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Volumn 27, Issue 10, 2006, Pages 1451-1461

Effect of aging on the microglial response to peripheral nerve injury

Author keywords

3H thymidine; Aging; Facial nerve axotomy; Microglia; Microglial proliferation; Programmed cell death; Senescence; TUNEL

Indexed keywords

DNA; LECTIN; THYMIDINE; TRITIUM;

EID: 33747778349     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2005.07.012     Document Type: Article
Times cited : (72)

References (55)
  • 2
    • 0038016402 scopus 로고    scopus 로고
    • Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recovery
    • Badan I., Buchhold B., Hamm A., Gratz M., Walker L.C., Platt D., et al. Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recovery. J Cereb Blood Flow Metab 23 (2003) 845-854
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 845-854
    • Badan, I.1    Buchhold, B.2    Hamm, A.3    Gratz, M.4    Walker, L.C.5    Platt, D.6
  • 3
    • 0025291884 scopus 로고
    • Perineuronal glial responses after axotomy of central and peripheral axons. A comparison
    • Barron K.D., Marciano F.F., Amundson R., and Mankes R. Perineuronal glial responses after axotomy of central and peripheral axons. A comparison. Brain Res 523 (1990) 219-229
    • (1990) Brain Res , vol.523 , pp. 219-229
    • Barron, K.D.1    Marciano, F.F.2    Amundson, R.3    Mankes, R.4
  • 4
    • 0014369295 scopus 로고
    • Displacement of synaptic terminals from regenerating motoneurons by microglial cells
    • Blinzinger K., and Kreutzberg G. Displacement of synaptic terminals from regenerating motoneurons by microglial cells. Z Zellforsch Mikrosk Anat 85 (1968) 145-157
    • (1968) Z Zellforsch Mikrosk Anat , vol.85 , pp. 145-157
    • Blinzinger, K.1    Kreutzberg, G.2
  • 5
    • 0002293117 scopus 로고
    • Juxtavascular karyokinesis and microglia cell proliferation during retrograde reaction in the mouse facial nucleus
    • Cammermeyer J. Juxtavascular karyokinesis and microglia cell proliferation during retrograde reaction in the mouse facial nucleus. Ergeb Anat Entwicklungsgesch 38 (1965) 1-22
    • (1965) Ergeb Anat Entwicklungsgesch , vol.38 , pp. 1-22
    • Cammermeyer, J.1
  • 6
    • 0036882109 scopus 로고    scopus 로고
    • TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia
    • Chen S., Luo D., Streit W.J., and Harrison J.K. TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia. J Neuroimmunol 133 (2002) 46-55
    • (2002) J Neuroimmunol , vol.133 , pp. 46-55
    • Chen, S.1    Luo, D.2    Streit, W.J.3    Harrison, J.K.4
  • 7
    • 0029809030 scopus 로고    scopus 로고
    • Functional outcomes of older adults with traumatic brain injury: a prospective, multicenter analysis
    • Cifu D.X., Kreutzer J.S., Marwitz J.H., Rosenthal M., Englander J., and High W. Functional outcomes of older adults with traumatic brain injury: a prospective, multicenter analysis. Arch Phys Med Rehabil 77 (1996) 883-888
    • (1996) Arch Phys Med Rehabil , vol.77 , pp. 883-888
    • Cifu, D.X.1    Kreutzer, J.S.2    Marwitz, J.H.3    Rosenthal, M.4    Englander, J.5    High, W.6
  • 9
    • 0003176673 scopus 로고    scopus 로고
    • Microglial cell activation in aging and Alzheimer disease: partial linkage with neurofibrillary tangle burden in the hippocampus
    • DiPatre P.L., and Gelman B.B. Microglial cell activation in aging and Alzheimer disease: partial linkage with neurofibrillary tangle burden in the hippocampus. J Neuropathol Exp Neurol 56 (1997) 143-149
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 143-149
    • DiPatre, P.L.1    Gelman, B.B.2
  • 10
    • 0029068714 scopus 로고
    • Microglial turnover in the injured CNS: activated microglia undergo delayed DNA fragmentation following peripheral nerve injury
    • Gehrmann J., and Banati R.B. Microglial turnover in the injured CNS: activated microglia undergo delayed DNA fragmentation following peripheral nerve injury. J Neuropathol Exp Neurol 54 (1995) 680-688
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 680-688
    • Gehrmann, J.1    Banati, R.B.2
  • 11
    • 7644225298 scopus 로고    scopus 로고
    • Intracerebral hemorrhage: effects of aging on brain edema and neurological deficits
    • Gong Y., Hua Y., Keep R.F., Hoff J.T., and Xi G. Intracerebral hemorrhage: effects of aging on brain edema and neurological deficits. Stroke 35 (2004) 2571-2575
    • (2004) Stroke , vol.35 , pp. 2571-2575
    • Gong, Y.1    Hua, Y.2    Keep, R.F.3    Hoff, J.T.4    Xi, G.5
  • 12
    • 0023881117 scopus 로고
    • Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy
    • Graeber M.B., Tetzlaff W., Streit W.J., and Kreutzberg G.W. Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy. Neurosci Lett 85 (1988) 317-321
    • (1988) Neurosci Lett , vol.85 , pp. 317-321
    • Graeber, M.B.1    Tetzlaff, W.2    Streit, W.J.3    Kreutzberg, G.W.4
  • 14
    • 0037404612 scopus 로고    scopus 로고
    • Facial nerve axotomy in aged and young adult rats: analysis of the glial response
    • Hurley S.D., and Coleman P.D. Facial nerve axotomy in aged and young adult rats: analysis of the glial response. Neurobiol Aging 24 (2003) 511-518
    • (2003) Neurobiol Aging , vol.24 , pp. 511-518
    • Hurley, S.D.1    Coleman, P.D.2
  • 16
    • 0023882630 scopus 로고
    • Brain macrophages: questions of origin and interrelationship
    • Jordan F.L., and Thomas W.E. Brain macrophages: questions of origin and interrelationship. Brain Res 472 (1988) 165-178
    • (1988) Brain Res , vol.472 , pp. 165-178
    • Jordan, F.L.1    Thomas, W.E.2
  • 17
    • 0030448928 scopus 로고    scopus 로고
    • Long-term functional status and mortality of elderly patients with severe closed head injuries
    • Kilaru S., Garb J., Emhoff T., Fiallo V., Simon B., Swiencicki T., et al. Long-term functional status and mortality of elderly patients with severe closed head injuries. J Trauma 41 (1996) 957-963
    • (1996) J Trauma , vol.41 , pp. 957-963
    • Kilaru, S.1    Garb, J.2    Emhoff, T.3    Fiallo, V.4    Simon, B.5    Swiencicki, T.6
  • 18
    • 1542268302 scopus 로고    scopus 로고
    • Neuronal susceptibility to damage: comparison of the retinas of young, old and old/caloric restricted rats before and after transient ischemia
    • Kim K.Y., Ju W.K., and Neufeld A.H. Neuronal susceptibility to damage: comparison of the retinas of young, old and old/caloric restricted rats before and after transient ischemia. Neurobiol Aging 25 (2004) 491-500
    • (2004) Neurobiol Aging , vol.25 , pp. 491-500
    • Kim, K.Y.1    Ju, W.K.2    Neufeld, A.H.3
  • 19
    • 0000718570 scopus 로고
    • Autoradiographische Untersuchung uber die Beteiligung von Gliazellen an der axonalen Reaktion im Facialiskern der Ratte
    • Kreutzberg G. Autoradiographische Untersuchung uber die Beteiligung von Gliazellen an der axonalen Reaktion im Facialiskern der Ratte. Acta Neuropathol (Berl) 7 (1966) 149-161
    • (1966) Acta Neuropathol (Berl) , vol.7 , pp. 149-161
    • Kreutzberg, G.1
  • 20
    • 0014394740 scopus 로고
    • Autoradiographic studies on perineuronal microgliocytes
    • Kreutzberg G.W. Autoradiographic studies on perineuronal microgliocytes. Acta Neuropathol (Berl) Suppl 4 (1968) 141-145
    • (1968) Acta Neuropathol (Berl) , Issue.SUPPL. 4 , pp. 141-145
    • Kreutzberg, G.W.1
  • 21
    • 0035957802 scopus 로고    scopus 로고
    • Microglial activation, emergence of ED1-expressing cells and clusterin upregulation in the aging rat CNS, with special reference to the spinal cord
    • Kullberg S., Aldskogius H., and Ulfhake B. Microglial activation, emergence of ED1-expressing cells and clusterin upregulation in the aging rat CNS, with special reference to the spinal cord. Brain Res 899 (2001) 169-186
    • (2001) Brain Res , vol.899 , pp. 169-186
    • Kullberg, S.1    Aldskogius, H.2    Ulfhake, B.3
  • 22
    • 0035479019 scopus 로고    scopus 로고
    • Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury
    • Kyrkanides S., O'Banion M.K., Whiteley P.E., Daeschner J.C., and Olschowka J.A. Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury. J Neuroimmunol 119 (2001) 269-277
    • (2001) J Neuroimmunol , vol.119 , pp. 269-277
    • Kyrkanides, S.1    O'Banion, M.K.2    Whiteley, P.E.3    Daeschner, J.C.4    Olschowka, J.A.5
  • 23
    • 0030995379 scopus 로고    scopus 로고
    • Increased transcription of the astrocyte gene GFAP during middle-age is attenuated by food restriction: implications for the role of oxidative stress
    • Morgan T.E., Rozovsky I., Goldsmith S.K., Stone D.J., Yoshida T., and Finch C.E. Increased transcription of the astrocyte gene GFAP during middle-age is attenuated by food restriction: implications for the role of oxidative stress. Free Radic Biol Med 23 (1997) 524-528
    • (1997) Free Radic Biol Med , vol.23 , pp. 524-528
    • Morgan, T.E.1    Rozovsky, I.2    Goldsmith, S.K.3    Stone, D.J.4    Yoshida, T.5    Finch, C.E.6
  • 24
    • 0032910605 scopus 로고    scopus 로고
    • The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction
    • Morgan T.E., Xie Z., Goldsmith S., Yoshida T., Lanzrein A.S., Stone D., et al. The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction. Neuroscience 89 (1999) 687-699
    • (1999) Neuroscience , vol.89 , pp. 687-699
    • Morgan, T.E.1    Xie, Z.2    Goldsmith, S.3    Yoshida, T.4    Lanzrein, A.S.5    Stone, D.6
  • 25
    • 2942755854 scopus 로고    scopus 로고
    • The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial
    • Mosenthal A.C., Livingston D.H., Lavery R.F., Knudson M.M., Lee S., Morabito D., et al. The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial. J Trauma 56 (2004) 1042-1048
    • (2004) J Trauma , vol.56 , pp. 1042-1048
    • Mosenthal, A.C.1    Livingston, D.H.2    Lavery, R.F.3    Knudson, M.M.4    Lee, S.5    Morabito, D.6
  • 26
    • 0028309624 scopus 로고
    • Effects of ageing on microglia in the normal rat brain: immunohistochemical observations
    • Ogura K., Ogawa M., and Yoshida M. Effects of ageing on microglia in the normal rat brain: immunohistochemical observations. Neuroreport 5 (1994) 1224-1226
    • (1994) Neuroreport , vol.5 , pp. 1224-1226
    • Ogura, K.1    Ogawa, M.2    Yoshida, M.3
  • 27
    • 20244363484 scopus 로고    scopus 로고
    • Quantitative and ultrastructural changes in glia and pericytes in the parietal cortex of the aging rat
    • Peinado M.A., Quesada A., Pedrosa J.A., Torres M.I., Martinez M., Esteban F.J., et al. Quantitative and ultrastructural changes in glia and pericytes in the parietal cortex of the aging rat. Microsc Res Technol 43 (1998) 34-42
    • (1998) Microsc Res Technol , vol.43 , pp. 34-42
    • Peinado, M.A.1    Quesada, A.2    Pedrosa, J.A.3    Torres, M.I.4    Martinez, M.5    Esteban, F.J.6
  • 28
    • 0027352040 scopus 로고
    • Altered antigen expression of microglia in the aged rodent CNS
    • Perry V.H., Matyszak M.K., and Fearn S. Altered antigen expression of microglia in the aged rodent CNS. Glia 7 (1993) 60-67
    • (1993) Glia , vol.7 , pp. 60-67
    • Perry, V.H.1    Matyszak, M.K.2    Fearn, S.3
  • 29
    • 0036133121 scopus 로고    scopus 로고
    • The effects of age on the cells in layer 1 of primate cerebral cortex
    • Peters A., and Sethares C. The effects of age on the cells in layer 1 of primate cerebral cortex. Cereb Cortex 12 (2002) 27-36
    • (2002) Cereb Cortex , vol.12 , pp. 27-36
    • Peters, A.1    Sethares, C.2
  • 30
    • 0011440642 scopus 로고    scopus 로고
    • Microglial response in the axotomized facial motor nucleus
    • Streit W.J. (Ed), Springer-Verlag, New York
    • Raivich G. Microglial response in the axotomized facial motor nucleus. In: Streit W.J. (Ed). Microglia in the regenerating and degenerating central nervous system (2002), Springer-Verlag, New York 166-187
    • (2002) Microglia in the regenerating and degenerating central nervous system , pp. 166-187
    • Raivich, G.1
  • 31
    • 0027405762 scopus 로고
    • Quantitative immunohistochemistry in the rat facial nucleus with [125I]-iodinated secondary antibodies and in situ autoradiography: non-linear binding characteristics of primary monoclonal and polyclonal antibodies
    • Raivich G., Gehrmann J., Graeber M.B., and Kreutzberg G.W. Quantitative immunohistochemistry in the rat facial nucleus with [125I]-iodinated secondary antibodies and in situ autoradiography: non-linear binding characteristics of primary monoclonal and polyclonal antibodies. J Histochem Cytochem 41 (1993) 579-592
    • (1993) J Histochem Cytochem , vol.41 , pp. 579-592
    • Raivich, G.1    Gehrmann, J.2    Graeber, M.B.3    Kreutzberg, G.W.4
  • 32
    • 0036849021 scopus 로고    scopus 로고
    • Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide
    • Rogers J., Strohmeyer R., Kovelowski C.J., and Li R. Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia 40 (2002) 260-269
    • (2002) Glia , vol.40 , pp. 260-269
    • Rogers, J.1    Strohmeyer, R.2    Kovelowski, C.J.3    Li, R.4
  • 33
    • 0031960552 scopus 로고    scopus 로고
    • Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation
    • Rozovsky I., Finch C.E., and Morgan T.E. Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation. Neurobiol Aging 19 (1998) 97-103
    • (1998) Neurobiol Aging , vol.19 , pp. 97-103
    • Rozovsky, I.1    Finch, C.E.2    Morgan, T.E.3
  • 34
    • 0031960498 scopus 로고    scopus 로고
    • Microglial expression of MHC class II increases in normal aging of nonhuman primates
    • Sheffield L.G., and Berman N.E. Microglial expression of MHC class II increases in normal aging of nonhuman primates. Neurobiol Aging 19 (1998) 47-55
    • (1998) Neurobiol Aging , vol.19 , pp. 47-55
    • Sheffield, L.G.1    Berman, N.E.2
  • 35
    • 0031909973 scopus 로고    scopus 로고
    • Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain
    • Sheng J.G., Mrak R.E., and Griffin W.S. Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain. Acta Neuropathol (Berl) 95 (1998) 229-234
    • (1998) Acta Neuropathol (Berl) , vol.95 , pp. 229-234
    • Sheng, J.G.1    Mrak, R.E.2    Griffin, W.S.3
  • 36
    • 0032806355 scopus 로고    scopus 로고
    • Increased microglial activation and protein nitration in white matter of the aging monkey
    • Sloane J.A., Hollander W., Moss M.B., Rosene D.L., and Abraham C.R. Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiol Aging 20 (1999) 395-405
    • (1999) Neurobiol Aging , vol.20 , pp. 395-405
    • Sloane, J.A.1    Hollander, W.2    Moss, M.B.3    Rosene, D.L.4    Abraham, C.R.5
  • 37
    • 0036847816 scopus 로고    scopus 로고
    • Microglia as neuroprotective, immunocompetent cells of the CNS
    • Streit W.J. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40 (2002) 133-139
    • (2002) Glia , vol.40 , pp. 133-139
    • Streit, W.J.1
  • 38
    • 3042845492 scopus 로고    scopus 로고
    • Microglia Alzheimer's disease pathogenesis
    • Streit W.J. Microglia Alzheimer's disease pathogenesis. J Neurosci Res 77 (2004) 1-8
    • (2004) J Neurosci Res , vol.77 , pp. 1-8
    • Streit, W.J.1
  • 39
    • 17844404517 scopus 로고    scopus 로고
    • Microglia and neuroprotection: implications for Alzheimer's disease
    • Streit W.J. Microglia and neuroprotection: implications for Alzheimer's disease. Brain Res Brain Res Rev 48 (2005) 234-239
    • (2005) Brain Res Brain Res Rev , vol.48 , pp. 234-239
    • Streit, W.J.1
  • 40
    • 0024199439 scopus 로고
    • Functional plasticity of microglia: a review
    • Streit W.J., Graeber M.B., and Kreutzberg G.W. Functional plasticity of microglia: a review. Glia 1 (1988) 301-307
    • (1988) Glia , vol.1 , pp. 301-307
    • Streit, W.J.1    Graeber, M.B.2    Kreutzberg, G.W.3
  • 41
    • 0034234414 scopus 로고    scopus 로고
    • Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration
    • Streit W.J., Hurley S.D., McGraw T.S., and Semple-Rowland S.L. Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration. J Neurosci Res 61 (2000) 10-20
    • (2000) J Neurosci Res , vol.61 , pp. 10-20
    • Streit, W.J.1    Hurley, S.D.2    McGraw, T.S.3    Semple-Rowland, S.L.4
  • 42
    • 0023213595 scopus 로고
    • Lectin binding by resting and reactive microglia
    • Streit W.J., and Kreutzberg G.W. Lectin binding by resting and reactive microglia. J Neurocytol 16 (1987) 249-260
    • (1987) J Neurocytol , vol.16 , pp. 249-260
    • Streit, W.J.1    Kreutzberg, G.W.2
  • 43
    • 7744224673 scopus 로고    scopus 로고
    • Microglia and neuroinflammation: a pathological perspective
    • Streit W.J., Mrak R.E., and Griffin W.S. Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation 1 (2004) 14
    • (2004) J Neuroinflammation , vol.1 , pp. 14
    • Streit, W.J.1    Mrak, R.E.2    Griffin, W.S.3
  • 44
    • 1042291300 scopus 로고    scopus 로고
    • Dystrophic microglia in the aging human brain
    • Streit W.J., Sammons N.W., Kuhns A.J., and Sparks D.L. Dystrophic microglia in the aging human brain. Glia 45 (2004) 208-212
    • (2004) Glia , vol.45 , pp. 208-212
    • Streit, W.J.1    Sammons, N.W.2    Kuhns, A.J.3    Sparks, D.L.4
  • 45
    • 0030967157 scopus 로고    scopus 로고
    • Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits
    • Streit W.J., and Sparks D.L. Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits. J Mol Med 75 (1997) 130-138
    • (1997) J Mol Med , vol.75 , pp. 130-138
    • Streit, W.J.1    Sparks, D.L.2
  • 46
  • 47
    • 0035087707 scopus 로고    scopus 로고
    • Molecular and cellular mediators of Alzheimer's disease inflammation
    • Strohmeyer R., and Rogers J. Molecular and cellular mediators of Alzheimer's disease inflammation. J Alzheimers Dis 3 (2001) 131-157
    • (2001) J Alzheimers Dis , vol.3 , pp. 131-157
    • Strohmeyer, R.1    Rogers, J.2
  • 48
    • 0034705679 scopus 로고    scopus 로고
    • Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury
    • Stuesse S.L., Cruce W.L., Lovell J.A., McBurney D.L., and Crisp T. Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury. Neurosci Lett 287 (2000) 121-124
    • (2000) Neurosci Lett , vol.287 , pp. 121-124
    • Stuesse, S.L.1    Cruce, W.L.2    Lovell, J.A.3    McBurney, D.L.4    Crisp, T.5
  • 49
    • 0036686065 scopus 로고    scopus 로고
    • Traumatic brain injury in the elderly: increased mortality and worse functional outcome at discharge despite lower injury severity
    • [discussion 23-4]
    • Susman M., DiRusso S.M., Sullivan T., Risucci D., Nealon P., Cuff S., et al. Traumatic brain injury in the elderly: increased mortality and worse functional outcome at discharge despite lower injury severity. J Trauma 53 (2002) 219-223 [discussion 23-4]
    • (2002) J Trauma , vol.53 , pp. 219-223
    • Susman, M.1    DiRusso, S.M.2    Sullivan, T.3    Risucci, D.4    Nealon, P.5    Cuff, S.6
  • 50
    • 0028609424 scopus 로고
    • A bromodeoxyuridine labelling study of proliferating cells in the brainstem following hypoglossal nerve transection
    • Svensson M., Mattsson P., and Aldskogius H. A bromodeoxyuridine labelling study of proliferating cells in the brainstem following hypoglossal nerve transection. J Anat 185 Pt 3 (1994) 537-542
    • (1994) J Anat , vol.185 , Issue.PART 3 , pp. 537-542
    • Svensson, M.1    Mattsson, P.2    Aldskogius, H.3
  • 51
    • 0026708978 scopus 로고
    • Brain macrophages: evaluation of microglia and their functions
    • Thomas W.E. Brain macrophages: evaluation of microglia and their functions. Brain Res Brain Res Rev 17 (1992) 61-74
    • (1992) Brain Res Brain Res Rev , vol.17 , pp. 61-74
    • Thomas, W.E.1
  • 52
    • 0030007211 scopus 로고    scopus 로고
    • Perineuronal microglial reactivity following proximal and distal axotomy of rat rubrospinal neurons
    • Tseng G.F., Wang Y.J., and Lai Q.C. Perineuronal microglial reactivity following proximal and distal axotomy of rat rubrospinal neurons. Brain Res 715 (1996) 32-43
    • (1996) Brain Res , vol.715 , pp. 32-43
    • Tseng, G.F.1    Wang, Y.J.2    Lai, Q.C.3
  • 53
    • 0025003371 scopus 로고
    • Effects of advancing age on the central response of rat facial neurons to axotomy: light microscope morphometry
    • Vaughan D.W. Effects of advancing age on the central response of rat facial neurons to axotomy: light microscope morphometry. Anat Rec 228 (1990) 211-219
    • (1990) Anat Rec , vol.228 , pp. 211-219
    • Vaughan, D.W.1
  • 54
    • 0026788152 scopus 로고
    • Effects of advancing age on peripheral nerve regeneration
    • Vaughan D.W. Effects of advancing age on peripheral nerve regeneration. J Comp Neurol 323 (1992) 219-237
    • (1992) J Comp Neurol , vol.323 , pp. 219-237
    • Vaughan, D.W.1
  • 55
    • 0016261856 scopus 로고
    • Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study
    • Vaughan D.W., and Peters A. Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study. J Neurocytol 3 (1974) 405-429
    • (1974) J Neurocytol , vol.3 , pp. 405-429
    • Vaughan, D.W.1    Peters, A.2


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