Addition of an extra substrate binding site and partial destabilization of stem structures in HDV ribozyme give rise to high sequence-specificity for its target RNA

Nucleosides, Nucleotides and Nucleic Acids

Volumn 25, Issue 4-6, 2006, Pages 489-501

  Hori, Tamaki ^a   Guo, Fei ^a   Uesugi, Seiichi ^a  

^a YOKOHAMA NATIONAL UNIVERSITY   (Japan)

Author keywords

HDV ribozyme; RNA cleavage; Substrate recognition

Indexed keywords

MESSENGER RNA; RIBOZYME; VIRUS ENZYME;

ARTICLE; BINDING AFFINITY; BINDING SITE; ENZYME ACTIVE SITE; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HEPATITIS DELTA VIRUS; IN VIVO STUDY; NONHUMAN; PROTEIN TARGETING;

BASE SEQUENCE; BINDING SITES; HEPATITIS DELTA VIRUS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA; RNA, CATALYTIC; SUBSTRATE SPECIFICITY;

EID: 33747612153     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770600684183     Document Type: Article

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