Activation of mitochondrial pathway is crucial for tumor selective induction of apoptosis by LAQ824

Cell Cycle

Volumn 5, Issue 15, 2006, Pages 1662-1668

  Wang, Shaowen ^a   Yan Neale, Yan ^a   Cai, Richard ^a   Alimov, Irina ^a   Cohen, Dalia ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Apoptosis; Histone deacetylase; Histone deacetylase inhibitor; Mitochondrial death pathway; Tumor selectivity

Indexed keywords

4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; APOPTOSIS INDUCING FACTOR; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 9; CYTOCHROME C; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; PROTEIN BAX;

ACETYLATION; APOPTOSIS; ARTICLE; CANCER CELL; CHROMATIN IMMUNOPRECIPITATION; COLON CANCER; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG CARCINOMA; MITOCHONDRION; PROTEIN EXPRESSION; RNA BINDING;

EID: 33747836834     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.15.3099     Document Type: Article

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