Cleavage reaction of HDV ribozymes in the presence of Mg2+ is accompanied by a conformational change

Genes to Cells

Volumn 7, Issue 6, 2002, Pages 567-579

  Tanaka, Yoichiro ^a   Tagaya, Mitsuhiro ^a   Hori, Tamaki ^a   Sakamoto, Taiichi ^a   Kurihara, Yasuyuki ^a   Katahira, Masato ^a   Uesugi, Seiichi ^a  

^a YOKOHAMA NATIONAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE; GUANINE; MAGNESIUM CHLORIDE; MAGNESIUM ION; RIBOZYME; URIDINE; VIRUS ENZYME; MAGNESIUM;

ARTICLE; BASE PAIRING; BINDING SITE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME STABILITY; ENZYME SUBSTRATE; HEPATITIS DELTA VIRUS; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RNA DEGRADATION; SIGNAL TRANSDUCTION; SPECTROSCOPY; TERMINAL SEQUENCE; TITRIMETRY; CHEMISTRY; CONFORMATION; GENETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

HEPATITIS DELTA VIRUS; MAGNESIUM; MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACID CONFORMATION; RNA, CATALYTIC; SUPPORT, NON-U.S. GOV'T;

HEPATITIS DELTA VIRUS;

EID: 0035998267     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2002.00541.x     Document Type: Article

References (27)

1. The kinetics and magnesium requirements for the folding of antigenomic δ ribozymes
2. Cis- and trans-acting ribozymes from a human pathogen, hepatitis delta virus
3. Secondary structure of the self-cleavage RNA of hepatitis delta virus: Applications to catalytic RNA design
4. Use of inorganic pyrophosphatase to improve the yield of in vitro transcription reactions catalyzed by T7 RNA polymerase
5. Cloning and expression of the gene for bacteriophage T7
6. Crystal structure of a hepatitis delta virus ribozyme
7. Synthesis and hybridization studies on two complementary nona (2′-O-methyl) ribonucleotides
8. Characterization of self-cleaving RNA sequences on the genome and antigenome of human hepatitis delta virus
9. The molecular biology of hepatitis delta virus
10. Recommendations for the presentation of NMR structures of proteins and nucleic acids
11. T7 RNA polymerase does not interact with the 5′-phosphate of the initiating nucleotide
12. Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates
13. General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme
14. Mechanistic characterization of the HDV genomic ribozyme: Assessing the catalytic and structural contributions of divalent metal ions within a multichannel reaction mechanism
15. Requirement for canonical base pairing in the short pseudoknot structure of genomic hepatitis delta virus ribozyme
16. Synthesis and NMR study of ribooligonucleotides forming a hammerhead-type RNA enzyme system
17. The self-cleaving domain from the genomic RNA of hepatitis delta virus: Sequence requirements and the effects of denaturant
18. A pseudoknot-like structure required for efficient self-cleavage of hepatitis delta virus RNA
19. Exchangeable proton NMR without base-line distortion, using new strong-pulse sequences
20. Properties of hepatitis delta virus ribozyme, which consists of three RNA oligomer strands
21. Antigenomic RNA of human hepatitis delta virus can undergo self-cleavage
22. Kinetic scheme for intermolecular RNA cleavage by a ribozyme derived from hepatitis delta virus RNA
23. Energetic contribution of non-essential 5′ sequence to catalysis in a hepatitis delta virus ribozyme
24. 2+ ion binding site close to the catalytic core in solution
25. A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes
26. A pH-sensitive RNA tertiary interaction affects self-cleavage activity of the HDV ribozymes in the absence of added divalent metal ion
27. Sequence and structure of the catalytic RNA of hepatitis delta virus genomic RNA