N-hexacosanol reverses diabetic induced muscarinic hypercontractility of ileum in the rat

European Journal of Pharmacology

Volumn 545, Issue 2-3, 2006, Pages 177-184

  Shinbori, Chiko ^a   Saito, Motoaki ^a   Kinoshita, Yukako ^a   Satoh, Itaru ^a   Kono, Tomoharu ^a   Hanada, Takuya ^a   Nanba, Eiji ^b   Adachi, Kaori ^b   Suzuki, Hiroto ^c   Yamada, Masashi ^c   Satoh, Keisuke ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c MEIJI DAIRIES CORPORATION   (Japan)

Author keywords

Cyclohexenonic long chain fatty alcohol; Diabetes; mRNA; Muscarinic M2 receptor; Muscarinic M3 receptor; Neuropathy

Indexed keywords

GLUCOSE; HEXACOSANOL; INSULIN; MESSENGER RNA; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; ILEUM CONTRACTION; INSULIN BLOOD LEVEL; INTESTINAL DYSMOTILITY; INTESTINE WALL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES;

ANIMALS; CALCIUM; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; FATTY ALCOHOLS; ILEUM; MALE; MUSCLE CONTRACTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; STREPTOZOCIN;

EID: 33747372773     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.06.043     Document Type: Article

References (37)

1. Anitha M., Gondha C., Sutliff R., Parsadanian A., Mwangi S., Sitaraman S.V., and Srinivasan S. GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of PI3K/Akt pathway. J. Clin. Invest. 116 (2006) 344-356
2. Anjaneyulu M., and Ramarao P. Studies on gastrointestinal tract functional changes in diabetic animals. Methods Find. Exp. Clin. Pharmacol. 24 (2002) 71-75
3. Borg J., Toazara J., Heitter H., Henry M., Schmitt G., and Luu B. Neurotrophic effect of naturally occurring long-chain fatty alcohols on cultured CNS neurons. FEBS Lett. 213 (1987) 406-410
4. Brog J., Kesslak P.J., and Cotman C.W. Peripheral administration of a long-chain fatty alcohol promotes septal cholinergic neurons survival after fimbria-fornix transection. Brain Res. 518 (1990) 295-298
5. Buckley N.J., and Caulfield M.P. Transmission: acetylcholine. In: Burnstock G., and Hoyle C.H.V. (Eds). Autonomic Neuroeffector Mechanisms (1992), Harwood Academic Publishers, USA 265-322
6. Candell L.M., Yun S.H., Tran L.L.P., and Ehlert F.J. Differential coupling of subtypes of the muscarinic receptor to adenylyl cyclase and phosphoinositide hydrolysis in the longitudinal muscle of the rat ileum. Mol. Pharmacol. 38 (1990) 689-697
7. Carrier G.O., and Aronstam R.S. Increased muscarinic responsiveness and decreased muscarinic receptor content in ileal smooth muscle in diabetes. J. Pharmacol. Exp. Ther. 254 (1990) 445-449
8. 2 muscarinic receptors in trachea and ileum of diabetic rats. Br. J. Pharmacol. 135 (2002) 1355-1362
9. Damge C., Hillaere-Buys D., Koeng M., Gross R., Hoeltzel A., Chapal J., Balboni G., Borg J., and Ribes G. Effect of n-hexacosanol on insulin secretion in the rat. Eur. J. Pharmacol. 274 (1995) 133-139
10. Eglen R.M., Reddy H., Watson N., and Challis R.A.J. Muscarinic receptor subtypes in smooth muscle. Trends Pharmacol. Sci. 15 (1994) 114-117
11. Eglen R.M., Hegde R.S., and Watson N. Muscarinic receptor subtypes and smooth muscle function. Pharmacol. Rev. 48 (1996) 531-565
12. Ehlert F.J. Contractile role of M2 and M3 muscarinic receptors in gastrointestinal, airway and urinary bladder smooth muscle. Life Sci. 74 (2003) 355-366
13. Fraser C.M., and Lee N.H. Regulation of muscarinic receptor expression by changes in mRNA stability. Life Sci. 56 (1995) 899-906
14. Hosking D.J., Bennet T., and Hampton J.R. Diabetic autonomic neuropathy. Diabetes 27 (1978) 1043-1054
15. Jover E., Gonzalez de Aguilar J.L., Luu B., and Lutz-Bucher B. Effect of a cyclohexenonic long-chain fatty alcohol on calcium mobilization. Eur. J. Pharmacol. 516 (2005) 197-203
16. Kinoshita Y., Saito M., Satoh I., Shomori K., Suzuki H., Yamada M., Kono T., and Satoh K. General administration of cyclohexenonic long-chain fatty alcohol ameliorates hyperreactivity of STZ-induced diabetic rat aorta. Life Sci. 78 (2006) 1508-1514
17. Korolkiewicz R., Rekowski P., Szyk A., Kato S., Yasuhiro T., Kubomi M., Tashima K., and Takeuchi K. Effects of diabetes mellitus on the contractile activity of carbachol and galanin in isolated gastric fundus strips of rats. Pharmacology 57 (1998) 65-78
18. Latifpour J., Gousse A., Kondo S., Morita T., and Weiss R.M. Effects of experimental diabetes on biochemical and functional characteristics of bladder muscarinic receptors. J. Pharmacol. Exp. Ther. 248 (1989) 81-89
19. Lazareno S., and Roberts F.F. Functional and binding studies with muscarinic M2-subtype selective antagonists. Br. J. Pharmacol. 98 (1989) 309-317
20. Lucas P.D., and Sardar A.M. Effects of diabetes on cholinergic transmission in two rat gut preparations. Gastroenterology 100 (1991) 123-128
21. Luu B., de Aguilar J.L.G., and Junges C.G. Cyclohexenonic long-chain fatty alcohols as neuronal growth stimulators. Molecules 5 (2000) 1439-1460
22. Mansfield K.J., Liu L., Mitchelson F.J., Moore K.H., Millard R.J., and Burcher E. Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT-PCR: changes in ageing. Br. J. Pharmacol. 144 (2005) 1089
23. Michel A.D., and Whiting R.L. Direct binding studies on ileal and cardiac muscarinic receptors. Br. J. Pharmacol. 92 (1987) 755-767
24. Ozturk Y., Altan V.M., and Yildizoglu-Ari N. Effects of experimental diabetes and insulin on smooth muscle functions. Pharmacol. Rev. 48 (1996) 69-112
25. Saito M., Suzuki H., Yamada M., and Miyagawa I. Preventive effect of long-chain fatty alcohol on ischemia-reperfusion injury in the rat bladder. Eur. J. Pharmacol. 454 (2002) 81-84
26. Saito M., Suzuki H., Yamada M., Hikita K., Kobayashi N., Kinoshita Y., Houri D., Miyagawa I., and Satoh K. Effect of cyclohexenonic long-chain fatty alcohol on rat overactive bladder induced by bladder neck obstruction. Eur. J. Pharmacol. 501 (2004) 143-149
27. Saito M., Tominaga L., Nanba E., and Miyagawa I. Expression of heat shock protein 70 and its mRNAs during ischemia-reperfusion in the rat prostate. Eur. J. Pharmacol. 487 (2004) 199-203
28. Samson M., and Smont A.J. Abnormal gastric and small intestinal motor function in diabetes mellitus. Dig. Dis. 15 (1997) 263-274
29. Satoh I., Saito M., Kinoshita Y., Shomori K., Suzuki H., Yamada M., Kono T., and Satoh K. Effects of cyclohexenonic long-chain fatty alcohol on diabetic rat trachea. Life Sci. 77 (2005) 2030-2039
30. Schwab Y., Moton J., Chasserot-Golaz S., Marty I., Maulet Y., and Jover E. Calcium-dependent translocation of synaptotagmin to the plasma membrane in the dendrites of developing neurons. Brain Res. Mol. Brain Res. 96 (2001) 1-13
31. Suzuki H., Saito M., Kinoshita Y., Satoh I., Kono T., Shinbori C., Anastasios S., Yamada M., and Satoh K. Preventive effect of cyclohexenonic long-chain fatty alcohol on diabetic neuropathy in the rat bladder. Can. J. Physiol. Pharmacol. 84 (2006) 195-201
32. Thomas P.K., and Eliasson S.G. Diabetic neuropathy. In: Duck P.J., Thomas P.K., and Lambert E.H. (Eds). Peripheral Neuropathy (1975), WB. Saunders, Philadelphia
33. Watanabe T., and Miyagawa I. Effect of long-chain fatty alcohol on peripheral nerve conduction and bladder function in diabetic rats. Life Sci. 70 (2002) 2215-2224
34. Wittwer C.T., Ririe K.M., Andrew R.V., David D.A., Gundry R.A., and Bali U.J. The LightCycler: a microvolume multisample fluorometer with rapid temperature control. Biol. Tech. 22 (1997) 176-181
35. Yang C.M. Muscarinic receptor expression in the primary culture of tracheal smooth muscle cells. J. Recept. Res. 10 (1990) 235-247
36. Zhang L.B., and Buxton I.L.O. Muacarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways. Mol. Pharmacol. 40 (1991) 952-959
37. Zhang L.B., Horowitz B., and Buxton I.L.O. Muacarinic receptors in canine colonic circular smooth muscle. I. Coexistence of M2 and M3 subtypes. Mol. Pharmacol. 40 (1991) 943-951