Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis

Clinical and Experimental Immunology

Volumn 126, Issue 1, 2001, Pages 143-150

  Steiner, K ^a   Moosig, F ^b   Csernok, E ^b   Selleng, K ^c   Gross, W L ^b   Fleischer, B ^a   Bröker, Barbara M ^a,c  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

B lymphocytes; CTLA 4 (CD152); T lymphocytes; Wegener's granulomatosis

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; CYCLOPHOSPHAMIDE; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; METHOTREXATE; PREDNISOLONE;

ACUTE DISEASE; ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; FEMALE; GRANULOMATOUS INFLAMMATION; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNE SYSTEM; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; STIMULATION; T LYMPHOCYTE; TH1 CELL; TH2 CELL; WEGENER GRANULOMATOSIS;

ADULT; AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; B-LYMPHOCYTES; CELLS, CULTURED; FEMALE; HUMANS; IMMUNOCONJUGATES; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MITOGENS; T-LYMPHOCYTES; WEGENER GRANULOMATOSIS;

EID: 0034781896     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01575.x     Document Type: Article

References (44)

1. CTLA-4 and CD28 mRNAs are coexpressed in most activated T cells after activation: Expression of CTLA-4 and CD28 messenger RNA does not correlate with the pattern of lymphokine production
2. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes
3. CTLA-4 can function as a negative regulator of T cell activation
4. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
5. The yin and yang of T-cell costimulation
6. Distinct roles for CD28 and cytotoxic T lymphocyte associated molecule-4 during T-cell activation?
7. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
8. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
9. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent of CD28 costimulation and inhibited by CTLA-4
10. Enhancement of antitumor immunity by CTLA-4 blockade
11. Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer
12. Protective immunity to nematode infection is induced by CTLA-4 blockade
13. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis
14. CTLA-4 in autoimmune diseases - A general susceptibility gene to autoimmunity?
15. ANCA an associated diseases: Immunodiagnostic and pathogenic aspects
16. Wegener's granulomatosis: Anti-proteinase 3 antibodies are potents inductors of human endothelial cell signaling and leakage response
17. Activated CD4+ and CD8+ T cell subsets in Wegener's granulomatosis
18. Elevated serum levels of soluble interleukine-2 receptor in patients with Wegener's granulomatosis
19. Active Wegener's granulomatosis is associated with HLA-DR+CD4+ T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: Reversal with IL-10
20. Cytokine profiles in Wegener's granulomatosis: Predominance of type 1 (Th1) in the granulomatous inflammation
21. Costimulatory molecules in Wegener's granulomatosis (WG): Lack of expression of CD28 and preferential upregulation of its ligands B7/1 (CD80) and B7/2 (CD86)
22. Accumulation of CTLA-4 expressing T lymphocytes in the germinal centres of human lymphoid tissues
23. The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis
24. Nomenclature of systemic vasculitis. Proposal of an international consensus conference
25. Influence of disease manifestations and anti-neutrophil cytoplasmic antibody titer on the response to pulse cyclophosphamide therapy in patients with Wegener's granulomatosis
26. Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection
27. High plasma levels of soluble form of CD30 activation molecule reflect disease activity in patients with Wegener's granulomatosis
28. Expression of functional B7 and CTLA-4 on rheumatoid synovial T cells
29. Immunological abnormalities in human immunodeficiency virus (HIV) -infected asymptomatic homosexual men. HIV affects the immune system before CD4+ helper T cell depletion occurs
30. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging
31. Selective loss of T cell functions in different stages of HIV infection
32. Superantigen activation of CD4+ and CD8+ T cells from HIV-infected subjects: Role of costimulatory molecules and antigen-presenting cells (APC)
33. Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8+ T cells from HIV-infected subjects
34. Expression of CTLA-4 molecule in peripheral blood T lymphocytes from patients with systemic lupus erythematosus
35. The role of CTLA-4 in regulating Th2 differentiation
36. Induction of T cell tolerance in vivo requires CTLA-4 engagement
37. Is CTLA-4 a master switch for peripheral T cell tolerance?
38. Transient expression of CTLA-4 on medullary thymocytes
39. CD41 αβ-T lymphocytes express high levels of the T lymphocyte antigen CTLA-4 (CD152) in acute malaria
40. Activated T cells can induce high levels of CTLA-4 expression on B cells
41. Inhibition of IgG1 and IgE Production by stimulation of the B cell CTLA-4 receptor
42. Activation of lymphocytes by BAT and anti-CTLA-4: Comparison of binding to T and B cells