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Asymmetric synthesis of 1 by use of chiral pool and chiral auxiliary approaches:. Chambers M.S., and Thomas E.J. J. Chem. Soc., Chem. Commun. (1989) 23-24
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Synthesis of chiral analogues from naturally occurring 1:. Sakya S.M., Suarez-Contreras M., Dirlam J.P., O'Connell T.N., Hayashi S.F., Santoro S.L., Kamicker B.J., George D.M., and Ziegler C.B. Bioorg. Med. Chem. Lett. 11 (2001) 2751-2754
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17
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30444441272
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Kim P., Zhang Y.-M., Shenoy G., Nguyen Q.-A., Boshoff H.I., Manjunatha U.H., Goodwin M.B., Lonsdale J., Price A.C., Miller D.J., Duncan K., White S.W., Rock C.O., Barry III C.E., and Dowd C.S. J. Med. Chem. 49 (2006) 159-171
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18
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0842283488
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Racemic analogues of 1 as potential antimalarial agents:
-
Racemic analogues of 1 as potential antimalarial agents:. Jones S.M., Urch J.E., Brun R., Harwood J.L., Berry C., and Gilbert I.H. Bioorg. Med. Chem. 12 (2004) 683-692
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0034176221
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Racemic analogues of 1 as other bioactive agents:. Jones A.L., Herbert D., Rutter A.J., Dancer J.E., and Harwood J.L. Biochem. J. 347 (2000) 205-209
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Jones, A.L.1
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Kremer L., Douglas J.D., Baulard A.R., Morehouse C., Guy M.R., Alland D., Dover L.G., Lakey J.H., Jacobs Jr. W.R., Brennan P.J., Minnikin D.E., and Besra G.S. J. Biol. Chem. 275 (2000) 16857-16864
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Senior S.J., Illarionov P.A., Gurcha S.S., Campbell I.B., Schaeffer M.L., Minnikin D.E., and Besra G.S. Bioorg. Med. Chem. Lett. 13 (2003) 3685-3688
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0346729872
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Senior S.J., Illarionov P.A., Gurcha S.S., Campbell I.B., Schaeffer M.L., Minnikin D.E., and Besra G.S. Bioorg. Med. Chem. Lett. 14 (2004) 373-376
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15044344526
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Kamal A., Shaik Ahmad A., Sinha R., Yadav J.S., and Arora Sudarshan K. Bioorg. Med. Chem. Lett. 15 (2005) 1927-1929
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26
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1342310666
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The methylation was performed using the tetrabutylammonium salt of 6 after recrystallization from AcOEt. If not, chemoselectivity was decreased
-
Shenoy G., Kim P., Goodwin M., Nguyen Q.-A., Barry C.E., and Dowd C.S. Heterocycles 63 (2004) 519-527 The methylation was performed using the tetrabutylammonium salt of 6 after recrystallization from AcOEt. If not, chemoselectivity was decreased
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Heterocycles
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Shenoy, G.1
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Dowd, C.S.6
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28
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33747880590
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note
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®-L2-catalyzed kinetic resolution of the tetronic acid 17 gave the corresponding (S)-acetate in 59% yield with 31% ee along with the recovered (R)-alcohol 17 in 26% yield with 78% ee.
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