Functional characterization of the SOFA delta ribozyme

RNA

Volumn 11, Issue 12, 2005, Pages 1858-1868

  Bergeron Jr , Lucien ^a   Reymond, Cédric ^a   Perreault, Jean Pierre ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Hepatitis B and C viruses; Rational design; Riboswitch; Ribozyme; Substrate specificity

Indexed keywords

NUCLEOTIDE; RIBONUCLEASE; RIBOZYME;

ANIMAL CELL; ARTICLE; BIOSENSOR; CATALYSIS; GENE ACTIVATION; GENE FUNCTION; GENE INACTIVATION; GENE SEQUENCE; GENE STRUCTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN;

BASE SEQUENCE; HEPATITIS DELTA VIRUS; HEPATITIS VIRUSES; HUMANS; HYDROLYSIS; KINETICS; MODELS, GENETIC; MUTATION; NUCLEIC ACID CONFORMATION; RIBONUCLEASE H, CALF THYMUS; RNA; RNA, CATALYTIC; RNA, VIRAL; SUBSTRATE SPECIFICITY; VARIATION (GENETICS);

ANIMALIA;

EID: 28344440287     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.2112705     Document Type: Article

References (20)

1. Al-Anouti, F. and Ananvoranich, S. 2002. Comparative analysis of antisense RNA, double stranded RNA, and delta ribozymemediated gene regulation in toxoplasma gondii. Antisense Nucleic Acid Drug Dev. 12: 275-281.
2. Bagheri, S. and Kashani-Sabet, M. 2004. Ribozymes in the age of molecular therapeutics. Curr. Mol. Med. 4: 489-506.
3. Bergeron, L.J. and Perreault, J.P. 2002. Development and comparison of procedures for the selection of delta ribozyme cleavage sites within the hepatitis B virus. Nucleic Acids Res. 30: 4682-4691.
4. -. 2005. Target-dependent on/off switch increases ribozyme fidelity. Nucleic Acids Res. 33: 1240-1248.
5. Bergeron, L.J., Ouellet, J., and Perreault, J.-P. 2003. Ribozyme-based gene-inactivation systems require a fine comprehension of their substrate specificities: The case of delta ribozyme. Curr. Med. Chem. 10: 2589-2597.
6. Breaker, R.R. 2004. Natural and engineered nucleic acids as tools to explore biology. Nature 432: 838-845.
7. D'Anjou, F., Bergeron, L.J., Larbi, N.B., Fournier, I., Salzet, M., Perreault, J.-P., and Day, R. 2004. Silencing of SPC2 expression using an engineered d ribozyme in the mouse βTC-3 endocrine cell line. J. Biol. Chem. 279: 14232-14239.
8. Deschênes, P., Lafontaine, D.A., Charland, S., and Perreault, J.P. 2000. Nucleotides -1 to -4 of hepatitis δ ribozyme substrate increase the specificity of ribozyme cleavage. Antisense Nucleic Acid Drug Dev. 10: 53-61.
9. Deschênes, P., Ouellet, J., Perreault, J., and Perreault, J.P. 2003. Formation of the P1.1 pseudoknot is critical for both the cleavage activity and substrate specificity of an antigenomic trans-acting hepatitis delta ribozyme. Nucleic Acids Res. 31: 2087-2096.
10. Kato, Y., Kuwabara, T., Warashina, M., Toda, H., and Taira, K. 2001. Relationships between the activities in vitro and in vivo of various kinds of ribozyme and their intracellular localization in mammalian cells. J. Biol. Chem. 276: 15378-15385.
11. Lévesque, D., Choufani, S., and Perreault, J.P. 2002. Delta ribozyme benefits from a good stability in vitro that becomes outstanding in vivo. RNA 8: 464-477.
12. Mercure, S., Lafontaine, D., Ananvoranich, S., and Perreault, J.-P. 1998. Kinetic analysis of δ ribozyme cleavage. Biochemistry 37: 16975-16982.
13. Nassal, M. 1992. The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly. J. Virol. 66: 4107-4116.
14. Nielsen, P.E. 2000. Peptide nucleic acids: On the road to new gene therapeutic drugs. Pharmacol. Toxicol. 86: 3-7.
15. Nishikawa, F., Roy, M., Fauzi, H., and Nishikawa, S. 1999. Detailed analysis of stem I and its 5′ and 3′ neighbor regions in the transacting HDV ribozyme. Nucleic Acids Res. 27: 403-410.
16. Pebernard, S. and Iggo, R.D. 2004. Determinants of interferon-stimulated gene induction by RNAi vectors. Differentiation 72: 103-111.
17. Perrotta, A.T. and Been, M.D. 1991. A pseudoknot-like structure required for efficient self-cleavage of hepatitis delta virus RNA. Nature 350: 434-436.
18. Sheng, J., Al-Anouti, F., and Ananvoranich, S. 2004. Engineered delta ribozymes can simultaneously knock down the expression of the genes encoding uracil phosphoribosyltransferase and hypoxanthine-xanthine-guanine phosphoribosyl-transferase in Toxoplasma gondii. Inter. J. Parasitol. 34: 253-263.
19. Shih, I.H. and Been, M.D. 2002. Catalytic strategies of the hepatitis delta virus ribozymes. Annu. Rev. Biochem. 71: 887-917.
20. Sledz, C.A., Holko, M., de Veer, M.J., Silverman, R.H., and Williams, B.R. 2003. Activation of the interferon system by short-interfering RNAs. Nat. Cell Biol. 5: 834-839.