Development of a toxA gene knock-out mutant of Pasteurella multocida and evaluation of its protective effects

Journal of Microbiology

Volumn 44, Issue 3, 2006, Pages 320-326

  Kim, Tae Jung ^a   Lee, Jae Il ^b   Lee, Bong Joo ^b  

^a MURDOCH UNIVERSITY   (Australia)

^b Chonnam National University   (South Korea)

Author keywords

Homologous recombination; Knock out; Pasteurella multocida toxin (PMT); toxA

Indexed keywords

BACTERIA (MICROORGANISMS); PASTEURELLA MULTOCIDA;

BACTERIAL TOXIN; ENTEROTOXIN; TCDA PROTEIN, CLOSTRIDIUM DIFFICILE;

ANIMAL; ARTICLE; FEMALE; GENE DELETION; GENETIC RECOMBINATION; GENETICS; GRAM NEGATIVE INFECTION; IMMUNIZATION; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; MORTALITY; MOUSE; PASTEURELLA MULTOCIDA; PATHOGENICITY; VIRULENCE;

ANIMALS; BACTERIAL TOXINS; ENTEROTOXINS; FEMALE; GENE DELETION; IMMUNIZATION; MALE; MICE; MICE, INBRED ICR; PASTEURELLA INFECTIONS; PASTEURELLA MULTOCIDA; RECOMBINATION, GENETIC; VIRULENCE;

EID: 33747853893     PISSN: 12258873     EISSN: 12258873     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Adler, B., D. Bulach, J. Chung, S. Doughty, M. Hunt, K. Rajakumar, M. Serrano, A. van Zanden, Z. Yamei, and C. Ruffolo. 1999. Candidate vaccine antigens and genes in Pasteurella multocida. J. Biotechnol. 73, 83-90.
2. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. 1996. Current protocols in molecular biology. John Wiley and Sons Inc., NY.
3. Bagley, K.C., S.F. Abdelwahab, R.G. Tuskan, and G.K. Lewis. 2005. Pasteurella multocida toxin activates human monocyte-derived and murine bone marrow-derived dendritic cells in vitro but suppresses antibody production in vivo. Infect. Immun. 73, 413-421.
4. Busch, C., J. Orth, N. Djouder, and K. Aktories. 2001. Biological activity of a C-terminal fragment of Pasteurella multocida toxin. Infect. Immun. 69, 3628-3634.
5. Chanter, N., J.M. Rutter, and A. Mackenzie. 1986. Partial purification of an osteolytic toxin from Pasteurella multocida. J. Gen. Microbiol. 132, 1089-1097.
6. Ciprian, A., T.A. Cruz, and M. de la Garza. 1994. Mycoplasma hyopneumoniae: interaction with other agents in the pigs, and evaluation of immunogens. Arch. Med. Res. 25, 235-239.
7. Datsenko, K.A. and B.L. Wanner. 2000. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA 97, 6640-6645.
8. Davies, R.L., R. MacCorquodale, S. Baillie, and B. Caffrey. 2003. Characterization and comparison of Pasteurella multocida strains associated with porcine pneumonia and atrophic rhinitis. J. Med. Microbiol. 52, 59-67.
9. de Jong, M.F. 1999. Progressive and nonprogressive atrophic rhinitis, p. 355-384. In B. E. Straw, S. D'Allaire, W. L. Mengeling, and D. J. Taylor (eds.), Diseases of swine, 8th ed. Iowa State University Press, Ames, IA.
10. Haesebrouck, F., F. Pasmans, K. Chiers, D. Maes, R. Ducatelle, and A. Decostere. 2004. Efficacy of vaccines against bacterial diseases in swine: what can we expect? Vet. Microbiol. 100, 255-268.
11. Hodgson, J.C., A. Finucane, M.P. Dagleish, S. Ataei, R. Parton, and J.G. Coote. 2005. Efficacy of vaccination of calves against hemorrhagic septicemia with a live aroA derivative of Pasteurella multocida B:2 by two different routes of administration. Infect. Immun. 73, 1475-1481.
12. Hoskins, I.C., L.H., Thomas, and A.J. Lax. 1997. Nasal infection with Pasteurella multocidacauses proliferation of bladder epithelium in gnotobiotic pigs. Vet. Rec. 140, 22.
13. Hunt, M.L., B. Adler, and K.M. Townsend. 2000. The molecular biology of Pasteurella multocida. Vet. Microbiol. 72, 3-25.
14. Lax, A.J., and A.E. Grigoriadis. 2001. Pasteurella multocidatoxin: the mitogenic toxin that stimulates signalling cascades to regulate growth and differentiation. Int. J. Med. Microbiol. 291, 261-268.
15. Lax, A.J., G.D. Pullinger, M.R. Baldwin, D. Harmey, A.E. Grigoriadis, and J.H. Lakey. 2004. The Pasteurella multocida toxin interacts with signalling pathways to perturb cell growth and differentiation. Int. J. Med. Microbiol. 293, 505-512.
16. Lax, A.J., N. Chanter, G.D. Pullinger, T. Higgins, J.M. Staddon, and E. Rozengurt. 1990. Sequence analysis of the potent mitogenic toxin of Pasteurella multocida. FEBS Lett. 277, 59-64.
17. Lee, J.M., S.Y. Kang, S.I. Park, H.J. Woo, and M.S. Kwon. 2004. Molecular cloning and characterization of the gene for outer membrane protein H in a Pasteurella multocida (D:4) isolate from pigs with atrophic rhinitis symptoms in Korea. J. Microbiol. Biotechnol. 14, 1343-1349.
18. Lichtensteiger, C.A., S.M. Steenbergen, R.M. Lee, D.D. Poison, and E.R. Vimr. 1996. Direct PCR analysis for toxigenic Pasteurella multocida. J. Clin. Microbiol. 34, 3035-3039.
19. Mullan, P.B., and A.J. Lax. 1996. Pasteurella multocidatoxin is a mitogen for bone cells in primary culture. Infect. Immun. 64, 959-965.
20. Müller, G., H. Köhler, R. Diller, and W. Erler. 2001. Antibody reactions after aerogenous or subcutaneous immunization of pigs with Pasteurella multocida antigens. Vaccine 19, 751-757.
21. Nakai, T., A. Sawata, M. Tsuji, Y. Samejima, and K. Kume. 1984. Purification ofdermonecrotic toxin from a sonic extract of Pasteurella multocida SP-72 serotype D. Infect. Immun. 46, 429-434.
22. Oswald, E., J.P. Nougayrede, F. Taieb, and M. Sugai. 2005. Bacterial toxins that modulate host cell-cycle progression. Curr. Opin. Microbiol. 8, 83-91.
23. Petersen, S.K., and N.T. Foged. 1989. Cloning and expression of Pasteurella multocidatoxin gene, toxA, in Escherichia coli. Infect. Immun. 57, 3907-3913.
24. Pettit, R.K., M.R. Ackermann, and R.B. Rimler. 1993. Receptor-mediated binding of Pasteurella multocida dermonecrotic toxin to canine osteosarcoma and monkey kidney (vero) cells. Lab. Invest. 69, 94-100.
25. Pijoan, C. 1999. Pneumonic pasteurellosis, p. 511-520. In B. E. Straw, S. D'Allaire, W. L. Mengeling, and D. J. Taylor (eds.), Diseases of swine, 8th ed. Iowa State University Press, Ames, IA.
26. Pullinger, G.D., R. Sowdhamini, and A.J. Lax. 2001. Localization of functional domains of the mitogenic toxin of Pasteurella multocida. Infect. Immun. 69, 7839-7850.
27. Pullinger, G.D., T. Bevir, and A.J. Lax. 2004. The Pasteurella multocida toxin is encoded within a lysogenic bacteriophage. Mol. Microbiol. 51, 255-269.
28. Rajeev, S., R.V. Nair, S.A. Kania, and D.A. Bemis. 2003. Expression of a truncated Pasteurella multocida toxin antigen in Bordetella bronchiseptica. Vet. Microbiol. 94, 313-323.
29. Rozengurt, E., T. Higgins, N. Chanter, A.J. Lax, and J.M. Staddon. 1990. Pasteurella multocida toxin: potent mitogen for cultured fibroblasts. Proc. Natl. Acad. Sci. USA 87, 123-127.
30. Rutter, J.M., and A. Mackenzie. 1984. Pathogenesis of atrophic rhinitis in pigs, a new perspective. Vet. Rec. 114, 89-90.
31. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular cloning, a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
32. Smyth, M.G., I.G. Sumner, and A.J. Lax. 1999. Reduced pH causes structural changes in the potent mitogenic toxin of Pasteurella multocida. FEMS Microbiol. Lett. 180, 15-20.
33. Smyth, M.G., R.W. Pickersgill, and A.J. Lax. 1995. The potent mitogen Pasteurella multocidatoxin is highly resistant to proteolysis but becomes susceptible at lysosomal pH. FEBS Lett. 360, 62-66.
34. To, H., S. Someno, and S. Nagai. 2005. Development of a genetically modified nontoxigenic Pasteurella multocida toxin as a candidate for use in vaccines against progressive atrophic rhinitis in pigs. Am. J. Vet. Res. 66, 113-118.