Biochemical Pathways of Wound Healing: Implications for Development of Disease-Specific Diagnostics

Advances in Clinical Chemistry

Volumn 41, Issue , 2006, Pages 167-187

  Menke, Nathan B ^a   Diegelmann, Robert F ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33747871931     PISSN: 00652423     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2423(05)41005-7     Document Type: Review

References (36)

1. Lazarus G., Cooper D., Knighton D., et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Arch Dermatol 130 4 (1994) 489-493
2. Clark R. Fibrin and wound healing. Ann NY Acad Sci 936 (2001) 355-367
3. Weiss S. Tissue destruction by neutrophils. N Engl J Med 320 6 (1989) 365-376
4. Nwomeh B., Liang H., Diegelmann R., Cohen I., and Yager D. Dynamics of the matrix metalloproteinases MMP-1 and MMP-8 in acute open human dermal wounds. Wound Repair Regen 6 2 (1998) 127-134
5. Nwomeh B., Liang H., Cohen I., and Yager D. MMP-8 is the predominant collagenase in healing wounds and nonhealing ulcers. J Surg Res 81 2 (1999) 189-195
6. Diegelmann R., Cohen I., and Kaplan A. The role of macrophages in wound repair: A review. Plast Reconstr Surg 68 1 (1981) 107-113
7. Witte M., and Barbul A. General principles of wound healing. Surg Clin North Am 77 3 (1997) 509-528
8. Lawrence W. Physiology of the acute wound. Clin Plast Surg 25 3 (1998) 321-340
9. Laurent T., Laurent U., and Fraser J. The structure and function of hyaluronan: An overview. Immunol Cell Biol 74 2 (1996) A1-A7
10. Terranova V., Aumailley M., Sultan L., Martin G., and Kleinman H. Regulation of cell attachment and cell number by fibronectin and laminin. J Cell Physiol 127 3 (1986) 473-479
11. Kirsner R., and Eaglstein W. The wound healing process. Dermatol Clin 11 4 (1993) 629-640
12. O'Toole E. Extracellular matrix and keratinocyte migration. Clin Exp Dermatol 26 6 (2001) 525-530
13. Clark R. Biology of dermal wound repair. Dermatol Clin 11 4 (1993) 647-666
14. Nwomeh B., Yager D., and Cohen I. Physiology of the chronic wound. Clin Plast Surg 25 3 (1998) 341-356
15. Falanga V., Grinnell F., Gilchrest B., Maddox Y., and Moshell A. Workshop on the pathogenesis of chronic wounds. J Invest Dermatol 102 1 (1994) 125-127
16. Falanga V. Wound healing and chronic wounds. J Cutan Med Surg 3 Suppl 1 (1998) 1-5 S1-
17. Palolahti M., Lauharanta J., Stephens R., Kuusela P., and Vaheri A. Proteolytic activity in leg ulcer exudate. Exp Dermatol 2 1 (1993) 29-37
18. Diegelmann R. Excessive neutrophils characterize chronic pressure ulcers. Wound Repair Regen 11 6 (2003) 490-495
19. Yager D., Zhang L., Liang H., Diegelmann R., and Cohen I. Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids. J Invest Dermatol 107 5 (1996) 743-748
20. Wysocki A., Kusakabe A., Chang S., and Tuan T. Temporal expression of urokinase plasminogen activator, plasminogen activator inhibitor and gelatinase-B in chronic wound fluid switches from a chronic to acute wound profile with progression to healing. Wound Repair Regen 7 3 (1999) 154-165
21. Wysocki A. Wound fluids and the pathogenesis of chronic wounds. J Wound Ostomy Continence Nurs 23 6 (1996) 283-290
22. Wysocki A., Staiano-Coico L., and Grinnell F. Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. J Invest Dermatol 101 1 (1993) 64-68
23. Rao C., Ladin D., Liu Y., Chilukuri K., Hou Z., and Woodley D. Alpha 1-antitrypsin is degraded and non-functional in chronic wounds but intact and functional in acute wounds: The inhibitor protects fibronectin from degradation by chronic wound fluid enzymes. J Invest Dermatol 105 4 (1995) 572-578
24. Grinnell F., and Zhu M. Fibronectin degradation in chronic wounds depends on the relative levels of elastase, alpha1-proteinase inhibitor, and alpha 2-macroglobulin. J Invest Dermatol 106 2 (1996) 335-341
25. Yager D., Chen S., Ward S., Olutoye O., Diegelmann R., and Cohen I. The ability of chronic wound fluids to degrade peptide growth factors is associated with increased levels of elastase activity and diminished levels of proteinase inhibitors. Wound Repair Regen 5 (1997) 23-32
26. Suomalainen K., Halinen S., Ingman T., et al. Tetracycline inhibition identifies the cellular sources of collagenase in gingival crevicular fluid in different forms of periodontal diseases. Drugs Exp Clin Res 18 3 (1992) 99-104
27. Thompson R., and Baxter B. MMP inhibition in abdominal aortic aneurysms. Rationale for a prospective randomized clinical trial. Ann N Y Acad Sci 878 (1999) 159-178
28. Curci J., Petrinec D., Liao S., Golub L., and Thompson R. Pharmacologic suppression of experimental abdominal aortic aneurysms: A comparison of doxycycline and four chemically modified tetracyclines. J Vasc Surg 28 6 (1998) 1082-1093
29. Greenwald R., Moak S., Ramamurthy N., and Golub L. Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage. J Rheumatol 19 6 (1992) 927-938
30. Uitto J., Perejda A., Grant G., Rowold E., Kilo C., and Williamson J. Glycosylation of human glomerular basement membrane collagen: Increased content of hexose in ketoamine linkage and unaltered hydroxylysine-O-glycosides in patients with diabetes. Connect Tissue Res 10 3/4 (1982) 287-296
31. Pinzur M., Slovenkai M., Trepman E., and Shields N. Guidelines for diabetic foot care: Recommendations endorsed by the Diabetes Committee of the American Orthopaedic Foot and Ankle Society. Foot Ankle Int 26 1 (2005) 113-119
32. Cowin A., Hatzirodos N., Holding C., et al. Effect of healing on the expression of transforming growth factor beta(s) and their receptors in chronic venous leg ulcers. J Invest Dermatol 117 5 (2001) 1282-1289
33. Puxeddu I., Piliponsky A., Bachelet I., and Levi-Schaffer F. Mast cells in allergy and beyond. Int J Biochem Cell Biol 35 12 (2003) 1601-1607
34. Kofford M., Schwartz L., Schechter N., Yager D., Diegelmann R., and Graham M. Cleavage of type I procollagen by human mast cell chymase initiates collagen fibril formation and generates a unique carboxyl-terminal propeptide. J Biol Chem 272 11 (1997) 7127-7131
35. Lim I., Phan T., Tan E., et al. Synchronous activation of ERK and phosphatidylinositol 3-kinase pathways is required for collagen and extracellular matrix production in keloids. J Biol Chem 278 42 (2003) 40851-40858
36. Diegelmann R., and Evans M. Wound healing: An overview of acute, fibrotic and delayed healing. Front Biosci 9 (2004) 283-289