A responsive MRI contrast agent to monitor functional cell status

NeuroImage

Volumn 32, Issue 3, 2006, Pages 1142-1149

  Himmelreich, U ^a   Aime, S ^b   Hieronymus, T ^c   Justicia, C ^a   Uggeri, F ^d   Zenke, M ^c   Hoehn, M ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b UNIVERSITY OF TURIN   (Italy)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d Bracco Imaging SpA   (Italy)

Author keywords

Conditional activation; Dendritic cells; Magnetic resonance imaging; Molecular imaging; Responsive contrast agents; Stem cells

Indexed keywords

GADOLINIUM;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CHELATION; CONTROLLED STUDY; DENDRITIC CELL; ENZYME ACTIVATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL;

ANIMALS; BONE MARROW CELLS; BRAIN; CELL PHYSIOLOGY; CELL TRANSPLANTATION; CONTRAST MEDIA; DENDRITIC CELLS; DNA, COMPLEMENTARY; GADOLINIUM DTPA; GENE EXPRESSION PROFILING; LIPASE; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED C57BL; MODELS, ANATOMIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, WISTAR; RNA, COMPLEMENTARY; STEM CELLS;

EID: 33748090929     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2006.05.009     Document Type: Article

References (25)

1. Ahrens E.T., Feili-Hariri M., Xu H., Genove G., and Morel P.A. Receptor-mediated endocytosis of iron-oxide particles provides efficient labeling of dendritic cells for in vivo MR imaging. Magn. Reson. Med. 49 (2003) 1006-1013
2. Aime S., Cabella C., Colombatto S., Crich S.G., Gianolio E., and Maggioni F. Insight into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations. J. Magn. Reson. Imag. 16 (2002) 394-406
3. Anelli, P., Lattuada, L., Uggeri, F., Lux, G., Serleti, M., Gabellini, M., Tournier, H., 2000. Amphipatic Polycarboxylic Chelates and Complexes with Paramagnetic Metals as MRI Contrast Agents. Patent WO 00/30688.
4. Banchereau J., and Steinman R.M. Dendritic cells and the control of immunity. Nature 392 (1998) 245-252
5. Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y.J., Pulendran B., and Palucka K. Immunobiology of dendritic cells. Ann. Rev. Immunol. 18 (2000) 767-811
6. Bulte J.W.M., Douglas T., Witwer B., Zhang S.C., Strable E., Lewis B.K., Zywicke H., Miller B., van Gelderen P., Moskowitz B.M., Duncan I.D., and Frank J.A. Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat. Biotechnol. 19 (2001) 1141-1147
7. Crich S.G., Biancone L., Cantaluppi V., Duo D., Esposito G., Russo S., Camussi G., and Aime S. Improved route for visualization of stem cells labeled with a Gd-/Eu-chelate as a dual (MRI and fluorescence) agent. Magn. Reson. Med. 51 (2004) 938-944
8. de Vries I.J.M., Lesterhuis W.J.L., Barentsz J.O., Verdijk P., van Krieken J.H., Boerman O.C., Oyen W.J.G., Bonenkamp J.J., Boezeman J.B., Adema G.J., Bulte J.W.M., Scheenen T.W.J., Punt C.J.A., Heerschap A., and Figdor C.G. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat. Biotechnol. 23 (2005) 1407-1413
9. Donahue K.M., Burstein D., Manning W.J., and Gray M.L. Studies of Gd-DTPA relaxivity and proton exchange rates in tissue. Magn. Reson. Med. 32 (1994) 66-76
10. Fischer M., Goldschmitt J., Peschel C., Brakenhoff J.P., Kallen K.J., Wollmer A., Grotzinger J., and Rose-John S. A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat. Biotechnol. 15 (1997) 142
11. Hacker C., Kirsch R.D., Ju X.S., Hieronymus T., Gust T.C., Kuhl C., Jorgas T., Kurz S.M., Rose-John S., Yokota Y., and Zenke M. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat. Immunol. 4 (2003) 380-386
12. Hieronymus T., Gust T.C., Kirsch R.D., Jorgas T., Blendinger G., Goncharenko M., Supplitt K., Rose-John S., Muller A.M., and Zenke M. Progressive and controlled development of mouse dendritic cells from Flt(3+)CD11b(+) progenitors in vitro. J. Immunol. 174 (2005) 2552-2562
13. Hoehn M., Küstermann E., Blunk J., Wiedermann D., Trapp T., Wecker S., Föcking M., Arnold H., Heschler J., Fleischmann B.K., Schwindt C., and Bührle C. Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat. Proc. Natl. Acad. Sci. 99 (2002) 16267-16272
14. Koenig S.H., and Brown R.D.I. Relaxometry of tissue. In: Gupta R.K. (Ed). NMR spectroscopy of cells and organisms vol. 2 (1987), CRC Press, Boca Raton 75-114
15. Lewin M., Clement O., Belguise-Valladier P., Tran L., Cuenod C.A., Siauve N., and Frija G. Hepatocte targeting with Gd-EOB-DTPA. Potential application for gene therapy. Invest. Radiol. 36 (2001) 9-14
16. Louie A.Y., Hüber M.M., Ahrens E.T., Rothbächer U., Moats R., Jacobs R.E., Fraser S.E., and Meade T.J. In vivo visualization of gene expression using magnetic resonance imaging. Nat. Biotechnol. 18 (2000) 321-325
17. Merisko-Liversidge E., Liversidge G.G., and Cooper E.R. Nanosizing: a formulation approach for poorly-water-soluble compounds. Pharm. Sci. 18 (2003) 113-120
18. Moats R.A., Fraser S.E., and Meade T.J. A smart magnetic resonance imaging agent that reports on specific enzymatic activity. Angew. Chem., Int. Ed. 36 (1997) 726-728
19. Modo M., Cash D., Mellodew K., Williams S.C.R., Fraser S.E., Meade T.J., Price J., and Hodges H. Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging. NeuroImage 17 (2002) 803-811
20. Modo M., Mellodew K., Cash D., Fraser S.E., Meade T.J., Price J., and Williams S.C.R. Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging study. NeuroImage 21 (2004) 311-317
21. Okabe M., Ikawa M., Kominami K., Nakanishi T., and Nishimune Y. Green mice as a source of ubiquitous green cells. FEBS Lett. 407 (1997) 313-319
22. Stanisz G.J., and Henkelman R.M. Gd-DTPA relaxivity depends on macromolecular content. Magn. Reson. Med. 44 (2000) 665-667
23. Terreno E., Geninatti Grich S., Belfiore S., Biancone L., Cabella C., Esposito G., Manazza A., and Aime S. Effect of the intracellular localization of a Gd-based imaging probe on the relaxation enhancement of water protons. Proc. Int. Soc. Magn. Reson. Med. 13 (2005) 2622
24. Terreno E., Geninatti Crich S., Belfiore S., Biancone L., Cabella C., Esposito G., Manazza A.D., and Aime S. Effect of the intracellular localization of a Gd-based imaging probe on the relaxation enhancement of water protons. Magn. Reson. Med. 55 (2006) 491-497
25. Zenke M., and Hieronymus T. Towards an understanding of the transcription factor network of dendritic cell development. Trends Immunol. 27 (2006) 140-145