Biological monitoring of exposure to organophosphorus insecticides in a group of horticultural greenhouse workers

Annals of Occupational Hygiene

Volumn 50, Issue 5, 2006, Pages 505-515

  Bouchard, Michèle ^a,b   Carrier, Gaétan ^a   Brunet, Robert C ^a   Dumas, Pierre ^b   Noisel, Nolwenn ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b INSTITUT NATIONAL DE SANTÉ PUBLIQUE DU QUÉBEC   (Canada)

Author keywords

Acephate; Biomonitoring; Diazinon; Malathion; Occupational exposure; Organophosphorus insecticides

Indexed keywords

AGRICULTURE; BIOMARKERS; CARBOXYLIC ACIDS; CONTAMINATION; GREENHOUSES; INSECTICIDES; METABOLITES; OCCUPATIONAL DISEASES; OCCUPATIONAL RISKS;

ACEPHATE; BIOMONITORING; DIAZINON; MALATHION; OCCUPATIONAL EXPOSURE; ORGANOPHOSPHORUS INSECTICIDES;

PATIENT MONITORING;

ACEPHATE; BIOLOGICAL MARKER; CARBOXYLIC ACID; DICARBOXYLIC ACID; DIMPYLATE; MALATHION; METHAMIDOPHOS; ORGANOPHOSPHATE INSECTICIDE; PHOSPHORIC ACID;

ARTICLE; BIOLOGICAL MONITORING; BODY WEIGHT; CONCENTRATION (PARAMETERS); ENVIRONMENTAL EXPOSURE; FOOD CONTAMINATION; GREENHOUSE; HEALTH HAZARD; HUMAN; INDUSTRIAL WORKER; KINETICS; METABOLITE; OCCUPATIONAL EXPOSURE; OCCUPATIONAL TOXICOLOGY; POPULATION EXPOSURE; PRIORITY JOURNAL; REFERENCE VALUE; URINALYSIS; URINARY EXCRETION; URINE LEVEL;

BIOLOGICAL MARKERS; ENVIRONMENTAL MONITORING; FEMALE; GARDENING; HUMANS; INSECTICIDES; MALE; OCCUPATIONAL EXPOSURE; ORGANOPHOSPHORUS COMPOUNDS;

AGRICULTURE; DISEASES;

EID: 33748109898     PISSN: 00034878     EISSN: 14753162     Source Type: Journal    
DOI: 10.1093/annhyg/mel005     Document Type: Article

References (37)

1. Barr DB, Bravo R, Weerasekera G et al. (2004) Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population. Environ Health Perspect; 112: 186-200.
2. Bouchard M, Gosselin NH, Brunet RC et al. (2003) A toxicokinetic model of malathion and its metabolites as a tool to assess human exposure and risk through measurements of urinary biomarkers. Toxicol Sci; 73: 182-94.
3. Bouchard M, Carrier G, Brunet RC et al. (2005) Determination of biological reference values for chlorpyrifos metabolites in human urine using a toxicokinetic model. J Occup Environ Health; 2: 155-68.
4. Bronaugh RL, Maibach HI. (1999) Percutaneous absorption. Drugs-cosmetics-mechanisms-methodology. 3rd edn. New York: Marcel Dekker.
5. Carrier G, Brunet RC. (1999) A toxicokinetic model to assess the risk of azinphosmethyl exposure in humans through measures of urinary elimination of alkylphosphates. Toxicol Sci; 47: 23-32.
6. CDC. (2005) Third national report on human exposure to environmental chemicals. Atlanta, Georgia: Department of Health and Human Services, Centers for Disease Control and Prevention. pp. 349-84.
7. Cocker J, Mason HJ, Garfitt SJ et al. (2002) Biological monitoring of exposure to organophosphate pesticides. Toxicol Lett; 134: 97-103.
8. Curl CL, Fenske RA, Elgethun K. (2003) Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets. Environ Health Perspect; 111: 377-82.
9. Cruz Márquez M, Arrebola FJ, Egea González FJ et al. (2001) Gas chromatographic-tandem mass spectrometric analytical method for the study of inhalation, potential dermal and actual exposure of agricultural workers to the pesticide malathion. J Chromatogr A; 939: 79-89.
10. Dennis GA, Lee PN. (1999) A phase 1 volunteer study to establish the degree of absorption and effect on cholinesterase activity of four head lice preparations containing malathion. Clin Drug Invest; 18: 105-15.
11. Dowling KC, Seiber JN. (2002) Importance of respiratory exposure to pesticides among agricultural populations. Int J Toxicol; 21: 371-81.
12. Feldmann RJ, Maibach HI. (1974) Percutaneous penetration of some pesticides and herbicides in man. Toxicol Appl Pharmacol; 28: 126-32.
13. Fenske RA, Leffingwell JT. (1989) Method for the determination of dialkyl phosphate metabolites in urine for studies of human exposure to malathion. J Agric Food Chem; 37: 995-8.
14. Fenske RA, Kedan G, Lu C et al. (2002a) Assessment of organophosphorous pesticide exposures in the diets of preschool children in Washington State. J Expo Anal Environ Epidemiol; 12: 21-8.
15. Fenske RA, Lu C, Barr D et al. (2002b) Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State. Environ Health Perspect; 110: 549-53.
16. Fenske RA, Lu C, Curl CL et al. (2005) Biologic monitoring to characterize organophosphorus pesticide exposure among children and workers: an analysis of recent studies in Washington State. Environ Health Perspect; 113: 1651-7.
17. Gil F, Pla A. (2001) Biomarkers as biological indicators of xenobiotic exposure. J Appl Toxicol; 21: 245-55.
18. Gosselin NH, Bouchard M, Brunet RC et al. (2005) Toxicokinetic modeling of parathion and its metabolites in humans for the determination of biological reference values. Toxicol Mech Methods; 15: 33-52.
19. Griffin P, Mason H, Heywood K et al. (1999) Oral and dermal absorption of chlorpyrifos: a human volunteer study. Occup Environ Med; 56: 10-13.
20. Jellinek, Schwartz and Connolly, Inc. (2000) The effects and pharmacological disposition of a single oral dose of malathion administered to human volunteers. Lemvig, Denmark Cheminova: Unpublished report, CHA Doc. No. 299 FYF Amdt-4. Submitted to EPA on 5/17/00, MRID 45125601.
21. Koelle GB. (1994) Pharmacology of organophosphates. J Appl Toxicol; 14: 105-9.
22. Krieger RI, Dinoff TM. (2000) Malathion deposition, metabolite clearance, and cholinesterase status of date dusters and harvester in California. Arch Environ Contam Toxicol; 38: 546-53.
23. Lauwerys R, Hoet P. (2001) Industrial chemical exposure: guidelines for biological monitoring. Boca Raton, FL: Lewis Publishers.
24. Lu C, Toepel K, Irish R et al. (2006) Organic diets significantly lower children's dietary exposure to organophosphorus pesticides. Environ Health Perspect; 114: 260-263.
25. Maibach HI, Feldmann RJ, Milby TH et al. (1971) Regional variation in percutaneous penetration in man: Pesticides. Arch Environ Health; 23: 208-11.
26. Moeller HC, Rider JA. (1962) Plasma and red blood cholinesterase activity as indications of the threshold of incipient toxicity of ethyl-p-nitrophenyl thionobenzene-phosphonate (EPN) and malathion in human beings. Toxicol Appl Pharmacol; 4: 123-30.
27. Morgan DP, Hetzler HL, Slach EF et al. (1977) Urinary excretion of paranitrophenol and alkyl phosphates following ingestion of methyl and ethyl parathion by human subjects. Arch Environ Contam Toxicol; 6: 159-73.
28. Olsson AO, Nguyen JV, Sadowski MA et al. (2003) A liquid chromatography/electrospray ionization-tandem mass spectrometry method for quantification of specific organophosphorus pesticide biomarkers in human urine. Anal Bioanal Chem; 376: 808-15.
29. Olsson AO, Baker SE, Nguyen JV et al. (2004) A liquid chromatography-tandem mass spectrometry multiresidue method for quantification of specific metabolites of organophosphorus pesticides, synthetic pyrethroids, selected herbicides, and deet in human urine. Anal Chem; 76: 2453-61.
30. Richter ED, Chuwers P, Levy Y. (1992) Health effects from exposure to organophosphate pesticides in workers and residents in Israel. Isr J Med Sci; 28: 584-98.
31. Ripley BD, Lissemore LI, Leishman PD et al. (2000) Pesticide residues on fruits and vegetables from Ontario, Canada, 1991-1995. J AOAC Int; 83: 196-213.
32. Saieva C, Aprea C, Tumino R et al. (2004) Twenty-four-hour urinary excretion of ten pesticide metabolites in healthy adults in two different areas of Italy (Florence and Ragusa). Sci Total Environ; 332: 71-80.
33. Samuel O, St-Laurent L, Dumas P et al. (2002) Pesticides en milieu serricole - Caractérisation de l'exposition des travailleurs et évaluation des délais de réentrée. Report no. R315. Quebec, Canada: Institut de recherche Robert-Sauvé en santé et sécurité au travail (IRSST).
34. Sidell FR. (1994) Clinical effects of organophosphorus cholinesterases inhibitors. J Appl Toxicol; 14: 111-3.
35. Simcox N, Fenske RA, Wolz SA et al. (1995) Pesticides in household dust and soil: Exposure pathways for children of agricultural families. Environ Health Perspect; 103: 1126-34.
36. Tuomainen A, Kangas JA, Meuling WJA et al. (2002) Monitoring of pesticide applicators for potential dermal exposure to malathion and biomarkers in urine. Toxicol Lett; 134: 125-32.
37. Yokley RA, Shen N, Cheung MW. (2000) Determination of two oxy-pyrimidine metabolites of diazinon in urine by gas chromatography/mass selective detection and liquid chromatography/electrospray ionization/mass spectrometry/ mass spectrometry. J AOAC Int; 83: 1229-38.