Expression of β-defensins pBD-1 and pBD-2 along the small intestinal tract of the pig: Lack of upregulation in vivo upon Salmonella typhimurium infection

Molecular Immunology

Volumn 44, Issue 4, 2007, Pages 276-283

  Veldhuizen, Edwin J A ^a   van Dijk, Albert ^a   Tersteeg, Monique H G ^b   Kalkhove, Stefanie I C ^a   van der Meulen, Jan ^c   Niewold, Theo A ^c   Haagsman, Henk P ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Defensin; Innate immunity; Porcine defensins 1 and 2; Salmonella typhimurium; Small intestinal segment perfusion

Indexed keywords

BETA DEFENSIN 1; BETA DEFENSIN 2; MESSENGER RNA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; ILEUM; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTESTINE MUCOSA; INTESTINE PERFUSION; JEJUNUM; KIDNEY; LIVER; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLA TYPHIMURIUM; SALMONELLOSIS; SMALL INTESTINE; SWINE; TONGUE; UPREGULATION;

ANIMALS; BETA-DEFENSINS; GENE EXPRESSION REGULATION; INTESTINE, SMALL; ORGAN SPECIFICITY; RNA, MESSENGER; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM; SWINE;

SALMONELLA; SALMONELLA TYPHIMURIUM; SUIDAE; SUS SCROFA;

EID: 33747856153     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.03.005     Document Type: Article

References (38)

1. Akkina J.E., Hogue A.T., Angulo F.J., Johnson R., Petersen K.E., Saini P.K., Fedorka-Cray P.J., and Schlosser W.D. Epidemiologic aspects, control, and importance of multiple-drug resistant Salmonella typhimurium DT104 in the United States. J. Am. Vet. Med. Assoc. 214 (1999) 790-798
2. Caverly J.M., Diamond G., Gallup J.M., Brogden K.A., Dixon R.A., and Ackermann M.R. Coordinated expression of tracheal antimicrobial peptide and inflammatory-response elements in the lungs of neonatal calves with acute bacterial pneumonia. Infect. Immun. 71 (2003) 2950-2955
3. Conejo-Garcia J.R., Benencia F., Courreges M.C., Kang E., Mohamed-Hadley A., Buckanovich R.J., Holtz D.O., Jenkins A., Na H., Zhang L., Wagner D.S., Katsaros D., Caroll R., and Coukos G. Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A. Nat. Med. 10 (2004) 950-958
4. Darwin K.H., and Miller V.L. Molecular basis of the interaction of Salmonella with the intestinal mucosa. Clin. Microbiol. Rev. 12 (1999) 405-428
5. Diamond G., Russell J.P., and Bevins C.L. Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 5156-5160
6. Drury R.A.B., and Wallington E.A. Carlton's Histological Technique (1980), Oxford University Press, Oxford
7. Finlay B.B., and Hancock R.E. Can innate immunity be enhanced to treat microbial infections?. Nat. Rev. Microbiol. 2 (2004) 497-504
8. Giulietti A., Overbergh L., Valckx D., Decallonne B., Bouillon R., and Mathieu C. An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods 25 (2001) 386-401
9. Harder J., Bartels J., Christophers E., and Schröder J.M. Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276 (2001) 5707-5713
10. Hendriksen S.W., Orsel K., Wagenaar J.A., Miko A., and van Duijkeren E. Animal-to-human transmission of Salmonella typhimurium DT104A variant. Emerg. Infect. Dis. 10 (2004) 2225-2227
11. Li J., Post M., Volk R., Gao Y., Li M., Metais C., Sato K., Tsai J., Aird W., Rosenberg R.D., Hampton T.G., Li J., Sellke F., Carmeliet P., and Simons M. PR39, a peptide regulator of angiogenesis. Nat. Med. 6 (2000) 49-55
12. Liu F., Abiko Y., Nishimura M., Kusano K., Shi S., Kaku T., and Lin F. Expression of inflammatory cytokines and beta-defensin 1 mRNAs in porcine epithelial rests of Malassez in vitro. Med. Electron. Microsc. 34 (2001) 174-178
13. Liu L., Wang L., Jia H.P., Zhao C., Heng H.H., Schutte B.C., McCray Jr. P.B., and Ganz T. Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. Gene 222 (1998) 237-244
14. Meyerholz D.K., Gallup J.M., Grubor B.M., Evans R.B., Tack B.F., McCray Jr. P.B., and Ackermann M.R. Developmental expression and distribution of sheep beta-defensin-2. Dev. Comp. Immunol. 28 (2004) 171-178
15. Mygind P.H., Fischer R.L., Schnorr K.M., Hansen M.T., Sönksen C.P., Ludvigsen S., Raventós D., Buskov S., Christensen B., De Maria L., Taboureau O., Yaver D., Elvig-Jørgensen S.G., Sørensen M.V., Christensen B.E., Kjærulff S., Frimodt-Moller N., Lehrer R.I., Zasloff M., and Kristensen H.H. Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus. Nature 437 (2005) 975-980
16. Nabuurs M.J., Hoogendoorn A., van Zijderveld F.G., and van der Klis J.D. A long-term perfusion test to measure net absorption in the small intestine of weaned pigs. Res. Vet. Sci. 55 (1993) 108-114
17. Niewold T.A., Kerstens H.H., van der Meulen J., Smits M.A., and Hulst M.M. Development of a porcine small intestinal cDNA micro-array: characterization and functional analysis of the response to enterotoxigenic E. coli. Vet. Immunol. Immunopathol. 105 (2005) 317-329
18. Niyonsaba F., Iwabuchi K., Matsuda H., Ogawa H., and Nagaoka I. Epithelial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway. Int. Immunol. 14 (2002) 421-426
19. Niyonsaba F., Someya A., Hirata M., Ogawa H., and Nagaoka I. Evaluation of the effects of peptide antibiotics human beta-defensins-1/2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. Eur. J. Immunol. 31 (2001) 1066-1075
20. Ogushi K., Wada A., Niidome T., Mori N., Oishi K., Nagatake T., Takahashi A., Asakura H., Makino S., Hojo H., Nakahara Y., Ohsaki M., Hatakeyama T., Aoyagi H., Kurazono H., Moss J., and Hirayama T. Salmonella enteritidis FliC (flagella filament protein) induces human beta-defensin-2 mRNA production by Caco-2 cells. J. Biol. Chem. 276 (2001) 30521-30526
21. Oleksiewicz M.B., Donaldson A.I., and Alexandersen S. Development of a novel real-time RT-PCR assay for quantitation of foot-and-mouth disease virus in diverse porcine tissues. J. Virol. Methods 92 (2001) 23-35
22. O'Neil D.A., Porter E.M., Elewaut D., Anderson G.M., Eckmann L., Ganz T., and Kagnoff M.F. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J. Immunol. 163 (1999) 6718-6724
23. Sang Y., Ramanathan B., Ross C.R., and Blecha F. Gene silencing and overexpression of porcine peptidoglycan recognition protein long isoforms: involvement in beta-defensin-1 expression. Infect. Immun. 73 (2005) 7133-7141
24. Shi J., Zhang G., Wu H., Ross C., Blecha F., and Ganz T. Porcine epithelial beta-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations. Infect. Immun. 67 (1999) 3121-3127
25. Stolzenberg E.D., Anderson G.M., Ackermann M.R., Whitlock R.H., and Zasloff M. Epithelial antibiotic induced in states of disease. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 8686-8690
26. Tarver A.P., Clark D.P., Diamond G., Russell J.P., Erdjument-Bromage H., Tempst P., Cohen K.S., Jones D.E., Sweeney R.W., Wines M., Hwang S., and Bevins C.L. Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection. Infect. Immun. 66 (1998) 1045-1056
27. Territo M.C., Ganz T., Selsted M.E., and Lehrer R. Monocyte-chemotactic activity of defensins from human neutrophils. J. Clin. Invest. 84 (1989) 2017-2020
28. Tersteeg M.H., Koolmees P.A., and van Knapen F. Immunohistochemical detection of brain tissue in heated meat products. Meat Sci. 61 (2002) 67-72
29. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., and Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3 (2002) 0034.1-0034.11
30. Wehkamp J., Fellermann K., Herrlinger K.R., Bevins C.L., and Stange E.F. Mechanisms of disease: defensins in gastrointestinal diseases. Nat. Clin. Pract. Gastroenterol. Hepatol. 2 (2005) 406-415
31. Wehkamp J., Salzman N.H., Porter E., Nuding S., Weichenthal M., Petras R.E., Shen B., Schaeffeler E., Schwab M., Linzmeier R., Feathers R.W., Chu H., Lima Jr. H., Fellermann K., Ganz T., Stange E.F., and Bevins C.L. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 18129-18134
32. Wernersson R., Schierup M.H., Jørgensen F.G., Gorodkin J., Panitz F., Stærfeldt H.H., Christensen O.F., Mailund T., Hornshøj H., Klein A., Wang J., Liu B., Hu S., Dong W., Li W., Wong G.K., Yu J., Wang J., Bendixen C., Fredholm M., Brunak S., Yang H., and Bolund L. Pigs in sequence space: a 0.66X coverage pig genome survey based on shotgun sequencing. BMC Genomics 6 (2005) 70
33. Wong M.L., and Medrano J.F. Real-time PCR for mRNA quantitation. Biotechniques 39 (2005) 75-85
34. Xu J., and Gordon J.I. Inaugural article: honor thy symbionts. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 10452-10459
35. Yang D., Chen Q., Chertov O., and Oppenheim J.J. Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells. J. Leukoc. Biol. 68 (2000) 9-14
36. Zhang G., Hiraiwa H., Yasue H., Wu H., Ross C.R., Troyer D., and Blecha F. Cloning and characterization of the gene for a new epithelial beta-defensin. Genomic structure, chromosomal localization, and evidence for its constitutive expression. J. Biol. Chem. 274 (1999) 24031-24037
37. Zhang G., Wu H., Shi J., Ganz T., Ross C.R., and Blecha F. Molecular cloning and tissue expression of porcine beta-defensin-1. FEBS Lett. 424 (1998) 37-40
38. Zilbauer M., Dorrell N., Boughan P.K., Harris A., Wren B.W., Klein N.J., and Bajaj-Elliott M. Intestinal innate immunity to Campylobacter jejuni results in induction of bactericidal human beta-defensins 2 and 3. Infect. Immun. 73 (2005) 7281-7289