Expression of tumor-associated differentially expressed gene-14 (TADG-14/KLK8) and its protein hK8 in uterine endometria and endometrial carcinomas

Tumor Biology

Volumn 27, Issue 5, 2006, Pages 274-282

  Jin, Honghua ^a   Nagai, Nobutaka ^a   Shigemasa, Kazushi ^b   Gu, Lijun ^c   Tanimoto, Hirotoshi ^d   Yunokawa, Mayu ^a   Ohama, Koso ^e   Kudo, Yoshiki ^a   O'Brien, Timothy J ^f  

^a HIROSHIMA UNIVERSITY   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION FUKUYAMA MEDICAL CENTER   (Japan)

^c THE UNIVERSITY OF TOKYO   (Japan)

^d HIROSHIMA CITY ASA HOSPITAL   (Japan)

^e HIROSHIMA PREFECTURAL HOSPITAL   (Japan)

^f UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Endometria; Endometrial carcinomas; hK8 protein; TADG 14 KLK8 mRNA

Indexed keywords

BIOLOGICAL MARKER; MESSENGER RNA; NEUROPSIN; SEX HORMONE;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER STAGING; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOMETRIUM CARCINOMA; FEMALE; GENE EXPRESSION REGULATION; HORMONAL REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

EID: 33747506538     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094741     Document Type: Article

References (40)

1. Liotta LA, Steeg PS, Stetler-Stevenson WG: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 1991;64:327-336.
2. Duffy MJ: The role of proteolytic enzymes in cancer invasion and metastasis. Clin Exp Metastasis 1992;10:145-155.
3. Tanimoto H, Yan Y, Clarke J, Korourian S, Shigemasa K, Parmley TH, Parham GP, O'Brien TJ: Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer. Cancer Res 1997;57:2884-2887.
4. Shigemasa K, Underwood LJ, Beard J, Tanimoto H, Ohama K, Parmley TH, O'Brien TJ: Overexpression of testisin, a serine protease expressed by testicular germ cells, in epithelial ovarian tumor cells. J Soc Gynecol Invest 2000;7:358-362.
5. Tanimoto H, Underwood LJ, Shigemasa K, Parmley TH, O'Brien TJ: Increased expression of protease M in ovarian tumors. Tumor Biol 2001;22:11-18.
6. Tanimoto H, Underwood LJ, Shigemasa K, Yan Yan MS, Clarke J, Parmley TH, O'Brien TJ: The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells. Cancer 1999;86:2074-2082.
7. Underwood LJ, Shigemasa K, Tanimoto H, Beard JB, Schneider EN, Wang Y, Parmley TH, O'Brien TJ: Ovarian tumor cells express a novel multi-domain cell surface serine protease. Biochim Biophys Acta 2000;1502:337-350.
8. Tanimoto H, Underwood LJ, Wang Y, Shigemasa K, Parmley TH, O'Brien TJ: Ovarian tumor cells express a transmembrane serine protease: a potential candidate for early diagnosis and therapeutic intervention. Tumor Biol 2001;22:104-114.
9. Underwood LJ, Tanimoto H, Wang Y, Shigemasa K, Parmley TH, O'Brien TJ: Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma. Cancer Res 1999;59:4435-4439.
10. Yoshida S, Taniguchi M, Hirata A, Shiosaka S: Sequence analysis and expression of human neuropsin cDNA and gene. Gene 1998;213:9-16.
11. Yoshida S, Shiosaka S: Plasticity-related serine proteases in the brain. Int J Mol Med 1999;3:405-409.
12. Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A, Shiosaka S: Ontogeny of neuropsin mRNA expression in the mouse brain. Neurosci Res 1995;23:345-351.
13. Shigemasa K, Tian X, Gu L, Tanimoto H, Underwood LJ, O'Brien TJ, Ohama K: Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer. Oncol Rep 2004;11:1153-1159.
14. Diamandis EP, Yousef GM, Clements J, Ashworth LK, Yoshida S, Egelrud T, Nelson PS, Shiosaka S, Little S, Lilja H, Stenman UH, Rittenhouse HG, Wain H: New nomenclature for the human tissue kallikrein gene family. Clin Chem 2000;46:1855-1858.
15. Rittenhouse HG, Finlay JA, Mikolajczyk SD and parting AW: Human kallikrein 2 (hK2) and prostate-specific antigen (PSA): two closely related, but distinct, kallikreins in the prostate. Crit Rev Clin Lab Sci 1998;35:275-368.
16. Yousef GM, Diamandis EP: The new human tissue kallikrein gene family: structure, function, and association to disease. Endocr Rev 2001;22:184-204.
17. Diamandis EP, Yousef GM: Human tissue kallikreins: a family of new cancer biomarkers. Clin Chem 2002;48:1198-1205.
18. Borgono CA, Michael IP, Eleftherios P, Diamandis EP: Human tissue kallikreins: Physiological roles and applications in cancer. Mol Cancer Res 2004;2:257-280.
19. Kishi T, Grass L, Soosaipillai A, Shimizu-Okabe C, Diamandis EP: Human kallikrein 8:immunoassay development and identification in tissue extracts and biological fluids. Clin Chem 2003;49:87-96.
20. Benedet JL, Bender H, Jones H 3rd, Ngan HY, Pecorelli S: FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynecol Obstet 2000;70:209-262.
21. Scully RE, Bonfiglio TA, Kurman RJ, Silverberg SG, Wilkinson EJ: Histological Typing of Female Genital Tract Tumours, ed 2. Berlin, Springer, 1994, pp 13-18.
22. Shigemasa K, Hu C, West CM, Moon SH, Parham GP, Parmley TH, Korourian S, Baker VV, O'Brien TJ: p21:a monitor of p53 dysfunction in ovarian neoplasia. Int J Gynecol Cancer 1997;7:296-303.
23. Kuwae K, Matsumoto-Miyai K, Yoshida S, Sadayama T, Yoshikawa K, Hosokawa K, Shiosaka S: Epidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samples. Mol Pathol 2002;55:235-241.
24. Yousef GM, Yacoub GM, Polymeris ME, Popalis C, Soosaipillai A, Diamandis EP: Kallikrein gene downregulation in breast cancer. Br J Cancer 2004;90:167-172.
25. Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA: Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. J Biol Chem 2000;275:37397-37406.
26. Magklara A, Scorilas A, Katsaros D, Massobrio M, Yousef GM, Fracchioli S, Danese S, Diamandis EP: The human KLK8 (Neuropsin/ Ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. Clin Cancer Res 2001;7:806-811.
27. Kishi T, Grass L, Soosaipillai A, Scorilas A, Harbeck N, Schmalfeldt B, Dorn J, Mysliwiec M, Schmitt M, Diamandis EP: Human kallikrein 8, a novel biomarker for ovarian carcinoma. Cancer Res 2003;63:2771-2774.
28. Cane S, Bignotti E, Bellone S, Palmieri M, De las Casas L, Roman JJ, Pecorelli S, Cannon MJ, O'Brien T, Santin AD: The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/neuropsin/ovasin) is highly overexpressed in cervical cancer. Am J Obstet Gynecol 2004;190:60-66.
29. Magklara A, Grass L, Diamandis EP: Differential steroid hormone regulation of human glandular kallikrein (hK2) and prostate-specific antigen (PSA) in breast cancer cell lines. Breast Cancer Res Treat 2000;59:263-270.
30. Fuller PJ, Matheson BA, MacDonald RJ, Verity K, Clements JA: Kallikrein gene expression in estrogen-induced pituitary tumors. Mol Cell Endocrinol 1988;60:225-232.
31. Clements J, Mukhtar A, Ehrlich A, Yap B: Glandular kallikrein gene expression in the human uterus. Braz J Med Biol Res 1994;27:1855-1863.
32. Clements J, Mukhtar A: Glandular kallikreins and prostate-specific antigen are expressed in the human endometrium. J Clin Endocrinol Metab 1994;78:1536-1539.
33. Petraki CD, Karavana VN, Skoufogiannis PT, Little SP, Howarth DJ, Yousef GM, Diamandis EP: The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry. J Histochem Cytochem 2001;49:1431-1441.
34. Xi Z, Kærn J, Davidson B, Klokk TI, Risberg B, Trope C, Saatcioglu F: Kallikrein 4 is associated with paclitaxel resistance in ovarian cancer. Gynecol Oncol 2004;94:80-85.
35. Obiezu CV, Scorilas A, Katsaros D, Massobrio M, Yousef GM., Fracchioli S, Rigault de la Longrais IA, Arisio R, Diamandis EP: Higher human kallikrein gene 4 (KLK4) expression indicates poor prognosis of ovarian cancer patients. Clin Cancer Res 2001;7:2380-2386.
36. Myers SA, Clements JA: Kallikrein 4 (KLK4), a new member of the human kallikrein gene family is up-regulated by estrigen and progesterone in the human endometrial cancer cell line, KLE. J Clin Endocrinol Metab 2001;86:2323-2326.
37. Clements J, Mukhtar A: Tissue kallikrein and the bradykinin B2 receptor are expressed in endometrial and prostate cancers. Immunopharmacology 1997;36:217-220.
38. Yousef GM, Borgono CA, White NM, Robb JD, Michael IP, Oikonomopoulou K, Khan S, Diamandis EP: In silico analysis of the human kallikrein gene 6. Tumour Biol 2004;25:282-289.
39. Ghosh MC, Grass L, Soosaipillai A, Sotiropoulou G, Diamandis EP: Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells. Tumour Biol 2004;25:193-199.
40. Yousef GM, Diamandis EP: Expanded human tissue kallikrein family: a novel panel of cancer biomarkers. Tumour Biol 2002;23:185-192.