The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer

American Journal of Obstetrics and Gynecology

Volumn 190, Issue 1, 2004, Pages 60-66

  Cane', Stefania ^a   Bignotti, Eliana ^c   Bellone, Stefania ^a   Palmieri, Michela ^c   De Las Casas, Luis ^b   Roman, Juan J ^a   Pecorelli, Sergio ^c   Cannon, Martin J ^b   O'Brien, Timothy ^a   Santin, Alessandro D ^a,d  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIVERSITY OF BRESCIA   (Italy)

^d UNIVERSITY OF ARKANSAS MEDICAL CENTER   (United States)

Author keywords

Cervical cancer; Serine protease; Tumor associated differentially expressed gene 14

Indexed keywords

NEUROPSIN; SERINE PROTEINASE;

ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; EVALUATION; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERINE CERVIX CARCINOMA; UTERINE CERVIX EPITHELIUM; VALIDATION PROCESS;

EID: 10744225521     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2003.07.020     Document Type: Article

References (26)

1. Tryggvason K, Hoyhtya M, Salo T. Proteolytic degradation of extracellular matrix in tumor invasion. Biochem Byophys Acta 1987;907:191-207.
2. Liotta LA, Steeg PS, Stetler-Stevenson WG. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 1991;64:327-36.
3. Duffy MJ. The role of proteolytic enzymes in cancer invasion and metastasis. Clin Exp Metastasis 1992;10:145-55.
4. Hooper JD, Clements JA, Quigley JP, Antalis TM. Type II transmembrane serine proteases: insights into an emerging class of cell surface proteolytic enzymes. J Biol Chem 2001;276:857-60.
5. Brand K. Cancer gene therapy with tissue inhibitors of metalloproteinases (TIMPs). Curr Gene Ther 2002;2:255-71.
6. Leytus SP, Loeb KR, Hagen FS, Kurachi K, Davie EW. A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells. Biochem 1988;27:1067-74.
7. Underwood LJ, Shigemasa K, Tanimoto H, Beard JB, Schneider EN, Wang Y, et al. Ovarian tumor cells express a novel multidomain cell surface serine protease. Biochim Biophys Acta 2000; 1502:337-50.
8. Underwood LJ, Tanimoto H, Wang Y, Shigemasa K, Parmley TH, O'Brien TJ. Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma. Cancer Res 1999;59:4435-9.
9. Tanimoto H, Underwood LJ, Wang Y, Shigemasa K, Parmley TH, O'Brien TJ. Ovarian tumor cells express a transmembrane serine protease: a potential candidate for early diagnosis and therapeutic intervention. Tumour Biol 2001;22:104-14.
10. Hooper JD, Nicol DL, Dickinson JL, Eyre HJ, Scarman AL, Normyle JF, et al. Testisin, a new human serine protease expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors. Cancer Res 1999;59:3199-205.
11. Hansson L, Strömqvist M, Bäckman A, Wallbrandt P, Carlstein A, Egelrud T. Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. J Biol Chem 1994;269:19420-6.
12. Goldstein LA, Ghersi G, Pineiro-Sanchez ML, Salamone M, Yeh Y, Flessate D, et al. Molecular cloning of seprase: a serine integral membrane protease from human melanoma. Biochim Biophys Acta 1997;1361:11-9.
13. Tanimoto H, Underwood LJ, Shigemasa K, Parmley TH, O'Brien TJ. Increased expression of protease M in ovarian tumors. Tumour Biol 2001;22:11-8.
14. McCormack RT, Rittenhouse HG, Finlay JA, Sokoloff RL, Wang TJ, Wolfert RL, et al. Molecular forms of prostate-specific antigen and the human kallikrein gene family: a new era. Urology 1995;45: 729-44.
15. Duffy MJ, Maguire TM, McDermott EW, O'Higgins N. Urokinase plasminogen activator: a prognostic marker in multiple types of cancer. J Surg Oncol 1999;71:130-5.
16. +) lymphocytes by E7-pulsed autologous dendritic cells in patients with human papillomavirus type 16-and 18-positive cervical cancer. J Virol 1999;73:5402-10.
17. Ueda M, Fujii H, Yoshizawa K, Terai Y, Kumagai K, Ueki K, et al. Effects of EGF and TGF-alpha on invasion and proteinase expression of uterine cervical adenocarcinoma OMC-4 cells. Invasion Metastasis 1998;18:176-83.
18. Asha Nair S, Karunagaran D, Nair MB, Sudhakaran PR. Changes in matrix metalloproteinases and their endogenous inhibitors during tumor progression in the uterine cervix. J Cancer Res Clin Oncol 2003;129:123-31.
19. Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A, et al. Ontogeny of neuropsin mRNA expression in the mouse brain. Neurosci Res 1995;23:345-51.
20. Shimizu C, Yoshida S, Shibata M, Kato K, Momota Y, Matsumoto K, et al. Characterization of recombinant and brain neuropsin, a plasticity-related serine protease. J Biol Chem 1998;273:11189-96.
21. DiSaia PJ, Creasman WT. Clinical gynecologic oncology: invasive cervical cancer. 5th ed. St Louis: Mosby; 1997. p. 51-106.
22. Magklara A, Scorilas A, Katsaros D, Massobrio M, Yousef GM, Fracchioli S, et al. The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. Clin Cancer Res 2001;7:806-11.
23. Steinman RM, Pope M. Exploiting dendritic cells to improve vaccine efficacy. J Clin Invest 2002;109:1519-26.
24. Cannon MJ, O'Brien TJ, Underwood LJ, Crew MD, Bondurant KL, Santin AD. Novel target antigens for dendritic cell-based immunotherapy against ovarian cancer. Exp Rev Anticancer Ther 2002;2:97-105.
25. Heiser A, Coleman D, Dannull J, Yancey D, Maurice MA, Lallas CD, et al. Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors. J Clin Invest 2002;109:409-17.
26. Nouri-Shirazi M, Banchereau J, Bell D, Burkeholder S, Kraus ET, Davoust J. et al. Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses. J Immunol 2000;165:3797-803.