Brain glutathione content and glutamate uptake are reduced in rats exposed to pre- and postnatal protein malnutrition

Journal of Nutrition

Volumn 136, Issue 9, 2006, Pages 2357-2361

  Feoli, Ana Maria ^a,b   Siqueira, Ionara ^b   Almeida, Lucia Maria V ^b   Tramontina, Ana Carolina ^b   Battu, Cíntia ^b   Wofchuk, Susana T ^b   Gottfried, Carmem ^b   Perry, Marcos Luiz ^b   Gonçalves, Carlos Alberto ^b  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE PEROXIDASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPUS; LIPID PEROXIDATION; NONHUMAN; PROTEIN MALNUTRITION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RAT;

EID: 33748286940     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.9.2357     Document Type: Article

References (36)

1. Wu G, Haynes TE, Li H, Yan W, Meininger CJ. Glutamine metabolism to glucosamine is necessary for glutamine inhibition of endothelial nitric oxide synthesis. Biochem J. 2001;353:245-52.
2. Mates JM, Peres-Gomes C, Nunez de Castro I, Asenio M, Marquez J. Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death. Int J Biochem Cell Biol. 2002;34:439-58.
3. Li J, Wang H, Stoner GD, Bray TM. Dietary supplementation with cysteine prodrugs selectively restores tissue glutathione levels and redox status in protein-malnourished mice (1). J Nutr Biochem. 2002;13:625-33.
4. Steiger JL, Alexander MJ, Galler JR, Farb DH, Russek SJ. Effects of prenatal malnutrition on GABAA receptor alpha1, alpha3 and beta2 mRNA levels. Neuroreport. 2003;14:1731-5.
5. Rotta LN, Schmidt AP, Mello e Souza T, Nogueira CW, Souza KB, Izquierdo IA, Perry ML, Souza DO. Effects of undernutrition on glutamatergic parameters in rat brain. Neurochem Res. 2003;28:1181-6.
6. Araque A, Perea G. Glial modulation of synaptic transmission in culture. Glia. 2004;47:241-8.
7. Takuma K, Baba A, Matsuda T. Astrocyte apoptosis: implications for neuroprotection. Prog Neurobiol. 2004;72:111-27.
8. Feoli AM, Siqueira IR, Almeida L, Tramontina AC, Vanzella C, Sbaraini S, Schweigert ID, Netto CA, Perry ML, et al. Effects of protein malnutrition on oxidative status in rat brain. Nutrition. 2006;22:160-5.
9. Bobyn PJ, Corbett D, Saucier DM, Noyan-Ashraf MH, Juurlink BH, Paterson PG. Protein-energy malnutrition impairs functional outcome in global ischemia. Exp Neurol. 2005;196:308-15.
10. Horwitz W. Official methods of analysis of the Association of Official Analytical Chemists (AOAC), Washington, DC, USA, 1980.
11. Schweigert I, de Oliveira DL, Scheibel F, da Costa F, Wofchuk ST, Souza D, Perry MLS. Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices. Brain Res Dev Brain Res. 2005;154:177-85.
12. Allen S, Shea JM, Felmet T, Gadra J, Dehn P. A kinetic microassay for glutathione in cells plated on 96-well microtiter plates. Methods Cell Sci. 2000;22:305-12.
13. Tietze F. Enzymatic method for quantitative determination of nanogram amount of total oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem. 1969;27:502-22.
14. Sriram K, Pai KS, Boyd MR, Ravindranath V. Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice. Brain Res. 1997;749:44-52.
15. Bromont C, Marie C, Bralet J. Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats. Stroke. 1989;20:918-24.
16. Lissi E, Salim-Hanna M, Pascual C, del Castillo MD. Evaluation of total antioxidant potential (TRAP) and total antioxidant reactivity from luminol-enhanced chemiluminescence measurements. Free Radic Biol Med. 1995;18:153-8.
17. Evelson P, Travacio M, Repetto M, Escobar J, Llesuy S, Lissi EA. Evaluation of total reactive antioxidant potential (TRAP) of tissue homogenates and their cytosols. Arch Biochem Biophys. 2001;388:261-6.
18. Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121-6.
19. Wendel A. Glutathione peroxidase. Methods Enzymol. 1981;77:325-33.
20. Petito CK, Chung MC, Verkhovsky LM, Cooper AJL. Brain glutamine synthetase increases following cerebral ischemia in the rat. Brain Res. 1992;569:275-80.
21. Thomazi AP, Godinho GF, Rodrigues JM, Schwalm FD, Frizzo ME, Moriguchi E, Souza DO, Wofchuk ST. Ontogenetic profile of glutamate uptake in brain structures slices from rats: sensitivity to guanosine. Mech Ageing Dev. 2004 Jul;125:475-81.
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193:265-75.
23. Morgane PJ, Mokler DJ, Galler JR. Effects of prenatal protein malnutrition on the hippocampal formation. Neurosci Biobehav Rev. 2002;26:471-83.
24. Nanda D, Tolputt J, Collard KJ. Changes in brain glutathione levels during postnatal development in the rat. Brain Res Dev Brain Res. 1996;94:238-41.
25. Lu SC. Regulation of glutathione synthesis. Curr Top Cell Regul. 2000;36:95-116.
26. Olorunsogo OO. Changes in brain mitochondrial bioenergetics in protein-deficient rats. Br J Exp Pathol. 1989;70:607-19.
27. Olorunsogo OO. Defective mitochondrial cation transport during dietary protein deficiency in rats. Afr J Med Med Sci. 1992;21:23-31.
28. Lujan R, Shigemoto R, Lopez-Bendito G. Glutamate and GABA receptor signalling in the developing brain. Neuroscience. 2005;130:567-80.
29. Furuta A, Rothstein JD, Martin LJ. Glutamate transporter protein subtypes are expressed differentially during rat CNS development. J Neurosci. 1997;17:8363-75.
30. Danbolt NC. Glutamate uptake. Prog Neurobiol. 2001;65:1-105.
31. Mates JM, Perez-Gomez C, Nunez de Castro I, Asenjo M, Marquez J. Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death. Int J Biochem Cell Biol. 2002;34:439-58.
32. Olalla L, Aledo JC, Bannenberg G, Marquez J. The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins. FEBS Lett. 2001;488:116-22.
33. Felipo V, Butterworth RF. Neurobiology of ammonia. Prog Neurobiol. 2002;67:259-79.
34. Patel AJ, Hunt A, Gordon RD, Balazs R. The activities in different neural cell types of certain enzymes associated with the metabolic compartmentation glutamate. Brain Res. 1982;256:3-11.
35. McBean GJ, Flynn J. Molecular mechanisms of cystine transport. Biochem Soc Trans. 2001;29:717-22.
36. Trotti D, Rizzini BL, Rossi D, Haugeto O, Racagni G, Danbolt NC, Volterra A. Neuronal and glial glutamate transporters possess na SH-based redox regulatory mechanism. Eur J Neurosci. 1997;9:1236-43.