Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity

Journal of Biological Chemistry

Volumn 281, Issue 34, 2006, Pages 24489-24495

  Ishiyama, Noboru ^a   Creuzenet, Carole ^b   Miller, Wayne L ^c   Demendi, Melinda ^b   Anderson, Erin M ^c   Harauz, George ^c   Lam, Joseph S ^c   Berghuis, Albert M ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CARBOHYDRATES; CRYSTAL STRUCTURE; DEHYDROGENATION; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

DEHYDROGENASE; HUMAN PATHOGENS; PATHOGENICITY; PROTEIN GLYCOSYLATION;

ENZYME KINETICS;

4,6 DEHYDRATASE; HYDROLYASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BIOSYNTHESIS; CRYSTAL STRUCTURE; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME SUBSTRATE; FLAA1 GENE; HELICOBACTER PYLORI; NUCLEAR MAGNETIC RESONANCE; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN QUATERNARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

BACTERIAL PROTEINS; GLYCOSYLATION; HELICOBACTER PYLORI; HYDRO-LYASES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES; PROMOTER REGIONS (GENETICS); STRUCTURE-ACTIVITY RELATIONSHIP; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE;

HELICOBACTER PYLORI;

EID: 33747658415     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602393200     Document Type: Article

References (50)

1. Marshall, B. J., and Warren, J. R. (1984) Lancet 1, 1311-1315
2. Graham, D. Y., Klein, P. D., Opekun, A. R., and Boutton, T. W. (1988) J. Infect. Dis. 157, 777-780
3. Forman, D., Newell, D. G., Fullerton, F., Yarnell, J. W., Stacey, A. R., Wald, N., and Sitas, F. (1991) Br. Med. J. 302, 1302-1305
4. Parsonnet, J., Friedman, G. D., Vandersteen, D. P., Chang, Y., Vogelman, J. H., Orentreich, N., and Sibley, R. K. (1991) N. Engl. J. Med. 325, 1127-1131
5. Dunn, B. E., Campbell, G. P., Perez-Perez, G. I., and Blaser, M. J. (1990) J. Biol. Chem. 265, 9464-9469
6. Monteiro, M. A., Chan, K. H., Rasko, D. A., Taylor, D. E., Zheng, P. Y., Appelmelk, B. J., Wirth, H. P., Yang, M., Blaser, M. J., Hynes, S. O., Moran, A. P., and Perry, M. B. (1998) J. Biol. Chem. 273, 11533-11543
7. Josenhans, C., Labigne, A., and Suerbaum, S. (1995) J. Bacteriol. 177, 3010-3020
8. Appelmelk, B. J., Monteiro, M. A., Martin, S. L., Moran, A. P., and Vandenbroucke-Grauls, C. M. (2000) Trends Microbiol. 8, 565-570
9. Merkx-Jacques, A., Obhi, R. K., Bethune, G., and Creuzenet, C. (2004) J. Bacteriol. 186, 2253-2265
10. Schirm, M., Soo, E. C., Aubry, A. J., Austin, J., Thibault, P., and Logan, S. M. (2003) Mol. Microbiol. 48, 1579-1592
11. Creuzenet, C., Schur, M. J., Li, J., Wakarchuk, W. W., and Lam, J. S. (2000) J. Biol. Chem. 275, 34873-34880
12. Schoenhofen, I. C., McNally, D. J., Vinogradov, E., Whitfield, D., Young, M., Dick, S., Wakarchuk, W. W., Brisson, J. R., and Logan, S. M. (2005) J. Biol. Chem. 281, 723-732
13. Thoden, J. B., Frey, P. A., and Holden, H. M. (1996) Biochemistry 35, 5137-5144
14. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
15. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D. Biol. Crystallogr. 54, 905-921
16. Ishiyama, N., Creuzenet, C., Lam, J. S., and Berghuis, A. M. (2004) J. Biol. Chem. 279, 22635-22642
17. Kleywegt, G. J., and Jones, T. A. (1994) in From First Map to Final Model (Bailey, S., Hubbard, R., and Waller, D., eds) pp. 59-66, SERC Daresbury Laboratory, Warrington, UK
18. van Heel, M., Harauz, G., Orlova, E. V., Schmidt, R., and Schatz, M. (1996) J. Struct. Biol. 116, 17-24
19. van Heel, M., Gowen, B., Matadeen, R., Orlova, E. V., Finn, R., Pape, T., Cohen, D., Stark, H., Schmidt, R., Schatz, M., and Patwardhan, A. (2000) Q. Rev. Biophys. 33, 307-369
20. Creuzenet, C., Urbanic, R. V., and Lam, J. S. (2002) J. Biol. Chem. 277, 26769-26778
21. Vriend, G. (1990) J. Mol. Graphics 8, 52-56
22. Nielsen, J. E., and McCammon, J. A. (2003) Protein Sci. 12, 1894-1901
23. Nielsen, J. E., and McCammon, J. A. (2003) Protein Sci. 12, 313-326
24. Nicholls, A., and Honig, B. (1991) J. Comput. Chem. 12, 435-445
25. Halgren, T. A. (1996) J. Comput. Chem. 17, 490-519
26. Schuttelkopf, A. W., and van Aalten, D. M. (2004) Acta Crystallogr. Sect. D. Biol. Crystallogr. 60, 1355-1363
27. Bashford, D., and Karplus, M. (1990) Biochemistry 29, 10219-10225
28. Thoden, J. B., Wohlers, T. M., Fridovich-Keil, J. L., and Holden, H. M. (2001) J. Biol. Chem. 276, 15131-15136
29. Allard, S. T., Beis, K., Giraud, M. F., Hegeman, A. D., Gross, J. W., Wilmouth, R. C., Whitfield, C., Graninger, M., Messner, P., Allen, A. G., Maskell, D. J., and Naismith, J. H. (2002) Structure (Camb.) 10, 81-92
30. Thoden, J. B., Wohlers, T. M., Fridovich-Keil, J. L., and Holden, H. M. (2000) Biochemistry 39, 5691-5701
31. Kneidinger, B., O'Riordan, K., Li, J., Brisson, J. R., Lee, J. C., and Lam, J. S. (2003) J. Biol. Chem. 278, 3615-3627
32. Allard, S. T., Giraud, M. F., Whitfield, C., Graninger, M., Messner, P., and Naismith, J. H. (2001) J. Mol. Biol. 307, 283-295
33. Allard, S. T., Cleland, W. W., and Holden, H. M. (2004) J. Biol. Chem. 279, 2211-2220
34. Webb, N. A., Mulichak, A. M., Lam, J. S., Rocchetta, H. L., and Garavito, R. M. (2004) Protein Sci. 13, 529-539
35. Mulichak, A. M., Bonin, C. P., Reiter, W. D., and Garavito, R. M. (2002) Biochemistry 41, 15578-15589
36. Vogan, E. M., Bellamacina, C., He, X., Liu, H. W., Ringe, D., and Petsko, G. A. (2004) Biochemistry 43, 3057-3067
37. Koropatkin, N. M., and Holden, H. M. (2005) Acta Crystallogr. Sect. D. Biol. Crystallogr. 61, 365-373
38. Hegeman, A. D., Gross, J. W., and Frey, P. A. (2002) Biochemistry 41, 2797-2804
39. Gross, J. W., Hegeman, A. D., Gerratana, B., and Frey, P. A. (2001) Biochemistry 40, 12497-12504
40. Gerratana, B., Cleland, W. W., and Frey, P. A. (2001) Biochemistry 40, 9187-9195
41. Strynadka, N. C., Adachi, H., Jensen, S. E., Johns, K., Sielecki, A., Betzel, C., Sutoh, K., and James, M. N. (1992) Nature 359, 700-705
42. Creuzenet, C. (2004) FEBS Lett. 559, 136-140
43. Thibault, P., Logan, S. M., Kelly, J. F., Brisson, J. R., Ewing, C. P., Trust, T. J., and Guerry, P. (2001) J. Biol. Chem. 276, 34862-34870
44. Gunawan, J., Simard, D., Gilbert, M., Lovering, A. L., Wakarchuk, W. W., Tanner, M. E., and Strynadka, N. C. (2005) J. Biol. Chem. 280, 3555-3563
45. Murkin, A. S., Chou, W. K., Wakarchuk, W. W., and Tanner, M. E. (2004) Biochemistry 43, 14290-14298
46. Alm, R. A., Ling, L. S., Moir, D. T., King, B. L., Brown, E. D., Doig, P. C., Smith, D. R., Noonan, B., Guild, B. C., deJonge, B. L., Carmel, G., Tummino, P. J., Caruso, A., Uria-Nickelsen, M., Mills, D. M., Ives, C., Gibson, R., Merberg, D., Mills, S. D., Jiang, Q., Taylor, D. E., Vovis, G. F., and Trust, T. J. (1999) Nature 397, 176-180
47. Tomb, J. F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S., Dougherty, B. A., Nelson, K., Quackenbush, J., Zhou, L., Kirkness, E. F., Peterson, S., Loftus, B., Richardson, D., Dodson, R., Khalak, H. G., Glodek, A., McKenney, K., Fitzegerald, L. M., Lee, N., Adams, M. D., Hickey, E. K., Berg, D. E., Gocayne, J. D., Utterback, T. R., Peterson, J. D., Kelly, J. M., Cotton, M. D., Weidman, J. M., Fujii, C., Bowman, C., Watthey, L., Wallin, E., Hayes, W. S., Borodovsky, M., Karp, P. D., Smith, H. O., Fraser, C. M., and Venter, J. C. (1997) Nature 388, 539-547
48. Goon, S., Kelly, J. F., Logan, S. M., Ewing, C. P., and Guerry, P. (2003) Mol. Microbiol. 50, 659-671
49. Obhi, R. K., and Creuzenet, C. (2005) J. Biol. Chem. 280, 20902-20908
50. Chou, W. K., Dick, S., Wakarchuk, W. W., and Tanner, M. E. (2005) J. Biol. Chem. 280, 35922-35928