Inhibition of insulin-like growth factor binding protein 5 proteolysis in articular cartilage and joint fluid results in enhanced concentrations of insulin-like growth factor 1 and is associated with improved osteoarthritis

Arthritis and Rheumatism

Volumn 46, Issue 3, 2002, Pages 694-703

  Clemmons, David R ^a,d   Busby Jr , Walker H ^a   Garmong, Aaron ^a   Schultz, Duane R ^b   Howell, David S ^b   Altman, Roy D ^b   Karr, Robert ^c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c Monsanto/Searle   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN III; BUFFER; COLLAGENASE; COMPLEMENT COMPONENT C1; PB 145; PENTOSAN POLYSULFATE; PROTEINASE; SERINE PROTEINASE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE DEGENERATION; CONTROLLED STUDY; DOG; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; JOINT DESTRUCTION; LIGAMENT INJURY; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SYNOVIAL FLUID;

ANIMALS; ANTITHROMBIN III; CARTILAGE, ARTICULAR; COMPLEMENT C1S; DOGS; ENZYME INHIBITORS; FEMALE; HINDLIMB; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; INSULIN-LIKE GROWTH FACTOR I; OSMOLAR CONCENTRATION; OSTEOARTHRITIS; PENTOSAN SULFURIC POLYESTER; PEPTIDE FRAGMENTS; SYNOVIAL FLUID;

EID: 0036122157     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.10222     Document Type: Article

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