Pasteurella multocida toxin is a mitogen for bone cells in primary culture

Infection and Immunity

Volumn 64, Issue 3, 1996, Pages 959-965

  Mullan, Paul B ^a   Lax, Alistair J ^a  

^a INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BACTERIAL TOXIN; COLLAGEN TYPE 1; CYCLIC AMP; DNA; INOSITOL PHOSPHATE; MITOGENIC AGENT; OSTEONECTIN;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHICK EMBRYO; CONTROLLED STUDY; DNA SYNTHESIS; EMBRYO; ENZYME ASSAY; HUMAN CELL; MITOGENESIS; NONHUMAN; OSTEOBLAST; OSTEOSARCOMA CELL; PASTEURELLA MULTOCIDA; PRIORITY JOURNAL;

EID: 0030021825     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.3.959-965.1996     Document Type: Article

References (54)

1. Bellows, C. G., J. E. Aubin, J. N. M. Heersche, and M. E. Antosz. 1986 Mineralized bone nodules, formed in vitro from enzymatically released rai calvarial cell populations Calcif. Tissue Int. 38:143-154.
2. Beresford, J. N., S. E. Graves, and C. A. Smoothy. 1993. Formation of mineralized nodules by bone derived cells in vitro: a model of bone formation Am. Med. Genet. 45:163-178.
3. 0-arrested fibroblasts and is post-transcriptionally regulated in response to growth factors. Nature (London) 317:443-445.
4. Bolander, M. E., P. Gehron-Robey, L. W. Fisher, K. M. Conn, B. S. Prabhaker, and J. D. Termine. 1989 Monoclonal antibodies against osteonectin show conservation of epitopes across species. Calcif. Tissue Int. 45:74-80.
5. Buys, W. E. C. M., H. E. Smith, A. M. I. E. Kamps, E. M. Kamp, and M. A. Smits. 1990. Sequence of the dermonecrotic toxin of Pasteurella multocida ssp. multocida. Nucleic Acids Res 18:2815-2816.
6. Canalis, E. 1985. Effect of growth factors on bone cell replication and differentiation. Clin. Orthop. Relat Res. 193:246-263.
7. Cantrella, M., T. L. McCarthy, and E. Canalis. 1989. Platelet derived growth factor enhances deoxyribonucleic acid and collagen synthesis in osteoblast-enriched cultures from fetal rat bone. Endocrinology 125:13-19
8. Caprioli, A., G. Donelli, V. Falbo, R. Possenti, L. G. Roda, G. Roscetti, and F. M. Ruggeri. 1984. A cell division-active protein from E. coli. Biochem Biopbys. Res. Commun 118:587-593.
9. Caprioli, A., V. Falbo, L. G. Roda, F. M. Ruggeri, and C. Zona. 1983. Partial purification and characterization of an Escherichia coli toxic factor that induces morphological cell alterations. Infect. Immun. 39:1300-1306
10. Chanter, N. 1990. Advances in atrophic rhinitis and toxigenic Pasteurella multocida research. Pig News Info. 11:503-506.
11. Cochran, B. H., J. Zullo, I. M. Verma, and C. D. Stiles. 1984. Expression of a c-fos gene and a fos-related gene is stimulated by platelet-derived growth factor Science (Washington, D.C.) 226:1080-1083.
12. De Rycke, J., E. A. Gonzalez, J. Blanco, E. Oswald, M. Blanco, and R. Boivin. 1990. Evidence for two types of cytotoxic necrotizing factor in human and animal clinical isolates of Escherichia coli. J. Clin. Microbiol. 28:694-699.
13. Dicker, P., and E. Rozengurt. 1980. Phorbol esters and vasopressin stimulate DNA synthesis by a common mechanism. Nature (London) 287:607-612.
14. Felix, R., H. Fleisch, and P. L. Frandsen. 1992. Effect of Pasteurella multocida toxin on bone resorption in vitro. Infect. Immun 60:4984-4988.
15. Gerstenfeld, L. C., S. D. Chipman, C. M. Kelly, K. J. Hodjens, P. Lee, and W. Landis. 1988. Collagen expression, ultra-structural assembly and mineralization in cultures of chicken embryo osteoblasts. J. Cell Biol. 106:979-989.
16. Globus, R., J. Plonet, and D. Gospodarowicz. 1988. Cultured bovine cells synthesize fibroblast growth factor and store it in their extracellular matrix. Endocrinology 124:1539-1547
17. Hata, R., H. Hori, Y. Nagay, S. Tanaka, M. Kondo, M. Hiramatsu, N. Utsumi, and M. Kumegawa. 1984 Selective inhibition of type 1 collagen synthesis in osteoblastic cells by epidermal growth factor. Endocrinology 115:867-876
18. Higgins, T. E., A. C. Murphy, J. M. Staddon, and A. J. Lax. 1992. Pasteurella multocida toxin is a potent inducer of anchorage-independent cell growth. Proc. Natl. Acad. Sci. USA 89:4240-4244
19. Horowitz, M. C. 1993. Cytokines and estrogen in bone: anti-osteoporotic effects Science (Washington, D.C.) 260:626-627.
20. Il'ina, Z. M., and M. I. Zasukhin. 1975. Role of Pasteurella toxins in the pathogenesis of infectious atrophic rhinitis. Sb Nauchn. Rab. Sib. Nauchno-Issled Vet Inst. 25:76-86.
21. Jongen, J. W. J. M., E. C. Willemsteinvanhove, J. M. Vandermeer, M. P. Bos, H. Juppner, G. V. Serge, A. B. Abousamra, J. H. M. Feyen, and M. P. M. Herrmannerlee. 1995. Down regulation of the receptor for PTH and PTH-rP by TGF-β in primary foetal-rat osteoblasts. Endocrinology 136:3260-3266.
22. Kimman, T. G., C. W. G. M. Lowik, L. J. A. Van De Wee-Pals, C. W. Thesingh, P. Defize, E. M. Kamp, and O. L. M. Bijvoet. 1987. Stimulation of bone resorption by inflamed nasal mucosa. dermonecrotic toxin-containing conditioned medium from Pasteurella multocida and purified dermonecrotic toxin from P multocida. Infect. Immun. 55:2110-2116.
23. Laemmli, U. K. 1970. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
24. Lax, A. J., and N. Chanter. 1990. Cloning of the toxin gene from Pasteurella multocida and its role in atrophic rhinitis. J. Gen. Microbiol. 136:81-87.
25. Lax, A. J., N. Chanter, G. D. Pullinger, T. Higgins, J. M. Staddon, and E. Rozengurt. 1990. Sequence analysis of the potent mitogenic toxin of Pasteurella multocida. FEBS Lett 277:59-64.
26. McCanley, L. K., A. J. Koh, C. A. Beecher, V. Q. Cui, J. D. Decker, and R. T. Francheschi. 1995. Effects of differentiation and transforming growth-factor beta (1) on PTH/PTHTRP receptor messenger RNA levels in MC3T3-E1 cells. J. Bone Miner. Res. 10:1243-1255.
27. McGee-Russell, S. M. 1958. Histochemical methods for calcium. J. Histochem. Cytochem. 6:22
28. Meikle, M. C., S. Bord, R. M. Hembry, J. Compston, P. I. Croucher, and J. J. Reynolds. 1992. Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines. J. Cell Sci 103:1093-1099.
29. Michaelangeli, V. P., D. M. Findlay, A. Fletcher, and T. J. Martin. 1986. Calcitonin gene-related peptide (cGRP) acts independently of calcitonin on cAMP formation in clonal osteogenic-sarcoma cells (UMR-106-01) Calcif. Tissue Int. 39:44-48.
30. Murphy, A. C., and E. Rozengurt. 1992. Pasteurella multocida toxin selectively facilitates phosphatidylinositol 4,5-bisphosphate hydrolysis by born-besin, vasopressin and endothelin J. Biol. Chem. 267:25296-25303.
31. Nanberg, E., and E. Rozengurt. 1988. Temporal relationship between inositol polyphosphate formation and increases in cytosolic calcium in quiescent 3T3 cells stimulated by PDGF, bombesin and vasopressin EMBO J. 7:2741-2748.
32. Nicolas, V., J. R. Nefussi, P. Colln, and N. Forest. 1990. Effects of acidic fibroblast growth factor and epidermal growth factor on subconfluent fetal rat calvarial cell cultures: DNA synthesis and alkaline phosphatase activity. Bone Miner. 8:145-156
33. Nijweide, P. J., A. Van der Plas, and J. P. Scherft. 1981. Biochemical and histochemical studies on various bone cell preparations. Calcif. Tissue Int. 33:529-540.
34. Oswald, E., and J. De Rycke. 1990. A single protein of 110kDa is associated with the multinucleating and necrotizing activity coded by the Vir plasmid of Escherichia coli. FEMS Microbiol. Lett. 68:279-284.
35. Oswald, E., M. Sugai, A. Labigne, H. C. Wu, C. Fiorentini, P. Boquet, and A. D. O'Brien. 1994. Cytotoxic necrotizing factor type 2 produced by virulent E. coli modifies the small GTP-binding proteins Rho involved in assembly of actin stress fibres Proc. Natl. Acad. Sci. USA 91:3814-3818
36. Page, K. M. 1982. Bone and the preparation of bone sections. p. 324-325 In J. D. Bancroft and A. Stevens (ed.). In Theory and practice of histological techniques, 2nd ed. Churchill Livingstone Inc., New York.
37. Perry, H. M., W. Skogen, J. Chappel, A. J. Kahn, G. Wilner, and S. L. Teitelbaum. 1989. Partial characterisation of a parathyroid hormone-stimulated resorption factor(s) from osteoblast-like cells. Endocrinology 125:2076-2079.
38. Petersen, S. K. 1990. The complete nucleotide sequence of the Pasteurella multocida toxin gene and evidence for a transcriptional repressor, TxaR. Mol. Microbiol. 4:821-830.
39. Raisz, L. G. 1988. Hormonal-regulation of bone growth and remodeling Ciba Found. Symp. 136:226-238.
40. Rodan, G. A., and S. B. Rodan. 1984 Expression of the osteoblast phenotype, p. 244-285. In W. A. Peck (ed.). Bone and mineral research 2 Elsevier Science Publishing, Amsterdam.
41. Rozengurt, E. 1986. Early signals in the mitogenic response. Science 234:161-166.
42. Rozengurt, E., T. Higgins, N. Chanter, A. J. Lax, and J. M. Staddon. 1990. Pasteurella multocida toxin: potent mitogen for cultured fibroblasts. Proc. Natl. Acad. Sci. USA 87:123-127.
43. Rozengurt, E., and J. Sinnett-Smith. 1983. Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 fibroblasts. Proc Natl. Acad. Sci. USA 80:2936-2940
44. Scutt, A., H. Mayer, and E. Wingender. 1992. New perspectives in the differentiation of bone-forming cells. Biofactors 4:1-13.
45. Simmons, P. J., G. N. Kent, R. L. Jilka, P. M. Scott, M. Fallon, and P. V. Kohn. 1982. Formation of bone by isolated, cultured osteoblasts in millipore diffusion chambers. Calcif. Tissue Int. 34:291-294.
46. Staddon, J. M., N. Chanter, A. J. Lax, T. E. Higgins, and E. Rozengurt. 1990. Pasteurella multocida toxin, a potent milogen. stimulates protein kinase C-dependent and -independent protein phosphorylation in Swiss 3T3 cells. J. Biol. Chem. 265:11841-11848.
47. Stavric, S., J. I. Spiers, J. Konowalchuk, and D. Jeffrey. 1978. Stimulation of cyclic AMP secretion in Vero cells by enterotoxins of Escherichia coli and Vibrio cholerae. Infect Immun. 21:514-517.
48. Termine, J. D., H. K. Kleinman, S. W. Whitson, K. M. Conn, M. L. McGarvey, and G. R. Martin. 1981. Osteonectin, a bone-specific protein linking mineral to collagen. Cell 26:99-105
49. 2 receptors mediating adenylate cyclase and phospholipase C pathways in osteoblastic clone MC3T3-E1. Prostaglandins Leukot. Essent. Fatty Acids 46:15-20.
50. Van Diemen, P. M., G. de Vries Reilingh, and H. K. Parmentier. 1994. Immune responses of piglets to Pasteurella multocida toxin and toxoid Vet Immunol. Immunopathol. 41:307-321.
51. Walker, K. E., and A. A. Weiss. 1994. Characterization of the dermonecrotic toxin in members of the genus Bordetella. Infect. Immun 62:3817-3828
52. Ward, P. N., T. E. Higgins, A. C. Murphy, P. B. Mullan, E. Rozengurt, and A. J. Lax. 1994. Mutation of a putative ADP-ribosylation motif in the Pasteurella multocida toxin does not affect mitogenic activity. FEBS Lett. 342:81-84.
53. Wong, G. L., and M. C. Ng. 1992. Maturation associated changes in the cellular composition of mouse calvariae and in the biochemical characteristics of calvarial cells separated into subclasses on percoll density gradients. J. Bone Miner. Res 7:701-708.
54. Yoshikawa, T., and T. Hanada. 1981. Histopathological studies on pigs with atrophic rhinitis showing retarded growth. Jpn J. Vet. Sci. 43:221-231.