Synthesis, calpain inhibitory activity, and cytotoxicity of P 2-substituted proline and thiaproline peptidyl aldehydes and peptidyl α-ketoamides

Journal of Medicinal Chemistry

Volumn 49, Issue 17, 2006, Pages 5282-5290

  Korukonda, Rajani ^a   Guan, Na ^b   Dalton, James T ^b   Liu, Jiuyu ^a   Donkor, Isaac O ^a,c  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c Johnson Bldg ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 IODOPHENYLSULFONYL) N (1 OXO 3 PHENYLPROPAN 2 YL)PYRROLIDINE 2 CARBOXAMIDE; 1 (4 NITROPHENYLSULFONYL) N (1 OXO 3 PHENYLPROPAN 2 YL)PYRROLIDINE 2 CARBOXAMIDE; ANTINEOPLASTIC AGENT; CALPAIN; CYSTEINE PROTEINASE; PEPTIDE; PEPTIDYL ALDEHYDE DERIVATIVE; PEPTIDYL ALPHA KETOAMIDE DERIVATIVE; PROLINE; THIAPROLINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DAUDI CELL; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE;

ALDEHYDES; CALPAIN; CATHEPSIN B; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; PROLINE; PYRROLIDINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; THIAZOLES; THIAZOLIDINES;

EID: 33747482063     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050849w     Document Type: Article

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