Apoptosis and proliferation in gastric epithelium due to Helicobacter pylori: An immunohistochemical and ultrastructural study

Acta Gastro-Enterologica Belgica

Volumn 69, Issue 2, 2006, Pages 191-196

  Karabay, Gülten ^a   Nacar, A ^a   Can, F ^a   Demirbilek, M ^a   Bacanli, D ^a   Take, G ^a   Yazici, A C ^a  

^a BASKENT UNIVERSITY   (Turkey)

Author keywords

Electron microscopy; Gastric epithelium; Helicobacter pylori; Immunohistochemistry

Indexed keywords

CASPASE 3; EPIDERMAL GROWTH FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM ISOLATION; CELL PROLIFERATION; CELL ULTRASTRUCTURE; CHROMATIN; CONTROLLED STUDY; DISEASE DURATION; ELECTRON MICROSCOPY; ENZYME REACTIVATION; EPITHELIUM CELL; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INOCULATION; MOUSE; NONHUMAN; PEROXIDASE ANTIPEROXIDASE COMPLEX; PROTEIN ANALYSIS; STAINING; STOMACH ANTRUM; STOMACH EPITHELIUM;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; FEMALE; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; IMMUNOHISTOCHEMISTRY; MICE; MICROSCOPY, ELECTRON;

EID: 33747598047     PISSN: 00015644     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. MARSHALL B.J., WARREN J.R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet, 1984, 1: 1311-1315.
2. HUNT R.H. The role of Helicobacter pylori in pathogenesis: the spectrum of clinical outcomes. Scand. J. Gastroenterol Suppl., 1996, 220: 3-9.
3. BLASER M.J., PARSONNET J. Parasitism by the "slow" bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J. Clin. Invest., 1994, 94: 4-8.
4. CHEN X.G., CORREA P., OFFERHAUS J., RODRIGUEZ E., JANNEY F., HOFFMANN E., FOX J., HUNTER F., DIAVOLITSIS S. Ultrastructure of the gastric mucosa harboring Campylobacter-like organisms. Am. J. Clin. Pathol., 1986, 86: 575-582.
5. BRENES F., RUIZ B., CORREA P., HUNTER F., RHAMAKRISHNAN T., FONTHAM E., SHI T.Y. Helicobacter pylori causes hyperproliferation of the gastric epithelium: pre- and post-eradication indices of proliferating cell nuclear antigen. Am. J. Gastroenterol, 1993, 88: 1870-1875.
6. FRASER A.G., SIM R., SANKEY E.A., DHILLON A.P., POUNDER R.E. Effect of eradication of Helicobacter pylori on gastric epithelial cell proliferation. Aliment Pharmacol. Ther., 1994, 8: 167-173.
7. JONES N.L., SHANNON P.T., CUTZ E., YEGER H., SHERMAN P.M. Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection. Am. J. Pathol., 1997, 151: 1695-1703.
8. MOSS S.F., CALAM J., AGARWAL B., WANG S., HOLT P.R. Induction of gastric epithelial apoptosis by Helicobacter pylori. Gut, 1996, 38: 498-501.
9. HALL P.A., COATES P.J., ANSARI B., HOPWOOD D. Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J. Cell Sci., 1994, 107 (Pt 12): 3569-3577.
10. KERR J.F., WINTERFORD C.M., HARMON B.V. Apoptosis. Its significance in cancer and cancer therapy. Cancer, 1994, 73: 2013-2026.
11. JIANG C., MC CLURE S.F., STODDART R.W., MCCLURE J. Lectin histochemistry of normal human gastric mucosa. Glycoconj J., 2004, 20: 367-374.
12. KERR J.F., WYLLIE A.H., CURRIE A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer, 1972, 26: 239-257.
13. WAGNER S., BEIL W., WESTERMANN J., LOGAN R.P., BOCK C.T., TRAUTWEIN C., BLECK J.S., MANNS M.P. Regulation of gastric epithelial cell growth by Helicobacter pylori: offdence for a major role of apoptosis. Gastroenterology, 1997, 113: 1836-1847.
14. FAN X.J., CHUA A., SHAHI C.N., MC DEVITT J., KEELING P.W., KELLEHER D. Gastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisation. Gut, 1994, 35: 1379-1384.
15. GENTA R.M., LEW G.M., GRAHAM D.Y. Changes in the gastric mucosa following eradication of Helicobacter pylori. Mod. Pathol., 1993, 6: 281-289.
16. UEMURA N., OKAMOTO S., YAMAMOTO S., MATSUMURA N., YAMAGUCHI S., YAMAKIDO M., TANIYAMA K., SASAKI N., SCHLEMPER R.J. Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med., 2001, 345: 784-789.
17. WOTHERSPOON A.C., ORTIZ-HIDALGO C., FALZON M.R., ISAACSON P.G. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet, 1991, 338: 1175-1176.
18. OHKURA Y., FURIHATA T., KAWAMATA H., TABUCHI M., KUBOTA K., TERANO A., SAKAI T., FUJIMORI T. Evaluation of cell proliferation and apoptosis in Helicobacter pylori gastritis using an image analysis processor. Gastric Cancer, 2003, 6: 49-54.
19. SHIRIN H., SORDILLO E.M., OH S.H., YAMAMOTO H., DELOHERY T., WEINSTEIN I.B., MOSS S.F. Helicobacter pylori inhibits the G1 to S transition in AGS gastric epithelial cells. Cancer Res., 1999, 59: 2277-2281.
20. LYNCH D.A., MAPSTONE N.P., CLARKE A.M., SOBALA G.M., JACKSON P., MORRISON L., DIXON M.F., QUIRKE P., AXON A.T. Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy. Gut, 1995, 36: 346-350.
21. COURT M., ROBINSON P.A., DIXON M.F., CRABTREE J.E. Gastric Helicobacter species infection in murine and gerbil models: comparative analysis of effects of H. pylori and H. felis on gastric epithelial cell proliferation. J. Infect. Dis., 2002, 186: 1348-1352.
22. MOSS S.F., SORDILLO E.M., ABDALLA A.M., MAKAROV V., HANZELY Z., PEREZ-PEREZ G.I., BLASER M.J., HOLT P.R. Increased gastric epithelial cell apoptosis associated with colonization with cagA + Helicobacter pylori strains. Cancer Res., 2001, 61: 1406-1411.
23. PEEK R.M., JR., MOSS S.F., THAM K.T., PEREZ-PEREZ G.I., WANG S., MILLER G.G., ATHERTON J.C., HOLT P.R., BLASER M.J. Helicobacter pylori cagA+ strains and dissociation of gastric epithelial cell proliferation from apoptosis. J. Natl. Cancer Inst., 1997, 89: 863-868.
24. SUZUKI H., MIYAZAWA M., NAGAHASHI S., MORI M., SETO K., KAI A., SUZUKI M., MIURA S., ISHII H. Attenuated apoptosis in H. pylori-colonized gastric mucosa of Mongolian gerbils in comparison with mice. Dig. Dis. Sci., 2002, 47: 90-99.
25. HIRAYAMA F., TAKAGI S., YOKOYAMA Y. IWAO E., IKEDA Y. Establishment of gastric Helicobacter pylori infection in Mongolian gerbils. J. Gastroenterol., 1996, 31 Suppl 9: 24-28.
26. MARCHETTI M., ARICO B., BURRONI D., FIGURA N., RAPPUOLI R., GHIARA P. Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science, 1995, 267: 1655-1658.
27. MARCHETTI M., ARICO B., BURRONI D., FIGURA N., RAPPUOLI R., GHIARA P. Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science, 1995, 267: 1655-1658.
28. LEE A., O'ROURKE J., DE UNGRIA M.C., ROBERTSON B., DASKALOPOULOS G., DIXON M.F. A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology, 1997, 112: 1386-1397.
29. CRABTREE J.E., COURT M., ABOSHKIWA M.A., JEREMY A.H., DIXON M.F., ROBINSON P.A. Gastric mucosal cytokine and epithelial cell responses to Helicobacter pylori infection in Mongolian gerbils. J. Pathol., 2004, 202: 197-207.
30. WIRTH H.P., BEINS M.H., YANG M., THAM K.T., BLASER M.J. Experimental infection of Mongolian gerbils with wild-type and mutant Helicobacter pylori strains. Infect. Immun., 1998, 66: 4856-4866.
31. ISRAEL D.A., SALAMA N., ARNOLD C.N., MOSS S.F., ANDO T., WIRTH H.P., THAM K.T., CAMORLINGA M., BLASER M.J., FALKOW S., PEEK R.M., Jr. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. J. Clin. Invest., 2001, 107: 611-620.
32. AKANUMA M., MAEDA S., OGURA K., MITSUNO Y., HIRATA Y., IKENOUE T., OTSUKA M., WATANABE T., YAMAJI Y., YOSHIDA H., KAWABE T., SHIRATORI Y., OMATA M. The evaluation of putative virulence factors of Helicobacter pylori for gastroduodenal disease by use of a short-term Mongolian gerbil infection model. J Infect Dis, 2002, 185: 341-347.
33. RAFF M. Cell suicide for beginners. Nature, 1998, 396: 119-122.
34. KRAMMER P.H. CD95(APO-1/Fas)-mediated apoptosis: live and let die. Adv. Immunol, 1999, 71: 163-210.
35. ADAMS J.M., CORY S. The Bcl-2 protein family: arbiters of cell survival. Science, 1998, 281: 1322-1326.
36. YAGMURDUR M.C., TURK E., MORAY G., CAN F., DEMIRBILEK M., HABERAL N., KARABAY G., KARAKAYALi H., HABERAL M. Effects of heparin on bacterial translocation and gut epithelial apoptosis after burn injury in the rat: dose-dependent inhibition of the complement cascade. Burns, 2005, 31: 603-609.
37. GAVRIELI Y., SHERMAN Y., BEN-SASSON S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 1992, 119: 493-501.
38. PATEL S., REW D.A., TAYLOR I., POTTEN C.S., OWEN C., ROBERTS S.A. Study of the proliferation in human gastric mucosa after in vivo bromodeoxyuridine labelling. Gut, 1993, 34: 893-896.