CELL SURFACE; CELL TRANSFER; CONTROLLED STUDY; FLOW CYTOMETRY; HISTOLOGY; IMMUNOGLOBULIN AGGREGATE; INFLAMMATION; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILD TYPE; ANIMAL; ARTHROPATHY; BIOSYNTHESIS; CELL LINE; GENETICS; IMMUNOLOGY; NATURAL KILLER CELL; NONOBESE DIABETIC MOUSE; PHYSIOLOGY; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; ARTHRITIS, EXPERIMENTAL; CELL LINE; DNA PRIMERS; IMMUNOGLOBULIN G; INFLAMMATION; INTERFERON TYPE II; INTERLEUKINS; JOINT DISEASES; KILLER CELLS, NATURAL; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; RECEPTORS, IGG; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 33748296238     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI27219     Document Type: Article

References (30)

1. - T cells in mice and humans. J. Exp. Med. 180:1097-1106.
2. Bendelac, A. 1995. CD1: presenting unusual antigens to unusual T lymphocytes. Science. 269:185-186.
3. Kawano, T., et al. 1997. CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science. 278:1626-1629.
4. + T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1. J. Immunol. 159:2240-2249.
5. Taniguchi, M., Harada, M., Kojo, S., Nakayama, T., and Wakao, H. 2003. The regulatory role of Valpha14 NKT cells in innate and acquired immune response. Annu. Rev. Immunol. 21:483-513.
6. Beaudoin, L., Laloux, V., Novak, J., Lucas, B., and Lehuen, A. 2002. NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic beta cells. Immunity. 17:725-736.
7. Singh, A.K., et al. 2001. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J. Exp. Med. 194:1801-1811.
8. Kim, H.Y., et al. 2005. NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor β1 production. J. Exp. Med. 201:41-47.
9. Kim, J.H., et al. 2005. Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-γ. Am. J. Pathol. 167:1231-1241.
10. Zeng, D., Liu, Y., Sidobre, S., Kronenberg, M., and Strober, S. 2003. Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus. J. Clin. Invest. 112:1211-1222. doi:10.1172/JCI200317165.
11. Gumperz, J.E., et al. 2000. Murine CD1d-restricted T cell recognition of cellular lipids. Immunity. 12:211-221.
12. Ji, H., et al. 2002. Arthritis critically dependent on innate immune system players. Immunity. 16:157-168.
13. Corr, M., and Crain, B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J. Immunol. 169:6604-6609.
14. Takai, T. 2002. Roles of Fc receptors in autoimmunity. Nat. Rev. Immunol. 2:580-592.
15. - cells. J. Exp. Med. 179:1957-1972.
16. Unkeless, J.C. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150:580-596.
17. Takai, T., Li, M., Sylvestre, D., Clynes, R., and Ravetch, J.V. 1994. FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell. 76:519-529.
18. Nimmerjahn, F., Bruhns, P., Horiuchi, K., and Ravetch, J.V. 2005. FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Immunity. 23:41-51.
19. Marcilla, A., Rivero-Lezcano, O.M., Agarwal, A., and Robbins, K.C. 1995. Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors. J. Biol. Chem. 270:9115-9120.
20. Crowley, M.T., et al. 1997. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J. Exp. Med. 186:1027-1039.
21. Szabo, S.J., et al. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 100:655-669.
22. Ouyang, W., et al. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity. 9:745-755.
23. Hayakawa, Y., et al. 2001. Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. J. Immunol. 166:6012-6018.
24. Kaneda, H., et al. 2005. ICOS costimulates invariant NKT cell activation. Biochem. Biophys. Res. Commun. 327:201-207.
25. Kim, H.J., Kim, H.Y., Kim, B.K., Kim, S., and Chung, D.H. 2006. Engagement of glucocorticoid-induced TNF receptor costimulates NKT cell activation in vitro and in vivo. J. Immunol. 176:3507-3515.
26. Butkiewicz, L., Duriagin, S., Laddach, R., Chwalinska-Sadowska, H., and Jagodzinski, P.P. 2005. Prevalence of Fc-gammaR chain expression in CD4+ T cells of patients with systemic lupus erythematosus. Scand. J. Rheumatol. 34:216-219.
27. Abdul-Majid, K.B., et al. 2002. Fc receptors are critical for autoimmune inflammatory damage to the central nervous system in experimental autoimmune encephalomyelitis. Scand. J. Immunol. 55:70-81.
28. Bruhns, P., Samuelsson, A., Pollard, J.W., and Ravetch, J.V. 2003. Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease. Immunity. 18:573-581.
29. Marino, M., Ruvo, M., De Falco, S., and Fassina, G. 2000. Prevention of systemic lupus erythematosus in MRL/lpr mice by administration of an immunoglobulin-binding peptide. Nat. Biotechnol. 18:735-739.
30. Kim, S.L.S., Lee, T., Jung, S., and Kim, D. 2004. Practical synthesis of KRN7000 form phytosphingosine. Synthesis. 22:847-850.