Widespread and highly persistent gene transfer to the CNS by retrovirus vector in utero: Implication for gene therapy to Krabbe disease

Journal of Gene Medicine

Volumn 7, Issue 5, 2005, Pages 540-551

  Shen, Jin Song ^a   Meng, Xing Li ^a   Yokoo, Takashi ^a   Sakurai, Ken ^a   Watabe, Kazuhiko ^a,b   Ohashi, Toya ^a   Eto, Yoshikatsu ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Central nervous system; Gene therapy; In utero; Lysosomal storage disease; Retrovirus; Twitcher

Indexed keywords

BETA GALACTOSIDASE; RETROVIRUS VECTOR; VIRUS RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BIOCHEMISTRY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME ASSAY; FEASIBILITY STUDY; GENE TRANSFER; GENETIC CODE; GENETIC TRANSDUCTION; GLOBOID CELL LEUKODYSTROPHY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OLIGODENDROGLIA; POLYMERASE CHAIN REACTION; PRENATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; TISSUE DISTRIBUTION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS TITRATION;

ANIMALS; BETA-GALACTOSIDASE; BRAIN; EMBRYO; FEASIBILITY STUDIES; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; LEUKODYSTROPHY, GLOBOID CELL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NEUROLOGIC MUTANTS; NEURONS; PLASMIDS; RETROVIRIDAE; TRANSDUCTION, GENETIC; TRANSGENES;

MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 19744363291     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jgm.719     Document Type: Article

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